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PROTEINS: 作品数：737被引量：1883H指数：19; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：祝莉莉何光存陈荣智黄臻翁清妹更多>>; 相关机构：北京大学第二军医大学中国科学院复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Role of PFKM lactylation in glycolysis regulation in endometrial cancer cells: 《Genes & Diseases》2025年第3期27-30,共4页Bin Wang Jian Ma Di Yang; supported by the National Natural Science Foundation of China(No.82203469);the Liaoning Province Joint Fund General Project(China)(No.2023-MSLH-166).; The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial...; 关键词：lactic acid PFKM lactylation endometrial cancer ec reprogramming glucose metabolism glycolysis regulation metabolic process tumor cells modifying key proteins

Analysis of the roles of MAD proteins in the wing dimorphism of Nilaparvata lugens: 《Insect Science》2025年第2期515-529,共15页Miaomiao Tian Zeiwei Lu Jiguang Luo Huilin Han Dong Wen Muhua Zhao Zhihui Zhu Hongxia Hua; supported by a grant from the National Natural Science Foundation of China(32172396).; Wing dimorphism in Nilaparvata lugens is controlled by the insulin-like growth factor 1(IGF-1)signaling–Forkhead transcription factors(IIS-FoxO)pathway.However,the role of this signal in the wing development program ...; 关键词：IIS-FoxO pathway Nilaparvata lugens NlmadI Nlmad2 wing dimorphism

Recent Advances in Mass Spectrometry-based Separation of Native Proteins: 《Chemical Research in Chinese Universities》2025年第2期211-221,共11页JIA Fanyu JIANG Ting XU Wei; supported by the Beijing Institute of Technology Research Fund Program for Young Scholars,China(No.XSQD-6120230051).; Native proteins refer to proteins that exist in their natural state, have a correctly folded three-dimensional structure, and have biological functions. Characterization of protein higher-order structure and protein-p...; 关键词：Native mass spectrometry Protein separation Liquid chromatography Capillary electrophoresis Protein structure Protein-protein interaction Free-flow electrophoresis

Evaluation of physicochemical and functional properties of protein isolates from 5 edible mushroom species: 《Food Science and Human Wellness》2025年第2期671-682,共12页Zheng Qian Mengdie Yang Xiao Chen Qiping Zhan Lei Zhong Qiuhui Hu Liyan Zhao; supported by the special fund of Jiangsu Province for the transformation of scientific and technological achievements(BA2021062);Jiangsu agricultural science and technology independent innovation fund(CX(22)2007)。; Edible mushroom proteins are the promising ones with the advantages of complete essential amino acid profile and multiple functional activities.To reinforce their applications in functional food development,this study...; 关键词：Edible mushroom proteins Physicochemical properties Functional properties Gelling properties

Biophysical and NMR analysis reveals binding affinity between HAX1 and CLPB proteins: 《Magnetic Resonance Letters》2025年第1期12-21,共10页Huiqin Zhang Yong Liu Yunyan Li Maosen Ruan Shu Zhou Junfeng Wang Jing Yang; supported by grants from the Special Foundation of President of the Chinese Academy of Sciences(Grant No.,YZJJ2020QN27,YZJJ2021QN33);Anhui Provincial Natural Science Foundation(Grant No.,2108085MC79).; HCLS1-associated protein X-1(HAX1)is a multifunctional mitochondrial protein involved in the regulation of apoptosis,a crucial process of programmed cell death,and mRNA processing.Despite its significance,limited stru...; 关键词：HAX1 CLPB Protein interaction Biophysical characterization NMR spectroscopy

Progress of research on glucose transporter proteins in hepatocellular carcinoma: 《World Journal of Hepatology》2025年第3期77-89,共13页Zheng Ruan Yan Wang Lei Shi Xiao-Jun Yang; Hepatocellular carcinoma(HCC)is a malignant tumour with high prevalence and mortality rate worldwide.Metabolic reprogramming of cancer cells may be a major factor in the process of this disease.Glucose transporter pro...; 关键词：Hepatocellular carcinoma Glucose transporter protein Metabolic repro-gramming Therapeutic target Drug resistance

SARS-CoV-2 proteins show great binding affinity to resin composite monomers and polymerized chains: 《World Journal of Experimental Medicine》2025年第1期96-103,共8页Pedro Henrique Sette-de-Souza Moan Jéfter Fernandes Costa Boniek Castillo Dutra Borges; BACKGROUND Due to saliva and salivary glands are reservoir to severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),aerosols and saliva droplets are primary sources of cross-infection and are responsible for the...; 关键词：Composite resins COVID-19 SARS-CoV-2 Dental restorations Molecular docking simulation DENTISTRY

Computational interrogation of natural compounds identified resveratrol-3-O-D-glucopyranoside as a potential inhibitor of essential monkeypox virus proteins: 《Intelligent Medicine》2025年第1期5-13,共9页Oluwafemi A.Adepoju Ammar Usman Danazumi Lamin BS Dibba Bashiru Ibrahim Salahuddin Iliyasu Gital Joseph Gideon Ibrahim Maliyogbinda L.Jibrailu Emmanuel O.Balogun; supported by the Fogarty International Center of the National Institutes of Health(Grant No.K43TW012015).; Background Monkeypox has become a significant public health concern owing to the recent epidemics and associated morbidity.The treatment is limited by the availability of drugs,especially in endemic communities.Comput...; 关键词：Monkeypox virus Drug discovery Computational methods DOCKING Molecular dynamics simulation SuperNatural compounds

Mining Bovine Milk Proteins for DPP-4 Inhibitory Peptides Using Machine Learning and Virtual Proteolysis: 《Research》2025年第1期410-420,共11页Yiyun Zhang Yiqing Zhu Xin Bao Zijian Dai Qun Shen Liyang Wang Yong Xue; supported by the National Key Research and Development Project(2018YFE0206300-02).; Dipeptidyl peptidase-IV(DPP-4)enzyme inhibitors are a promising category of diabetes medications.Bioactive peptides,particularly those derived from bovine milk proteins,play crucial roles in inhibiting the DPP-4 enzym...; 关键词：DPP inhibitors virtual proteolysis techniquesfive machine learning virtual proteolysis bovine milk proteins bovine milk proteinsplay bioactive peptides

Super-resolution microscopy:Shedding new light on blood cell imaging: 《Journal of Innovative Optical Health Sciences》2025年第1期29-53,共25页Huan Deng Yan Ma Yu-Hui Zhang; supported by the following grants:National Key R&D Program of China(Grant no.2022YFC3401100);National Natural Science Foundation of China(Grant nos.32271428,92054110,32201132 and 31600692).; Blood cells are the most integral part of the body,which are made up of erythrocytes,platelets and white blood cells.The examination of subcellular structures and proteins within blood cells at the nanoscale can provi...; 关键词：Super-resolution imaging blood cells subcellular structure PROTEINS

PROTEINS