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机构地区:[1]Department of Gynecology,Liaoning Cancer Hospital and Institute,Cancer Hospital of China Medical University,Shenyang,Liaoning 110042,China [2]Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang,Liaoning 110004,China [3]Department of Obstetrics and Gynecology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China
出 处:《Genes & Diseases》2025年第3期27-30,共4页基因与疾病(英文)
基 金:supported by the National Natural Science Foundation of China(No.82203469);the Liaoning Province Joint Fund General Project(China)(No.2023-MSLH-166).
摘 要:The incidence of endometrial cancer(EC)is increasing,particularly in high-risk cases with poor prognosis.1 Reprogramming glucose metabolism is the main feature of energy metabolism in EC cells,resulting in substantial lactate accumulation.2 Recent research indicates that the accumulation of lactic acid during the metabolic process can serve as a substrate.3 The high concentration of lactate accumulated by metabolites can promote the malignant progression of tumor cells by modifying key proteins through lactylation.
关 键 词:lactic acid PFKM lactylation endometrial cancer ec reprogramming glucose metabolism glycolysis regulation metabolic process tumor cells modifying key proteins
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