Enhancing the therapeutic efficacy of photodynamic therapy in colon cancer based on an ECN-mediated targeted drug delivery strategy  

作　　者：Kai Wang Huihui Bian Tao Ye Fusheng Shang Chenxi Zhang Dagui Chen Li Su Heng Yin Liang Zhao 

机构地区：[1]Shanghai Baoshan Luodian Hospital,School of Medicine,Shanghai University,Shanghai 201908,China [2]Institute of Translational Medicine,Shanghai University,Shanghai 200444,China [3]Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine,Wuxi 214000,China

出　　处：《Nano Research》2025年第3期417-428,共12页纳米研究(英文版)

基　　金：supported in part by grants from the National Natural Science Foundation of China(No.81981340417 to L.S.,No.81973878 to H.Y.);the Foundation of Shanghai Municipal Commission of Science and Technology(No.21S21901700);the Foundation of Jiangsu CM Clinical Innovation Center of Degenerative Bone&Joint Disease(Jiangsu science and education of traditional Chinese medicine[2021]No.4).

摘　　要：Photodynamic therapy(PDT)has attracted considerable interest in tumor treatment due to its precise temporal and spatial control.However,the off-target effects of photosensitizers and the hypoxic tumor microenvironment limit the production of reactive oxygen species(ROS),reducing PDT effectiveness.To address this challenge,we utilized Escherichia coli Nissle 1917(ECN)as host cells and employed tannate(TA)and FeCl_(3)in a bio-warp method to encapsulate IR775 on the surface of ECN forming TA@Fe@IR775@ECN(notes as T@I@E).At the tumor site,Fe^(3+)decomposes H_(2)O_(2)to release O_(2)within the tumor microenvironment,which interacts with IR775 to increase ROS production locally.Compared to non-living drug delivery methods,T@I@E actively targets tumor cells,achieving approximately 6-fold higher accumulation of IR775 at the tumor site and alleviating tumor hypoxic to enhance PDT efficacy.The favorable biocompatibility of T@I@E further supports its potential for clinical application,establishing T@I@E as a promising candidate for tumor therapy as a living material.

关 键 词：NANOCARRIERS photodynamic therapy Escherichia coli Nissle 1917 targeted drug delivery cancer therapy 

分 类 号：R743.34[医药卫生—神经病学与精神病学]