ARGINASE

作品数：26被引量：86H指数：6
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相关领域：医药卫生更多>>
相关作者：商蓉郁刘建文许玲刘嘉湘陈洪越更多>>
相关机构：第三军医大学上海中医药大学吉林大学中山大学更多>>
相关期刊：《Journal of Biomedical Research》《Neural Regeneration Research》《Advances in Alzheimer's Disease》《中国中西医结合杂志》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金公益性行业(农业)科研专项更多>>
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Overexpression of arginase gene CAR1 renders yeast Saccharomyces cerevisiae acetic acid tolerance
《Synthetic and Systems Biotechnology》2024年第4期723-732,共10页Liang Xiong Ya-Ting Wang Ming-Hai Zhou Hiroshi Takagi Jiufu Qin Xin-Qing Zhao 
supported financially by National Key Research and Development Program(No.2022YFE0108500);National Natural Science Foundation of China(No.21978168)to X.-Q.Z;JFQ appreciates the grant from Sichuan Natural Science Foundation(No.2023NSFSC0132).
Acetic acid is a common inhibitor present in lignocellulose hydrolysate,which inhibits the ethanol production by yeast strains.Therefore,the cellulosic ethanol industry requires yeast strains that can tolerate acetic ...
关键词：Saccharomyces cerevisiae ARGINASE CAR1 Acetic acid tolerance Amino acid metabolism Ethanol production 
Tracking interactions between TAMs and CAFs mediated by arginase-induced proline production during immune evasion of HCC
《Aggregate》2024年第3期439-449,共11页Chuanchen Wu Yuantao Mao Xinru Qi Xin Wang Ping Li Wen Zhang Bo Tang 
National Natural Science Foundation of China,Grant/Award Numbers:22134004,22074083,21927811;Key Research and Development Program of Shandong Province,Grant/Award Number:2018YFJH0502;Natural Science Foundation of Shandong Province of China,Grant/Award Numbers:ZR2020ZD17,ZR2023YQ016,ZR2021QB042;Local Science and Technology Development Fund Guided by the Central Government of Shandong Province,Grant/Award Number:YDZX2022012;The Major Science and Technology Innovation Project of Shandong Province,Grant/Award Number:2021ZDSYS09。
Synergistic changes between tumor-associated macrophages(TAMs)and cancer-associatedfibroblasts(CAFs)aggravated immune evasion of hepatocellular carci-noma(HCC),however,the underlying molecular mechanisms remain elusiv...
关键词：ARGINASE fluorescent probe immune evasion tumor-associatedfibroblasts tumor-associated macrophages 
TAK1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection
《Infectious Microbes & Diseases》2023年第3期127-136,共10页Xiankai Cao Kossiwa C.Kokou Shi Yu Mengdan Chen Junling Niu HervéLecoeur Eric Prina Gerald F.Späth Guangxun Meng 
supported by grants from the Institute Pasteur International Direction,International Partnership Program(153831KYSB20190008);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29030303);the National Key Basic Research Program(2018YFA0507300,2022YFC2304700,2022YFC2303200);the National Natural Science Foundation of China(81830049,92269202);the Shanghai Municipal Science and Technology Major Project(#2019SHZDZX02);the Research Leader Program(#20XD1403900);the Innovation Capacity Building Project of Jiangsu province(BM2020019)。
Leishmania parasites mainly infect macrophages and may cause severe immunopathologies in their host,which are called leishman-iases.In the current work,we infected human and mouse macrophages in vitro with Leishmania ...
关键词：TAK1 MACROPHAGE Leishmania major arginase 1 nitric oxide 
MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation:implications for innovative type 2 diabetes mellitus management
《World Journal of Diabetes》2023年第9期1334-1340,共7页Konstantinos I Papadopoulos Alexandra Papadopoulou Tar-Choon Aw 
Type 2 diabetes mellitus(T2DM)is a lifelong condition and a threat to human health.Thorough understanding of its pathogenesis is acutely needed in order to devise innovative,preventative,and potentially curative pharm...
关键词：Angiotensin II Angiotensin II type 1 receptor Arginase 2 L-type calcium channel Mineralocorticoid receptor MiRNA-155 Renin-angiotensin aldosterone system Type 1/2 diabetes mellitus VERAPAMIL 
Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第11期1658-1670,共13页Yi Yu Yuanyuan Ren Caihua Wang Zhuozhuo Li Fanglin Niu Zi Li Qiang Ye Jiangxia Wang Yuan Yan Ping Liu Lu Qian Yuyan Xiong 
This work was supported by grants from the National Natural Science Foundation of China(No.82103589);the Natural Science Foundation of Shaanxi Province(Nos.2020JQ-611 and 2021JQ-458);the Special Scientific Research Plan for Emergency Public Health Safety 2020 of Shaanxi Provincial Department of Education(No.20JG034);Scientific Research Foundation 2019 for the Returned Overseas Scholars of Shaanxi Province and High-level Talent Programs of Shaanxi Province。
Ferroptosis,a newly defined and iron-dependent cell death,morphologically and biochemically differs from other cell deaths.Melanoma is a serious type of skin cancer,and the poor efficacy of current therapies causes a ...
关键词：Arginase 2 SORAFENIB ferroptosis lipid peroxidation MELANOMA 
Mycobacterium Lrp/AsnC family transcriptional factor modulates the arginase pathway as both a sensor and a transcriptional repressor被引量：1
《Journal of Genetics and Genomics》2021年第11期1020-1031,共12页Shuangquan Yan Junfeng Zhen Yuzhu Li Yu Huang Xuefeng Ai Yue Li Andrea Stojkoska Xue Huang Cao Ruan Jiang Li Lin Fan Jianping Xie 
the National Natural Science Foundation of China(82072246,81871182);National key R&D plan(2016YFC0502304).
L-Arginine is the precursor of nitric oxide(NO),a host immune effector against intracellular pathogens including Mycobacterium tuberculosis(M.tb).Pathogens including M.tb have evolved various strategies targeting argi...
关键词：Mycobacterium tuberculosis Lrp/AsnC family transcriptional regulator REPRESSOR Arginine Arginase pathway Persistence 
Vagal-α7nAChR signaling is required for lung anti-inflammatory responses and arginase 1 expression during an influenza infection被引量：2
《Acta Pharmacologica Sinica》2021年第10期1642-1652,共11页Zhao-wei Gao Ling Li Yuan-yuan Huang Cai-qi Zhao Shuang-jia Xue Jie Chen Zhong-zhou Yang Jin-fu Xu Xiao Su 
This work is supported by NSFC programs 81730001,91942305,and 81970075;the Strategic Leading Project(B)of CAS XDPB0303;the International Collaboration project of CAS 153831KYSB20170043;Innovative Research Team of High-level Local Universities in Shanghai.
Vagal circuit-α7 nicotinic acetylcholine receptor(α7nAChR,coded by Chrna7)signaling can modulate lung proinflammatory responses.Arginase 1(ARG1)plays a crucial role in the resolution of lung inflammation.However,whe...
关键词：vagus circuits α7nAChR lung inflammation arginase 1 influenza A virus 
Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish被引量：15
《Animal Nutrition》2021年第3期716-727,共12页Qingchao Wang Zhen Xu Qinghui Ai 
funded by National Natural Science Foundation of China(Grant No.31802317)
Fish have limited ability in endogenous biosynthesis of arginine.Arginine is an indispensable amino acid for fish,and the arginine requirement varies with fish species and fish size.Recent studies on fish have demonst...
关键词：Arginine metabolism ARGINASE IMMUNONUTRITION Nitric oxide Target of rapamycin signaling 
Role of the metabolism of branched-chain amino acids in the development of Alzheimer’s disease and other metabolic disorders被引量：12
《Neural Regeneration Research》2020年第8期1460-1470,共11页Baruh Polis Abraham O.Samson 
supported by a Marie Curie CIG Grant 322113;a Leir Foundation Grant;a Ginzburg Family Foundation Grant;a Katz Foundation Grant to AOS
Alzheimer’s disease is an incurable chronic neurodegenerative disorder and the leading cause of dementia,imposing a growing economic burden upon society.The disease progression is associated with gradual deposition o...
关键词：ARGINASE ARGININE branched-chain aminotransferase BCAAs DEMENTIA mTOR norvaline urea cycle VALINE 
Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans被引量：3
《Journal of Genetics and Genomics》2020年第3期145-156,共12页Ruofeng Tang Xin Wang Junxiang Zhou Fengxia Zhang Shan Zhao Qiwen Gan Liyuan Zhao Fengyang Wang Qian Zhang Jie Zhang Guodong Wang Chonglin Yang 
supported by grants from the National Scicnce Foundation of China(91954204 and 31730053);the National Basic Research Program of China(2017YFA0503403)。
Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol,defects in which may lead to hyperargininemia,a devastating developmental disorder.It is largely unknown if defective argini...
关键词：ARGININE ARGINASE Hyperargininemia Mitochondrial homeostasis C.elegans 
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