Despicable role of epithelial-mesenchymal transition in breast cancer metastasis:Exhibiting de novo restorative regimens  

作　　者：Paras Famta Saurabh Shah Biswajit Dey Kondasingh Charan Kumar Deepkumar Bagasariya Ganesh Vambhurkar Giriraj Pandey Anamika Sharma Dadi ASrinivasarao Rahul Kumar Santosh Kumar Guru Rajeev Singh Raghuvanshi Saurabh Srivastava 

机构地区：[1]Pharmaceutical Innovation and Translational Research Lab(PITRL),Department of Pharmaceutics,National Institute of Pharmaceutical Education and Research(NIPER),Hyderabad,Telangana,500037,India [2]Department of Biological Sciences,National Institute of Pharmaceutical Education and Research(NIPER),Hyderabad,500037,India [3]Central Drugs Standard Control Organization,Government of India,New Delhi,110002 India

出　　处：《Cancer Pathogenesis and Therapy》2025年第1期30-47,共18页癌症发生与治疗(英文)

摘　　要：Breast cancer(BC)is the most prevalent cancer in women globally.Anti-cancer advancements have enabled the killing of BC cells through various therapies;however,cancer relapse is still a major limitation and decreases patient survival and quality of life.Epithelial-to-mesenchymal transition(EMT)is responsible for tumor relapse in several cancers,This highly regulated event causes phenotypic,genetic,and epigenetic changes in the tumor microenvironment(TME).This review summarizes the recent advancements regarding EMT using dedifferentiation and partial EMT theories.We extensively review the mechanistic pathways,TME components,and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors.

关 键 词：BREASTCANCER Epithelial-to-mesenchymal transition METASTASES Cancer stem cells EPIGENETICS 

分 类 号：R737.9[医药卫生—肿瘤]