Inhibitory Effect of Bergenin on TLR-4/NF-κB Signal Pathway in Reducing Allergic Rhinitis in Mice  

作　　者：Weiming WU Pengfei GE Jianqiao LI Yuefeng WANG 

机构地区：[1]Guangxi Wuzhou Red Cross Hospital, Wuzhou 543002, China [2]The Second Affiliated Hospital of Guilin Medical University, Guilin 541004, China [3]Guilin Medical University, Guilin 541199, China

出　　处：《Medicinal Plant》2021年第5期56-59,共4页药用植物：英文版

摘　　要：[Objectives]To explore the effect and possible mechanism of bergenin in relieving allergic rhinitis(AR)in mice.[Methods]50 C57/BL6 mice were randomly divided into blank group(n=10),model group(n=10)and high(100 mg/kg),medium(50 mg/kg)and low(25 mg/kg)dose bergenin groups with 10 mice in each group.Except for the blank group,the other mice were sensitized by basic ways combined with attack to replicate the AR model.From the 15th d of modeling(from the second d after the end of the basic modeling),the drug group was given bergenin orally for 15 d,and the blank group and model group were given the same volume of normal saline once a day.24 h after the last establishment of the model,the content of interleukin 4(IL-4),IL-6,TNF-αand IL-1βin nasal lavage fluid and serum of mice in each group was detected by ELISA.The expression of TLR-4,NF-κB and p-NF-κB in nasal mucosa of mice was detected by Western blot.[Results]Compared with the blank group,the content of inflammatory factors IL-4,IL-6,TNF-αand IL-1βin nasal lavage fluid and serum of model group was significantly increased,and the protein expression of TLR-4 and p-NF-κB was significantly increased.After the intervention of bergenin,the content of IL-4,IL-6,TNF-αand IL-1βin nasal lavage fluid and serum and TLR-4 and p-NF-κB protein in tissue was significantly inhibited in bergenin group.[Conclusions]Bergenin can effectively reduce allergic inflammation in AR model mice,and its mechanism may be related to inhibition of inflammation and down-regulation of TLR-4/NF-κB signal pathway.

关 键 词：Allergic rhinitis BERGENIN Inflammatory response TLR-4/NF-κB signal pathway 

分 类 号：R73[医药卫生—肿瘤]