S100a8、S100a9在支气管哮喘发生机制中的研究进展  

Research progress of S100a8 and S100a9 in pathogenesis of bronchial asthma

作　　者：袁小慧 陈莉延[1,2] YUAN Xiaohui;CHEN Liyan(State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China;Shenzhen Hezheng Hospital,Shenzhen 518073,China)

机构地区：[1]广州医科大学附属第一医院广州呼吸健康研究院,呼吸疾病国家重点实验室,国家呼吸疾病临床医学研究中心,广州510120 [2]深圳禾正医院,深圳518073

出　　处：《中国免疫学杂志》2025年第3期704-708,共5页Chinese Journal of Immunology

基　　金：重大慢性非传染性疾病防控研究重点专项(2018YFC1311403);国家自然科学基金面上项目(81470221);广东省自然科学基金(2017A030313811);广东省教育厅研究生教育创新计划项目(2017JGXM-MS48);呼吸疾病国家重点实验室自主课题(青年项目)(SKLRD-QN-201701)。

摘　　要：S100a8和S100a9蛋白是S100蛋白家族的重要成员,可通过激活细胞内信号级联反应诱导炎症产生,同时其强大的钙离子结合能力使其在调控细胞收缩方面发挥重要作用。S100a8和S100a9不仅参与调节哮喘气道炎症,而且对哮喘气道高反应也具有保护作用。本文拟对S100a8、S100a9蛋白在哮喘气道炎症和气道高反应中的作用进行综述,为哮喘研究及防治提供新思路。S100a8 and S100a9 protein are important members of the S100 protein family.It can induce inflammation by activating intracellular signal cascade,and its strong calcium binding ability makes it play an important role in regulating cell contraction.It has been reported that S100a8 and S100a9 could not only regulate asthmatic airway inflammation,but also have a protective effect on asthmatic airway hyperresponsiveness.This article intends to review the role of S100a8 and S100a9 proteins in airway inflammation and airway hyperresponsiveness in asthma,so as to provide new ideas for the research and prevention of asthma.

关 键 词：S100A8 S100A9 哮喘 AHR 

分 类 号：R563.9[医药卫生—呼吸系统]