REPRESSOR

作品数：64被引量：275H指数：8
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相关领域：医药卫生更多>>
相关作者：黎怀星王桂芳孙树汉修清玉施柯更多>>
相关机构：北京协和医学院第二军医大学麻省理工学院清华信息科学与技术国家实验室更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds
《Neural Regeneration Research》2025年第4期1009-1014,共6页Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa 
supported by Telethon Italy award GGP15225(to RC and GM);Italian Ministry of Health award RF-2016-02362950(to RC and CZ);the CJD Foundation USA(to RC);the Associazione Italiana Encefalopatie da Prioni(AIEnP)(to RC).
PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals.PrPSccan adopt different patho...
关键词：anti-prion drug anti-PrPC antibody antisense oligonucleotide NEURODEGENERATION pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor 
Research Progress of EZH2 in Tumors and Translational Perspectives
《Proceedings of Anticancer Research》2025年第2期43-55,共13页Yu Tian Hu-Li Li You-Fu Pan 
supported by the National Natural Science Foundation of China(32360166,31760321).
Enhancer of zeste homolog 2(EZH2)is a key epigenetic regulatory protein and enzyme catalytic subunit of the polycomb repressor complex 2(PRC2),responsible for catalyzing the trimethylation of histone H3K27 and subsequ...
关键词：EZH2 Polycomb repressor complex 2 Cell signaling INHIBITOR 
A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1
《mLife》2025年第1期96-100,共5页Yujie Zhang Wenjun Wu Ke Huang Fang-Jie Zhao 
supported by the Natural Science Foundation of China(Grant Nos.42077210 and 41930758 to Ke Huang and Fang-jie Zhao,respectively).
Impact statement Arsenic is the most common toxic metalloid in the environment.Nearly all organisms have genes for arsenic detoxification.Arsenic detoxification genes are frequently organized in chromosomal or plasmid...
关键词：ars operon Ars responsive toxic metalloid evolution relationship ArsR transcriptional repressor arsenic resistance arsr repressor 
Sucrose induces flowering by degradation of the floral repressor Ghd7 via K48-linked polyubiquitination in rice
《Journal of Integrative Plant Biology》2024年第12期2683-2700,共18页Lae-Hyeon Cho Jinmi Yoon Gibeom Baek Win Tun Hyeok Chan Kwon Dae-Woo Lee Seok-Hyun Choi Yang-Seok Lee Jong-Seong Jeon Gynheung An 
supported in part by grants from the National Research Foundation of Korea (2020R1A2C2006826 to G.A.,2021R1C1C2007906 to J.Y.,2023R1A2C1003142 to J.-S.J.,and RS-2023-00208027 to L.-H.C.);the Rural Development Administration (RDA),Republic of Korea (RS-2022-RD010220)
Sucrose functions as a signaling molecule in several metabolic pathways as well as in various developmental processes.However,the molecular mechanisms by which sucrose regulates these processes remain largely unknown....
关键词：flowering time Ghd7 IPI1 K48-linked poly-ubiquitination RICE SUCROSE 
Repressor elements provide insights into tissue development and phenotypes in pigs
《Zoological Research》2024年第6期1313-1326,共14页Yue-Dong Zhang Chao Guo Hang Liu Yun Gao Yongjun Tan Longjian Niu Ligang Wang Lixian Wang David MIrwin Chunhui Hou Zhong-Yin Zhou Ya-Ping Zhang 
supported by the Science&Technology Department of Yunnan Province (202102AE090039);National Natural Science Foundation of China (32100502);Yunnan Revitalization Talent Support Program Young Talent Project;CAS “Light of West China”Program;Spring City Plan:High-level Talent Promotion and Training Project of Kunming (2022SCP001);CAS Key Technology Talent Program to Y.G。
Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately understood.In the present study,we employed H3K27me3 profiling,assay...
关键词：Repressor elements Super repressor elements SILENCER Regulatory model Tissue development KLF4 Pig 
A pair of nuclear factor Y transcription factors act as positive regulators in jasmonate signaling and disease resistance in Arabidopsis被引量：1
《Journal of Integrative Plant Biology》2024年第9期2042-2057,共16页Chuyu Lin Chenghao Lan Xiaoxiao Li Wei Xie Fucheng Lin Yan Liang Zeng Tao 
supported by National Natural Science Foundation of China(31970534);Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(2021C02064);the National Youth Talent Support Program。
The plant hormone jasmonate(JA)regulates plant growth and immunity by orchestrating a genome-wide transcriptional reprogramming.In the resting stage,JASMONATE-ZIM DOMAIN(JAZ)proteins act as main repressors to regulate...
关键词：histone demethylase jasmonate response JAZ repressor necrotrophic resistance nuclear factor 
Removal of the C4-domain preserves the drought tolerance enhanced by CsMYB4a and eliminates the negative impact of this transcription factor on plant growth
《aBIOTECH》2024年第3期368-374,共7页Mingzhuo Li Guoliang Ma Xiu Li Lili Guo Yanzhi Li Yajun Liu Wenzhao Wang Xiaolan Jiang De-Yu Xie Liping Gao Tao Xia 
Natural Science Foundation of China(Grant No.32372756,No 32072621);the National Science Basic Research Program of Shanxi(2022JQ-194)for supporting this research.
The MYB4 transcription factor family regulates plant traits.However,their overexpression often results in undesirable side effects like growth reduction.We have reported a green tea(Camellia sinensis)MYB4 transcriptio...
关键词：Tea MYB4 repressor Development Carbohydrate metabolism Drought stress C4-domain 
A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor被引量：2
《Journal of Integrative Plant Biology》2024年第6期1106-1125,共20页Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K.C.Rose Wensuo Jia 
financially supported by the National Key Research and Development Program(2022YFD2100102);the Tianchi Talent Program(2023),the Beijing Natural Science Foundation(6232019);the National Key Research and Development Program(2019YFD1000200);the Construction of Beijing Science and Technology Innovation and Service Capacity in Top Subjects(CEFFPXM2019_014207_000032)。
It is generally accepted that jasmonate-ZIM domain(JAZ)repressors act to mediate jasmonate(JA)signaling via CORONATINE-INSENSITIVE1(COI1)-mediated degradation.Here,we report a cryptic signaling cascade where a JAZ rep...
关键词：defense response JAZ repressor PHOSPHORYLATION strawberry subcellular translocation 
Unraveling the regulatory network of flower coloration in soybean:Insights into roles of GmMYBA3 and GmMYBR1
《The Crop Journal》2024年第2期443-455,共13页Ruifang Gao Yueqing Li Yanan Wang Xiaotong Shan Siqi Yang Ye Zhang Saiyu Ma Chunbao Zhang Jianchun Qin Li Wang Xiang Gao 
supported by the National Natural Science Foundation of China(32201781,32100211);the Department of Science and Technology of Jilin Province(20220508112RC,20210101005JC);the Fundamental Research Fund for the Central Universities(2412023YQ005);China Agriculture Research System(CARS04)。
Anthocyanins play crucial roles in pollen protection and pollinator attraction in flowering plants.However,the mechanisms underlying flower color determination and whether floral anthocyanin regulators participate in ...
关键词：ANTHOCYANIN Flower color determination MBW complex MYB repressor Pleiotropic regulator 
Carbon Catabolite Repressor UvCreA is Required for Development and Pathogenicity in Ustilaginoidea virens被引量：1
《Rice science》2024年第2期203-214,I0029-I0031,共15页XIE Shuwei SHI Huanbin WEN Hui LIU Zhiquan QIU Jiehua JIANG Nan KOU Yanjun 
the Key Projects of Zhejiang Provincial Natural Science Foundation,China(Grant No.LZ23C130002);the National Natural Science Foundation of China(Grant No.32100161);the Zhejiang Science and Technology Major Program on Rice New Variety Breeding,China(Grant No.2021C02063);the Key R&D Project of China National Rice Research Institute(Grant No.CNRRI-2020-04);the Chinese Academy of Agricultural Sciences under the Agricultural Sciences and Technologies Innovation Program,the Youth innovation Program of Chinese Academy of Agricultural Sciences(Grant No.Y2023QC22);the Joint Open Competitive Project of the Yazhou Bay Seed Laboratory and China National Seed Company Limited(Grant Nos.B23YQ1514 and B23CQ15EP).
The rice false smut disease, caused by Ustilaginoidea virens, has emerged as a significantglobal threat to rice production. The mechanism of carbon catabolite repression plays a crucial role in theefficient utilizatio...
关键词：Ustilaginoidea virens VIRULENCE carbon catabolite repression Oryza sativa rice false smut 
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