The Role of Linker Histone Mutation in Oncogenesis: Molecular Mechanism and Structural Impact  

作　　者：Gege Liu Houfang Zhang Yunhui Peng 

机构地区：[1]Institute of Biophysics and Department of Physics,Central China Normal University,Wuhan,430079,China

出　　处：《BIOCELL》2025年第4期519-538,共20页生物细胞(英文)

基　　金：supported by the National Natural Science Foundation of China(No.12205112);financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE(CCNU24JC012);supported by Natural Science Foundation of Wuhan(No.2024040801020302).

摘　　要：Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer,emphasizing their critical involvement in cancer progression.These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures,which in turn significantly affect epigenetic regulatory processes.In this review,we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties,influencing their binding to nucleosomes,and overall chromatin architecture.Additionally,we explore the significant impact of mutations near post-translational modification sites,which further modulate chromatin dynamics and regulatory functions,offering insights into their role in oncogenesis and potential therapeutic targets.

关 键 词：Linker histone H1 EPIGENETICS histone cancer mutations chromatin structure NUCLEOSOME 

分 类 号：R730.2[医药卫生—肿瘤]