ENHANCER

作品数：221被引量：519H指数：9
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Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction
《Neural Regeneration Research》2025年第9期2464-2479,共16页Said Hashemolhosseini Lea Gessler 
supported by the German Research Council(Deutsche Forschungsgemeinschaft,HA3309/3-1/2,HA3309/6-1,HA3309/7-1)。
Skeletal muscles are essential for locomotion,posture,and metabolic regulation.To understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways...
关键词：canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway MYOGENESIS MYOTUBE neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1) 
A novel Wnt/β-catenin signaling gene signature for progression and metastasis of gastric cancer
《Oncology Research》2025年第5期1199-1215,共17页JIA CHEN FEI JIANG KAIYI NIU HAODONG ZHAO LI LI HONGZHU YU 
funded by the Natural Science Research Project of Anhui Educational Committee(2023AH050650);the Research Fund Program of Anhui Medical University(2023xkj176).
Backgrounds:As cancer progresses through various stages of malignancy,metastasis,and drug resistance,the Wnt/-catenin signaling is frequently dysregulated.Despite advancements in medical technology and therapeutic str...
关键词：Gastric Cancer(GC) Signature genes Prognosis Carboxypeptidase Z(CPZ) Adipocyte Enhancer Binding Protein 1(AEBP1) 
EZH2,via an association with KDM2B,modulates osteogenic differentiation of root apical papillary stem cells
《World Journal of Stem Cells》2025年第4期99-112,共14页Hui-Yue Xu Yan-Tong Wang Hao-Qing Yang Yang-Yang Cao Zhi-Peng Fan 
Supported by National Key Research and Development Program,No.2022YFA1104401;Beijing Natural Science Foundation,No.7222075;CAMS Innovation Fund for Medical Sciences,No.2019RU020;Innovation Research Team Project of Beijing Stomatological Hospital,No.CXTD202204.
BACKGROUND Stem cells from apical papilla(SCAPs)represent promising candidates for bone regenerative therapies due to their osteogenic potential.However,enhancing their differentiation capacity remains a critical chal...
关键词：Bioactive peptides Bone tissue engineering Enhancer of zeste homolog 2 OSTEOGENIC Apical papillary stem cell 
Magnolol inhibits appetite and causes visceral fat loss through Growth/differentiation factor-15(GDF-15)by activating transcription factor 4-CCAAT enhancer binding proteinγ-mediated endoplasmic reticulum stress responses
《Chinese Journal of Natural Medicines》2025年第3期334-345,共12页Keru Cheng Yanyun Zhou Yilong Hao Shengyun Wu Nanping Wang Peng Zhang Yinfang Wang 
supported by the National Natural Science Foundation of China(Nos.82171552 and 82170479);the Natural Science Foundation of Shanghai Ctiy(No.21ZR1457500);the Science and Technology Bureau of Shanghai Putuo District(No.ptkwws202102).
Magnolol,a compound extracted from Magnolia officinalis,demonstrates potential efficacy in addressing metabolic dysfunction and cardiovascular diseases.Its biological activities encompass anti-inflammatory,antioxidant...
关键词：MAGNOLOL Growth/differentiation factor-15 Activating transcription factor 4 CCAAT enhancer binding proteinγ ENHANCER Metabolic disorder 
Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis
《World Journal of Clinical Cases》2025年第4期56-60,共5页Chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng 
This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the surviva...
关键词：Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging 
An enhancer–promoter-transcription factor module orchestrates plant immune homeostasis by constraining camalexin biosynthesis
《Molecular Plant》2025年第1期95-113,共19页Ying Zhang Meng Tang Yi Zhang Qinglin Cheng Lijiang Liu Wei Chen Jiatao Xie Jiasen Cheng Yanping Fu Bo Li Daohong Jiang Xiao Yu 
This research was supported by the National Natural Science Foundation of China(grant no.32200242 to X.Y.);funds from the National Key Laboratory of Agricultural Microbiology(grant no.AML2023B07 to X.Y.);the National Natural Science Foundation of China(grant no.32130087 to D.J.);the Earmarked Fund for CARS-12(to D.J.);Fundamental Research Funds for the Central Universities(grant no.2662023PY006 and2662023ZKPY001toB.L).
Effective plant defense against pathogens relies on highly coordinated regulation of immune gene expression.Enhancers,as cis-regulatory elements,are indispensable determinants of dynamic gene regulation,but the molecu...
关键词：plant innate immunity ENHANCERS antifungal resistance transcriptional regulation cis-regulatory elements transcription factors 
Gene targets with therapeutic potential in hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2024年第12期4543-4547,共5页Syifaus Shodry Yuliono Trika Nur Hasan Iwal Reza Ahdi Zulvikar Syambani Ulhaq 
Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.Major treatments include liver transplantation,resection,and chemotherapy,but the 5-year recurrence rate remains high.Late dia...
关键词：Hepatocellular carcinoma Enhancer of zeste homolog 2 Target genes Biomarkers Potential therapeutic 
Syn3,a newly developed cyclic peptide and BDNF signaling enhancer,ameliorates retinal ganglion cell degeneration in diabetic retinopathy
《Protein & Cell》2024年第11期858-865,共8页Ke-ran Li Meng-Jia Huan Jin Yao Jia-jun Li Yuan Cao Suyu Wang Mandar TNaik Yuan Fang John Marshall Chang-gong Lan Cong Cao 
supported by the National Natural Science Foundation of China (81922025, 82371473, 82171080, 81970823, 82171461, 81771457, 82271107);by Jiangsu Province Social Development Project (BE2023702);funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
Dear Editor,Diabetic retinopathy(DR)remains a leading cause of irreversible blindness in adults worldwide(Sabanayagam et al.,2019).Increasing evidence suggests that visual deficits are closely associated with neurodeg...
关键词：DEGENERATION RETINOPATHY 
KMT2D deficiency leads to cellular developmental disorders and enhancer dysregulation in neural-crest-containing brain organoids
《Science Bulletin》2024年第22期3533-3546,共14页Ziyun Shan Yingying Zhao Xiuyu Chen Guodong Zhan Junju Huang Xuejie Yang Chongshen Xu Ning Guo Zhi Xiong Fang Wu Yujian Liu He Liu Biyuan Chen Bingqiu Chen Jiaoyang Sun Jiangping He Yiping Guo Shangtao Cao Kaixin Wu Rui Mao Guangming Wu Lihui Lin Xiaobing Zou Jie Wang Jiekai Chen 
supported by National Science Foundation of China(32225012);National Key R&D Program of China(2019YFA0110200);Health@Inno HK Program launched by Innovation Technology Commission of the Hong Kong SAR,China,Youth Innovation Promotion Association,Chinese Academy of Sciences(Jie Wang),National Science Foundation of China(32000414,32000503,and 32000501);The Science and Technology Program of Guangzhou 201804020052 and 202102021039;the Pearl River Talent Recruitment Program(2021ZT09Y233);Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,(GIBHBRP23-01,GIBHBRP23-02);Frontier Science Research Program of the CAS ZDBS-LY-SM007;Science and Technology Planning Project of Guangdong Province,China(2023B1212060050 and 2023B1212120009)。
KMT2D,a H3K4me1 methyltransferase primarily regulating enhancers,is a leading cause of KABUKI syndrome.This multisystem disorder leads to craniofacial and cognitive abnormalities,possibly through neural crest and neur...
关键词：KMT2D ENHANCER NICHE Cerebral organoids Single-cell multiome 
Enhancer of Shoot Regeneration 2(ESR2)regulates pollen maturation and vitality in watermelon(Citrullus lanatus)
《Journal of Integrative Agriculture》2024年第10期3506-3521,共16页Hu Wang Lihong Cao Yalu Guo Zheng Li Huanhuan Niu 
support from the National Key Research and Development Program of China(2022YFD1602000);the National Natural Science Foundation of China(32202514,U22A20498 and 32072596);the Joint Fund of Henan Province Science and Technology Research and Development Plan,China(222103810009);the Science and Technology Innovation Team of Shaanxi,China(2021TD-32);the China Postdoctoral Science Foundation(2022M711064 and 2023M741062).
Watermelon(Citrullus lanatus)holds global significance as a fruit with high economic and nutritional value.Exploring the regulatory network of watermelon male reproductive development is crucial for developing male st...
关键词：ESR2 WATERMELON OVEREXPRESSION pollen maturation pollen vitality 
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