Syn3,a newly developed cyclic peptide and BDNF signaling enhancer,ameliorates retinal ganglion cell degeneration in diabetic retinopathy  

作　　者：Ke-ran Li Meng-Jia Huan Jin Yao Jia-jun Li Yuan Cao Suyu Wang Mandar TNaik Yuan Fang John Marshall Chang-gong Lan Cong Cao 

机构地区：[1]The Affiliated Eye Hospital,Nanjing Medical University,Nanjing 210029,China [2]Department of Ophthalmology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China [3]Department of Molecular Pharmacology,Physiology and Biotechnology,Brown University,Providence,RI 02912,United States [4]Department of Ophthalmology&Vision Science,Eye and ENT Hospital,Shanghai Medical College,Fudan University,Shanghai 200433,China [5]Department of Joint Surgery and Geriatric Orthopedics,Affiliated Hospital of YouJiang Medical University for Nationalities,Guangxi Key Laboratory of Basic and Translational Research of Bone and Joint Degenerative Diseases,Guangxi Biomedical Materials Engineering Research Center for Bone and Joint Degenerative Diseases,Baise 533000,China [6]Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Institution of Neuroscience,Soochow University,Suzhou 215031,China

出　　处：《Protein & Cell》2024年第11期858-865,共8页蛋白质与细胞（英文版）

基　　金：supported by the National Natural Science Foundation of China (81922025, 82371473, 82171080, 81970823, 82171461, 81771457, 82271107);by Jiangsu Province Social Development Project (BE2023702);funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：Dear Editor,Diabetic retinopathy(DR)remains a leading cause of irreversible blindness in adults worldwide(Sabanayagam et al.,2019).Increasing evidence suggests that visual deficits are closely associated with neurodegeneration,especially the synaptic loss and degeneration of retinal ganglion cells(RGCs)(Kern and Barber,2008).Neurotrophic factors play a key role in supporting the survival of RGCs(Kimura et al.,2016)and brain-derived neurotrophic factor(BDNF)stands out as a crucial neurotrophin vital for RGCs(Kimura et al.,2016).In vivo studies have demonstrated that intravitreal administration of BDNF enhances the survival of axotomized RGCs in rats,and astrocytes designed to secrete BDNF promote RGC survival in vitro(Castillo et al.,1994).

关 键 词：DEGENERATION RETINOPATHY 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]