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作品数:571被引量:2622H指数:24
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相关领域:医药卫生生物学更多>>
相关作者:谢安木侯文龙游利陈瑾瑜陈琳更多>>
相关机构:中山大学南华大学青岛大学中南大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>
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Overexpression of the apple m^(6)A demethylase gene MdALKBH1A regulates resistance to heat stress and fixed-carbon starvation
《Journal of Integrative Agriculture》2025年第4期1489-1502,共14页Ru Bao Tianli Guo Zehua Yang Chengyu Feng Junyao Wu Xiaomin Fu Liu Hu Changhai Liu Fengwang Ma 
supported by the earmarked fund for the China Agricultural Research System(CARS-27)。
The pivotal role of N^(6)-methyladenosine(m^(6)A)demethylases in regulating plant stress responses has been widely explored;however,the function of apple m^(6)A demethylases under heat stress and fixed-carbon starvati...
关键词:MdALKBH1A heat stress fixed-carbon starvation TOMATO APPLE 
SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia
《Genes & Diseases》2025年第2期72-75,共4页Akhilesh Kaushal Samrat Roy Choudhury 
supported by grants from the National Institutes of Health (No.P20GM121293)to S.R.C.;funded by the Seeds of Science Award and startup from the University of Arkansas for Medical Sciences (UAMS) and Arkansas Children's Research Institute (ACRI)to S.R.C.
The SET-NUP214 gene fusion is mainly found in patients primarily diagnosed with T-cell acute lymphoblastic leukemia(T-ALL)and rarely in acute myeloid leukemia(AML).1 Patients with the SET-NUP214 fusion protein(referre...
关键词:acute LEUKEMIA cluster 
Overexpression of EspL inhibits autophagy and antigen presentation to promote the intracellular survival of Mycobacterium tuberculosis avirulent strains
《Animal Diseases》2025年第1期43-55,共13页Luxia Cai Yingying Lei Tianyi Xie Yiling Liu Yutong Fan Bing Yang Shuang Dong Gang Cao Xi Chen 
supported by the National Natural Science Foundation of China under grant number U21A20259;the National Key Research and Development Program of China under grant number 2021YFD1800401.
Mycobacterium tuberculosis(Mtb)employs multiple mechanisms,such as phagocytosis and autophagy,to evade innate immune clearance and establish infection.In the present study,we identified the ESX-1 secretion-associated ...
关键词:Mycobacterium tuberculosis EspL PATHOGENICITY AUTOPHAGY Antigen presentation T-cell responses 
Overexpression of rbk affects the biofilm formation, adhesion, and metabolic profile of Lactiplantibacillus paraplantarum LR-1
《微生物学报》2025年第3期1241-1265,共25页YANG Yao SONG Yunlong CHEN Xing LI Xiaoli LONG Haiqi LIU Lei RAO Yu 
四川省科技计划重点研发项目(2023YFN0058);四川省自然科学基金(2023NSFSC1203);甘肃省科技重大专项(23ZDNA007)。
[Objective]Biofilm formation and adhesion are important indicators for evaluating the beneficial effects of probiotics.However,the relationship of specific genes with the biofilm formation and adhesion of Lactiplantib...
关键词:Lactiplantibacillus rbk overexpression BIOFILM ADHESION untargeted metabolomics 
NUF2 overexpression predicts poor outcomes in multiple myeloma
《Genes & Diseases》2025年第1期141-143,共3页Shanshan Zhang Li Zhang Linjing Cai Huan Chen Yuqi Wang Youhai Yuan Hanzhen Zhang Xiaolei Wei 
supported by Natural Science Foundation:of Guangdong,China(No.2024A04J5216);the Technology Project of Guangzhou City(Guangdong,China)(No.202102020937);the Outstanding Youth Development Scheme of Nanfang Hospital,Southern Medical University(Guangdong,China)(No.2019J011).
Multiple myeloma(MM)is the second most common hematologic malignancy and is characterized by the expansion of clonally plasma cells and related organ or tissue damage.1 The clinical behavior,response,and survival of M...
关键词:MYELOMA CLINICAL DAMAGE 
Conferring non-strain-specific resistance to a potyvirus via overexpression of mutant potyviral coat proteins in soybean
《Journal of Integrative Plant Biology》2025年第2期202-204,共3页Sun-Jung Kwon Myung-Hwi Kim Hye Jeong Kim Phu-Tri Tran Young-Soo Chung Kook-Hyung Kim Jang-Kyun Seo 
supported by a grant from Basic Science Research Program(NRF-2022R1A2C1004728)funded by the National Research Foundation of Korea。
Dominant resistance gene(R-gene)-mediated resistance precisely targets specific pathogens,but short-term overcoming of R-gene-mediated resistance is highly possible for viral pathogens with high evolutionary capacity(...
关键词:SOYBEAN resistance DOMINANT 
Overexpression and clinicopathological significance of zinc finger protein 71 in hepatocellular carcinoma
《World Journal of Hepatology》2025年第2期182-199,共18页Kai Qin Dan-Dan Xiong Zhen Qin Ming-Jie Li Qi Li Zhi-Guang Huang Yu-Xing Tang Jian-Di Li Yan-Ting Zhan Rong-Quan He Jie Luo Hai-Quan Wang Shu-Qi Zhang Gang Chen Dan-Ming Wei Yi-Wu Dang 
Supported by Joint Project on Regional High Incidence Diseases Research of Guangxi Natural Science Foundation,No.2024GXNSFAA010057 and No.2024GXNSFAA010085;Natural Science Foundation of Guangxi,China,No.2022GXNSFBA035657;Guangxi Zhuang Autonomous Region Health Commission Self-Financed Scientific Research Project,No.Z20210764;Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine Scientific Research Project,No.GXZYA20230270 and No.GXZYA20240305;Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University(2022).
BACKGROUND Hepatocellular carcinoma(HCC)is one of the most prevalent and aggressive forms of liver cancer,with high morbidity and poor prognosis due to late diagnosis and limited treatment options.Despite advances in ...
关键词:Hepatocellular carcinoma Zinc finger protein 71 IMMUNOHISTOCHEMISTRY Enrichment analysis Immune infiltration 
Corrigendum: Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism
《Neural Regeneration Research》2025年第2期401-401,共1页
In the article titled“Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism,”published on pages 650-656,Issue 3,Volum...
关键词:METABOLISM ENDOTHELIN 
Overexpression of arginase gene CAR1 renders yeast Saccharomyces cerevisiae acetic acid tolerance
《Synthetic and Systems Biotechnology》2024年第4期723-732,共10页Liang Xiong Ya-Ting Wang Ming-Hai Zhou Hiroshi Takagi Jiufu Qin Xin-Qing Zhao 
supported financially by National Key Research and Development Program(No.2022YFE0108500);National Natural Science Foundation of China(No.21978168)to X.-Q.Z;JFQ appreciates the grant from Sichuan Natural Science Foundation(No.2023NSFSC0132).
Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast strains.Therefore,the cellulosic ethanol industry requires yeast strains that can tolerate acetic ...
关键词:Saccharomyces cerevisiae ARGINASE CAR1 Acetic acid tolerance Amino acid metabolism Ethanol production 
Gene editing and overexpression of soybean miR396a reveals its role in salinity tolerance and development
《The Crop Journal》2024年第6期1655-1665,共11页Xiangqian Chen Xuemin Jiang Xianjun Sun Zheng Hu Fei Gao Xiuping Wang Hui Zhang Rui Chen Qiyan Jiang 
supported by the National Key Research and Development Program of China (2021YFD1201603,2023YFD1202900);the Key Research and Development Program of Shandong Province (Agricultural Seed Improvement Project) (ZDYF2023LZGC001);the Key Research and Development Program of Hainan Province (ZDYF2022XDNY135);the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (ASTIP No.CAAS-ZDRW202407,01-ICS-02).
MicroRNAs(miRNAs)are versatile regulators of gene expression at both the transcription and posttranscription levels.The microRNA miR396 plays vital roles in growth,development,and resistance to abiotic stresses in man...
关键词:Glycine max Gm-miR396a Salt stress CRISPR/Cas9 
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