BERGENIN

作品数：13被引量：41H指数：4
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相关机构：厦门大学中国科学院云南大学兰州大学更多>>
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Research Progress on Rodgersia and Predictive Analysis on its Quality Markers
《World Journal of Traditional Chinese Medicine》2023年第3期243-257,共15页Ling-Ling Chu Bin Li Jia Wu Ling Jiang Xu-Dong Zhou Wen-Bing Sheng Cai-Yun Peng Salman Zafar Ping-An Liu Wei Wang 
financially supported by the Natural Science Foundation of Hunan province(2020JJ4463,2020JJ4064,and 2021JJ30502);Changsha Municipal Natural Science Foundation(kq2014092);Open Fund of First-class Pharmacy Discipline of Hunan University of Chinese Medicine(2020YX02)。
Rodgersia is a traditional Chinese medicine that contains a variety of chemical constituents,including flavonoids,terpenoids,phenylpropanoids,gallic acid derivatives,steroids,volatile oils,and tannins,with anti-inflam...
关键词：BERGENIN chemical constituents pharmacological activity quality marker Rodgersia 
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis被引量：7
《Acta Pharmacologica Sinica》2022年第4期963-976,共14页Ling Yang Yun Zheng Yu-meng Miao Wen-xin Yan Yan-zhi Geng Yue Dai Zhi-feng Wei 
This work was supported by the National Natural Science Foundation of China(No.81773970);the 2019 Outstanding Young Backbone Teacher Project of Jiangsu University“Green Blue Project”.
Bergenin is a natural PPARγ agonist that can prevent neutrophil aggregation, and often be used in clinics for treating respiratory diseases. Recent data show that Th17 cells are important for neutrophil aggregation a...
关键词：immunity-related diseases neutrophilic asthma Th17 differentiation GLUTAMINOLYSIS GLS1 BERGENIN 
Inhibitory Effect of Bergenin on TLR-4/NF-κB Signal Pathway in Reducing Allergic Rhinitis in Mice
《Medicinal Plant》2021年第5期56-59,共4页Weiming WU Pengfei GE Jianqiao LI Yuefeng WANG 
[Objectives]To explore the effect and possible mechanism of bergenin in relieving allergic rhinitis(AR)in mice.[Methods]50 C57/BL6 mice were randomly divided into blank group(n=10),model group(n=10)and high(100 mg/kg)...
关键词：Allergic rhinitis BERGENIN Inflammatory response TLR-4/NF-κB signal pathway 
Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate被引量：3
《Journal of Integrative Medicine》2019年第3期192-204,共13页Sandip B.Bharate Vikas Kumar Sonali S.Bharate Bikarma Singh Gurdarshan Singh Amarinder Singh Mehak Gupta Deepika Singh Ajay Kumar Surjeet Singh Ram A.Vishwakarma 
financially supported by CSIR 12th Five Year Plan project BSC-0205;CSIR-Phytopharmaceutical Mission Project HCP010;CSIR-YSA (Young Scientist Award,P90807) Research Grant;the fellowship from Department of Biotechnology,India (GAP-2158).IIIM publication number: ⅢM/2222/2018
Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a pre...
关键词：BOTANICAL PRECLINICAL candidate UIM-160 Bergenia ciliata Arthritis GASTRORETENTIVE sustained release formulation BERGENIN 
Rice spouted bed for manufacturing inclusion complexes of Endopleura uchi L extracts in β-cyclodextrin
《Particuology》2019年第1期208-215,共8页L.V.D. Freitas A.C.R. Montes E.I.A. Campos E.C. Conceicao L.A. Tacon A.D. Lanchote L.A.P.Freitas 
Uxi (Endopleura uchi) is a plant from the Brazilian Amazon. It has many biological activities that are attributed to its main active component, bergenin (BG), which has low water solubility. The aim of this work was t...
关键词：BERGENIN CHROMATOGRAPHY YIELD Active loss SOLUBILITY 
DPPH antiradical scavenging, anthelmintic and phytochemical studies of Cissus poulnea rhizomes被引量：1
《Asian Pacific Journal of Tropical Medicine》2018年第4期280-284,共5页Jean Noel Nyemb Roland Ndoubalem Emmanuel Talla Alembert Tiabou Tchinda Dieudonne Ndjonka Celine Henoumont Sophie Laurent Joseph Tanyi Mbafor 
Objective: To investigate the phytochemical constituents, antioxidant and anthelmintic activities of the crude methanol extract of Cissus populnea(C. populnea) rhizomes. Methods: Phytochemical screening was performed ...
关键词：Cissus populnea Onchocerca ochengi Antioxidant Phenolic compounds Phytochemical constituent BERGENIN 
Comparative pharmacokinetics of bergenin,a main active constituent of Saxifraga stolonifera Curt.,in normal and hepatic injury rats after oral administration被引量：10
《Chinese Journal of Natural Medicines》2016年第10期776-782,共7页PAN Rong-Hua HE Hong-Mei DAI Yue XIA Yu-Feng 
supported by Health Innovation Personnel Training Project of Changzhou City(No.CWKJ 2010-368);Changzhou High Level Health Personnel Training Project
Bergenin, isolated from the herb of Saxifrage stolonifera Curt.(Hu-Er-Cao) has hepatoprotective, anti-inflammatory, antitussive, and neuroprotective activities. The aim of the present study was to establish a simple, ...
关键词：BERGENIN Saxifrage stolonifera Curt HPLC PHARMACOKINETIC Hepatic injury 
Synthesis and cytotoxic activity of 3, 4, 11-trihydroxyl modified derivatives of bergenin被引量：3
《Chinese Journal of Natural Medicines》2014年第12期929-936,共8页YAN De-Biao ZHANG Dong-Ping LI Ming LIU Wen-Yuan FENG Feng DI Bin GUO Qing-Long XIE Ning 
supported by the Natural Science Foundation of China(Nos.81274064 and 81373956);the National Fund for Fostering Talents of Basic Science(NFFTBS)(No.J1030830);the Science and Technology Supporting Project of Xinjiang(No.201291160)
To synthesize a series of 3-, 4-, and/or 11-trihydroxy modified bergenin derivatives and evaluated their cytotoxic activity in vitro. The phenolic hydroxyl groups of bergenin were protected by benzyl groups with benzy...
关键词：BERGENIN 3- 4- and/or 11-trihydroxyl modified derivatives Cytotoxic activity Structure-activity relationships 
LC-MS/MS determination and pharmacokinetic study of bergenin, the main bioactive component of Bergenia purpurascens after oral administration in rats被引量：6
《Journal of Pharmaceutical Analysis》2013年第4期229-234,共6页Bao-Hong Li Jin-Dong Wu Xiang-Lu Li 
supported by the Natural Science Foundation of Guangdong Province (Nos. 9151008018000003)
Bergenin, a C-glucoside of 4-O-methyl gallic acid from Bergenia purpurascens, is a naturally antitussive and expectorant agent. A rapid and sensitive liquid chromatography tandem mass spectrometry （LC-MS/MS） method ...
关键词：BERGENIN Bergenia purpurascens PHARMACOKINETICS Rat plasma LC-MS/MS 
Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex被引量：11
《Acta Pharmacologica Sinica》2010年第1期127-136,共10页Xuan QIN Yang YANG Ting-ting FAN Tao GONG Xiao-ning ZHANG Yuan HUANG 
Aim： To prepare a bergenin-phospholipid complex （BPC） to increase oral bioavailability of the drug. Methods： In order to obtain the acceptable BPC, a spherical symmetric design-response surface methodology was use...
关键词：BERGENIN phospholipid complex spherical symmetric design-response surface methodology physicochemical properties BIOAVAILABILITY 
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