LYSOSOMAL

作品数：147被引量：318H指数：10
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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo
《Neural Regeneration Research》2025年第9期2633-2644,共12页Zhimin Long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He 
supported by the National Natural Science Foundation of China,No.82201582(to QT);Scientific and Technological Research Program of Chongqing Municipal Education Commission,No.KJQN202200457(to QT);General Project of Changqing Natural Science Foundation,No.cstc2021jcyjmsxmX0442(to ZL);CQMU Program for Youth Innovation in Future Medicine,No.W0044(to ZD and GH);Direct Research Project for PhD of Chongqing,No.CSTB2022BSXM-JCX0051(to ZL);the Project of the Top-Notch Talent Cultivation Program For the Graduate Students of Chongqing Medical University,No.BJRC202310(to CG)。
Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque formation.Therefore,resto ring normal lysosomal funct...
关键词：Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPASE 
Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease
《Neural Regeneration Research》2025年第2期424-439,共16页Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin 
supported by the Natural Science Foundation of Shanghai,No.22ZR147750;Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission,No.23Y11906600;Shanghai Changzheng Hospital Innovative Clinical Research Project,No.2020YLCYJ-Y02(all to YY).
Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within...
关键词：Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases 
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
《Cell Research》2024年第12期822-823,共2页Benoit Viollet Bruno Guigas 
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability,proliferation,and function.Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMP...
关键词：METABOLISM function. LYSOSOMAL 
Thio-ProTide strategy:A novel H_(2)S donor-drug conjugate(DDC)alleviates hepatic injury via innate lysosomal targeting
《Acta Pharmaceutica Sinica B》2024年第12期5341-5356,共16页Haowen Jin Jie Ma Bixin Xu Sitao Xu Tianyu Hu Xin Jin Jiankun Wang Guangji Wang Le Zhen 
supported by the National Natural Science Foundation of China(grant No.82173686);CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-5-011,China);Leading Technology Foundation Research Project of Jiangsu Province(BK20192005,China);Outstanding Youth Foundation of Jiangsu Province(No.BK20200081,China).
Hydrogen sulfide(H_(2)S)is a gas signaling molecule with versatile bioactivities;however,its exploitation for disease treatment appears challenging.This study describes the design and characteriza-tion of a novel type...
关键词：ProTide prodrug Hydrogen sulfide donor Drug conjugate Cellular pharmacokinetics Liver fibrosis Lipid peroxidation Lysosomal targeting Prodrug activation 
A lysosomal-targeted Pt(Ⅱ) metallacycle for NIR-Ⅱ fluorescence imaging guided highly efficient tumor immunogenic cell death
《Science China Chemistry》2024年第11期3508-3509,共2页Qihang Ding Shuai Zhang Jong Seung Kim 
Cisplatin, carboplatin, and oxaliplatin are well-known firstline antineoplastic drugs that have been approved worldwide. Recently, the successful integration of chemotherapy and immunotherapy in clinical trials has hi...
关键词：drugs chemotherapy CISPLATIN DEATH 
Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders
《Chinese Chemical Letters》2024年第11期454-460,共7页Jiao Chen Zihan Zhang Guojin Sun Yudi Cheng Aihua Wu Zefan Wang Wenwen Jiang Fulin Chen Xiuying Xie Jianli Li 
supported by the National Natural Science Foundation of China(Nos.22077099,22171223 and 22307102);the Innovation Capability Support Program of Shaanxi(Nos.2023-CXTD-75 and 2022KJXX-32);the Technology Innovation Leading Program of Shaanxi(Nos.2023KXJ-209 and 2024QCY-KXJ-142);the Key Research and Development Program of Shaanxi(No.2024GHZDXM-22);the Natural Science Basic Research Program of Shaanxi(Nos.2023-JC-YB-141 and 2022JQ-151);Young Talent Fund of Association for Science and Technology in Shaanxi,China(No.SWYY202206);the Shaanxi Fundamental Science Research Project for Chemistry&Biology(Nos.22JHZ010 and 22JHQ080);the Yan’an City Science and Technology Project(No.2022SLZDCY-002)。
Benzo[4,5]imidazo[1,2-a]pyrimidine-based derivatives play crucial roles in medicines,pesticides,tracers and photoelectric materials.However,their synthesis approach still needs to be optimized,and their fluorescent pr...
关键词：Fluorescent sensor Benzo[4 5]imidazo[1 2-a]pyrimidine Lysosome VISCOSITY Lysosomal storage disorders Structure-inherent targeting Fluorescence imaging 
Isoform-and cell-state-specific APOE homeostasis and function被引量：2
《Neural Regeneration Research》2024年第11期2456-2466,共11页Karina Lindner Anne-Claude Gavin 
supported by the financial support of the Louis-Jeantet Foundation(to ACG).
Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling.It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing...
关键词：Alzheimer’s disease apolipoprotein E autophagy CHOLESTEROL lipid detoxification lipid transport lysosomal failure metabolic impairment TRIACYLGLYCEROL 
Targeted imaging of lysosomal zinc ions with a tetrahedral DNA framework fluorescent reporter
《National Science Review》2024年第11期154-165,共12页Yue Gao Xia Liu Wei Li Yuncong Chen Shitai Zhu Qinglong Yan Shanshan Geng Jichao Zhang Yong Guan Qian Li Sisi Jia Lihua Wang Jiang Li Weijiang He Chunhai Fan Zijian Guo Ying Zhu 
supported by the National Key R&D Program of China(2023YFC3404200 to Y.Z.);the National Natural Science Foundation of China(T2188102 and 21991134 to C.F.,22325406 to J.L.,and 12305400 to Q.Y.);the New Cornerstone Investi-gator Program(to C.F.),the 2022 Shanghai‘Science and Tech-nology Innovation Action Plan’Fundamental Research Project(22JC1401203 to Y.Z.);the Xiangfu Lab Research Project(XF012022E0100 to C.F.).
Abnormal levels of zinc ions within endo-lysosomes have been implicated in the progression of Alzheimer’s disease(AD),yet the detection of low-concentration zinc ions at the organelle level remains challenging.Here w...
关键词：DNA framework(DNF) TETRAHEDRON LYSOSOME zinc ions Alzheimer’s disease 
A novel target to turn cold tumors into hot tumors: lysosomal 25-hydroxycholesterol activates AMPKα and immunosuppressive tumor-associated macrophages
《Cellular & Molecular Immunology》2024年第8期801-803,共3页Shuangshuang Liu Jiaqi Wu Xiao Tong Li-Hao Huang 
National Natural Science Foundation of China(Project:32371243,32171168,32350610248).
In a recent issue of Immunity,Xiao et al.reported that cholesterol 25-hydroxylase(CH25H)is a novel immunometabolic checkpoint and a potential drug target for tumor immunotherapy[1].Their study elucidated how CH25H inf...
关键词：CHOLESTEROL al. cancer 
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
《Bone Research》2024年第2期407-420,共14页Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee 
supported by grants from the National Research Foundation of Korea(RS-2023-00217798 and 2021R1A2C3003675 to S.Y.L.);by the Korea Basic Science Institute National Research Facilities&Equipment Center grant(2019R1A6C1010020).M.K.was supported in part by scholarship from Ewha Womans University.
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border.However,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts...
关键词：OSTEOCLAST inhibited traffic 
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