METALLOTHIONEIN

作品数：103被引量：263H指数：9
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相关机构：北京大学中山大学中国科学院植物研究所北京医科大学第一医院更多>>
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Biomarkers for tracking metabolic changes pre-post nutritional epigenetics diet/intervention to prevent autism and attention deficit/hyperactivity disorders in children
《World Journal of Experimental Medicine》2025年第2期12-23,共12页Renee J Dufault 
The prevalence of autism and attention deficit/hyperactivity disorders is increasing worldwide.Recent studies suggest the excessive intake of ultra-processed food plays a role in the inheritance of these disorders via...
关键词：Mercury Lead AUTISM Attention deficit/hyperactivity disorder METALLOTHIONEIN Nutritional epigenetics Zinc 
Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia
《Current Medical Science》2024年第4期799-808,共10页Tong-yuan LIU Xing FU Ying YANG Jia GU Min XIAO Deng-ju LI 
supported by the National Natural Science Foundation of China(No.82270177).
Objective The metabolic reprogramming of acute myeloid leukemia(AML)cells is a compensatory adaptation to meet energy requirements for rapid proliferation.This study aimed to examine the synergistic effects of glutami...
关键词：GLUTAMINE METFORMIN acute myeloid leukemia METALLOTHIONEIN 
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
《World Journal of Stem Cells》2024年第5期551-559,共9页Amani Yehya Joseph Azar Mohamad Al-Fares Helene Boeuf Wassim Abou-Kheir Dana Zeineddine Ola Hadadeh 
Supported by the National Council for Scientific Research in Lebanon,CNRS-L.
BACKGROUND Embryonic stem cells(ESCs)serve as a crucial ex vivo model,representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos.ESCs exhibit a unique combination of self-renewal potency,...
关键词：Mouse embryonic stem cells SELF-RENEWAL Apoptosis Cardiac differentiation B-cell lymphoma 2 PIM-2 Metallothionein-1 
Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery
《Biomedical and Environmental Sciences》2024年第1期117-121,共5页WEN Si Hui LI Lu Bei HUANG Hui Dan XIE Ying LUO Lei 
supported by the National Natural Science Foundation of China[grant numbers 82103887];Hunan Provincial Natural Science Foundation of China[grant numbers 2021JJ30752 and 2021JJ40374];National Science Fund for Excellent Young Scholars of Hunan Province[grant numbers 2023JJ20032];Changsha Natural Science[grant numbers 45045]。
The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various ca...
关键词：RENAL KIDNEY CADMIUM 
Molecular toxicity and defense mechanisms induced by silver nanoparticles in Drosophila melanogaster
《Journal of Environmental Sciences》2023年第3期616-629,共14页Zhidi Wang Liying Zhang Xing Wang 
supported by the Natural Science Foundation of Beijing, China (No. 5212012);the National Natural Science Foundation of China (No. 31801190);the 2115 Talent Development Program of China Agricultural University。
The widely use of silver nanoparticles(AgNPs) as antimicrobial agents gives rise to potential environmental risks. AgNPs exposure have been reported to cause toxicity in animals.Nevertheless, the known mechanisms of A...
关键词：Drosophila melanogaster Silver nanoparticles(AgNPs) Reactive oxygen species(ROS) DNA damage RNA-SEQ METALLOTHIONEIN 
Identification of cadmium containing metabolites in HepG2 cells after treatment with cadmium-selenium quantum dots
《Chinese Chemical Letters》2023年第1期564-568,共5页Beibei Chen Lu Peng Man He Chuan Wang Bin Hu 
The financial support from the National Natural Science Foundation of China(Nos.21575107,21775113,21575108);the Science Fund for Creative Research Groups of NSFC(No.20921062);the Fundamental Research Funds for the Central Universities(No.114009)。
The transformation of quantum dots(QDs)by organisms has attracted broad attention but remains unclear.Understanding of the metabolites helps to reveal the transformation pathway of QDs.Cd containingmetallothionein(MT)...
关键词：CdSe/ZnS quantum dots Cd speciation METALLOTHIONEIN Cells High performance liquid chromatography Inductively coupled plasma mass spectrometry Electrospray ionization mass spectrometry 
CD4 cell activation with the CD8 marker and metallothionein expression in the gills of cadmium-exposed mosquito fish(Gambusia affinis Baird and Girard 1853)juveniles
《Emerging Contaminants》2022年第1期280-287,共8页Moh Awaludin Adam Agoes Soegianto Carolyn Melissa Payus Ach Khumaidi Ramli Ramli Ernawati Ernawati Irawati Mei Widiastuti Era Insivitawati Yenny Risjani 
Ministry Education and Culture,Directorate of Research and Technology for Research and Innovation,grant number 028/AMD-SP2H/LT-MULTI-PDPK/LL7/2021.
This experiment aimed to determine how Cd exposure impacts CD4 cell activation,macrophage cells,pinocytosis activity,metallothionine expression,and Cd levels in juvenile Gambusia affinis gills.Four treatment groups we...
关键词：CADMIUM CD4 cell Fish health Immunity METALLOTHIONEIN Water pollution 
Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury被引量：2
《Neural Regeneration Research》2022年第3期577-586,共10页Wei Tang Zong-Duo Guo Wei-Na Chai Dong-Lin Du Xiao-Min Yang Lang Cao Hong Chen Chao Zhou Chong-Jie Cheng Xiao-Chuan Sun Zhi-Jian Huang Jian-Jun Zhong 
supported by the National Natural Science Foundation of China,Nos.82071397 (to XCS),82071332 (to ZDG);the Youth Fund of the National Natural Science Foundation of China,No.81801230 (to JJZ);the Excellent Scientific Research Talents Fund of the First Affiliated Hospital of Chongqing Medical University,China (to JJZ)。
Micro RNA-491-5 p(miR-491-5 p) plays an important role in regulating cell proliferation and migration;however,the effect of miR-491-5 p on neovascularization after traumatic brain injury remains poorly understood.In t...
关键词：brain injury cell migration cell proliferation endothelial cell hypoxia-inducible factor-1 alpha metallothionein 2 microRNA NEOVASCULARIZATION neurons vascular endothelial growth factor 
Zinc as a countermeasure for cadmium toxicity被引量：4
《Acta Pharmacologica Sinica》2021年第3期340-346,共7页Hai-tao Yu Juan Zhen Ji-yan Leng Lu Cai Hong-lei Ji Bradley B.Keller 
supported in part by the Kosair Charities Pediatric Heart Research Fund to B.B.K.,the US-China Pediatric Research Exchange Training Program to L.C.and B.B.K.,the First Hospital of Jilin University Youth Fund(JDYY92018031)to J Z;the Scientific and Technological Development Program of Jilin Province(20190701067GH)to J.Y.L;the Jilin Province Department of Finance Fund(2018SCZWSZX-005)to J.Y.L.;the National Natural Science Foundation of China(81974027)to H.LJ.All personnel expenses and partial research-related expenses for J2.and H.T.Y.were provided by Jilin University through a collaborative research agreement between the University of Louisville and Jilin University,Changchun,China.
Cadmium(Cd)is an important environmental pollutant and long-term Cd exposure is closely related to autoimmune diseases,cancer,cardiovascular diseases(CVD),and hepatic dysfunction.Zinc(Zn)is an essential metal that pla...
关键词：CADMIUM METALLOTHIONEIN ZINC Zinc transporters 
Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule
《Research》2021年第1期620-630,共11页Guodong Yuan Felipe Curtolo Yibing Deng Tao Wu Fang Tian Qun Ma Yutong Liu Jinglin Zuo Guilherme Menegon Arantes Peng Zheng 
was funded by the Fundamental Research Funds for the Central Universities(Grant No.14380259);the Natural Science Foundation of Jiangsu Province(Nos.BK20200058 and BK20202004);the National Natural Science Foundation of China(Grant Nos.21771103 and 21977047);the Fundação para Amparo a Pesquisa do Estado de São Paulo(FAPESP)(scholarship 2017/26109-0 to FC and Grants 2018/08311-9 and 2019/21856-7 to GMA)。
Human metallothionein(MT)is a small-size yet efficient metal-binding protein,playing an essential role in metal homeostasis and heavy metal detoxification.MT contains two domains,each forming a polynuclear metal clust...
关键词：structure CLUSTER BONDS 
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