云南高校图书馆联盟文献共享服务平台- HYPERMETHYLATION

HYPERMETHYLATION: 作品数：71被引量：390H指数：11; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：陈华武淑兰邓兆群张铭周静东更多>>; 相关机构：上海交通大学医学院附属瑞金医院北京大学第一医院复旦大学附属肿瘤医院东北师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Use of DNA methylation patterns for early detection and management of lung cancer:Are we there yet?: 《Oncology Research》2025年第4期781-793,共13页MILICA KONTIC FILIP MARKOVIC; Detecting lung cancer early is crucial for improving survival rates,yet it remains a significant challenge due to many cases being diagnosed at advanced stages.This review aims to provide advances in epigenetics which...; 关键词：Lung cancer DNA methylation EPIGENETICS HYPERMETHYLATION Early detection

SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia: 《Genes & Diseases》2025年第2期72-75,共4页Akhilesh Kaushal Samrat Roy Choudhury; supported by grants from the National Institutes of Health (No.P20GM121293)to S.R.C.;funded by the Seeds of Science Award and startup from the University of Arkansas for Medical Sciences (UAMS) and Arkansas Children's Research Institute (ACRI)to S.R.C.; The SET-NUP214 gene fusion is mainly found in patients primarily diagnosed with T-cell acute lymphoblastic leukemia(T-ALL)and rarely in acute myeloid leukemia(AML).1 Patients with the SET-NUP214 fusion protein(referre...; 关键词：acute LEUKEMIA cluster

DNA hypermethylation of COL4A1 in ultraviolet-Binduced age-related cataract models in vitro and in vivo: 《International Journal of Ophthalmology(English edition)》2024年第10期1791-1799,共9页Li Wang Dan Zhu Yang Yang Yuan He Jing Sun Yi-Ming Li Zi-Jing Wang Peng Li; Supported by the Shaanxi Provincial Department of Science and Technology Agency Project(No.2022SF-502);Xi’an Medical University Scientific Research Capacity Improvement Project(No.2022NLTS104);The Fifth Batch of Key Disciplines of Xi’an Medical University(No.medical technology12202306);Yunzhen Optometry Special Fund(No.2021HXZR10);Innovation and Entrepreneurship Training Program for College Students(No.S202211840043).; AIM:To explore the DNA methylation of COL4A1 in ultraviolet-B(UVB)-induced age-related cataract(ARC)models in vitro and in vivo.METHODS:Human lens epithelium B3(HLEB3)cells and Sprague Dawley rats were exposure to UVB...; 关键词：human lens epithelium cells age-related cataract COL4A1 HYPERMETHYLATION ULTRAVIOLET-B RAT

Hypermethylation of GSTM5 and its effect on oxidation in myelodysplastic syndrome: 《iLABMED》2024年第2期108-124,共17页Chi Wang Yafei Yu Qing Chang Tengteng Dong Liye Wang Mianyang Li; National Natural Science Foundation of China,Grant/Award Number:61971443。; Background:Hypermethylation of glutathione-S-transferase 5(GSTM5)and its effect on oxidation in the pathogenesis of myelodysplastic syndrome(MDS)were investigated.Methods:GSTM5 methylation was detected in bone marrow(...; 关键词：GLUTATHIONE GSTM5 METHYLATION myelodysplastic syndrome PROGNOSIS

TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes: 《International Journal of Ophthalmology(English edition)》2024年第3期537-544,共8页Yu Qian Ying Xiao Qiu-Rong Lin Zhao-Yu Xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-Ran Qin Hai-Dong Zou Chen-Hao Yang Pei-Yao Jin; Supported by the National Key Research and Development Program of China(No.2016YFC0904800);National Natural Science Foundation of China(No.82101181);China Scholarship Council(No.201506230096);Shanghai Sailing Program(No.19YF1439700).; ●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A to...; 关键词：DNA methylation 850K array PYROSEQUENCING diabetic retinopathy type 1 diabetes CHILDREN

Hypermethylation of the ALOX12 and CBS promoters in osteoporosis:Potential biomarkers for early diagnosis: 《Genes & Diseases》2024年第1期30-33,共4页Shang Guo Yue Wu Weekai Chia Peichun Hsu Hongwei Wang Yunliang Wang Biao Zhong; supported by grants from the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2019QNA23).; As a bone-confined chronic degenerative disorder,the progression of osteoporosis is characterized by abnormal crosstalk between osteoblasts and osteoclasts,leading to an imbalance of bone remodeling in adults.1 Severa...; 关键词：OSTEOPOROSIS DIAGNOSIS REMODELING

CG hypermethylation of the bHLH39 promoter regulates its expression and Fe deficiency responses in tomato roots: 《Horticulture Research》2023年第7期125-137,共13页Huihui Zhu Guanghao Han Jiayi Wang Jiming Xu Yiguo Hong Li Huang Shaojian Zheng Jianli Yang Weiwei Chen; This work was supported financially by the Natural Science Foundation of Zhejiang Province(LZ22C150001);the China Postdoctoral Science Foundation(2019 M652064).; Iron(Fe)is an essential micronutrient for all organisms,including plants,whose limited bioavailability restricts plant growth,yield,and nutritional quality.While the transcriptional regulation of plant responses to Fe...; 关键词：ROOTS HOMEOSTASIS treatment

Hypermethylation of thymosinβ4 predicts a poor prognosis for patients with acute-on-chronic hepatitis B liver failure: 《Hepatobiliary & Pancreatic Diseases International》2023年第4期373-382,共10页He Wang Yan-Ping Yin Zhen-Li Wang Yu Qian Yu-Chen Fan Hui-Hui Liu Kai Wang; supported by grants from the Key Project of the Chinese Ministry of Science and Technology(2017ZX102022022);the National Natural Science Foundation of China(81970522);the Key Research and Development Project of Shandong Province(2019GSF108023).; Background:It has been demonstrated that thymosinβ4(Tβ4)could inflect the severity of acute-on-chronic hepatitis B liver failure(ACHBLF),but the relationship between its methylation status and the prognosis of liver...; 关键词：Acute-on-chronic hepatitis B liver failure Acute-on-chronic hepatitis B pre-liver failure Thymosinβ4 METHYLATION PROGNOSIS

Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging被引量：2: 《National Science Review》2023年第6期60-63,共4页Fu-Hui Xiao Hao-Tian Wang Xiao-Qiong Chen Ming-Xia Ge Dongjing Yan Xing-Li Yang Li-Qin Yang Rong Lin Rong-Hui Guo Wen Zhang Nelson Leung-Sang Tang Yonghan He Jumin Zhou Wang-Wei Cai Qing-Peng Kong; supported jointly and equally by grants from the National Key R&D Program of China(2018YFE0203700 and 2018YFC2000400);the National Natural Science Foundation of China(91749109 and 82071595);Chinese Academy of Sciences Project for Young Scientists in Basic Research(YSBR-076);the Key Research Program(KFZD-SW-221);the Key Research Program of Frontiers Science(QYZDB-SSW-SMC020);the Yunnan Fundamental Research Project(202201AS070080);the High-level Talent Promotion and Training Project of Kunming(Spring City Plan;2020SCP001);the Yunling Scholar of Yunnan Province;the CAS‘Light of West China’Program(to F.-H.X.);the Reserve Talent Project of Young and Middle-aged Academic and Technical Leaders in Yunnan Province(202305AC160029); Centenarians,as excellent examples of extreme yet successful aging,not only display a much longer lifespan but can also delay or even escape major agerelated diseases,such as cardiovascular disorders,neurodegenerative...; 关键词：DISEASES AGING CARDIOVASCULAR

Revolutionizing Non-Invasive Biomarker Discoveries: The Power of Methylation Screening Analysis in Cell-Free DNA Liquid Biopsy: 《Open Journal of Genetics》2023年第1期48-74,共27页Min Seob Lee Na Young Min Hyuk Jung Kwon Yonjung Kim Isaac Kise Lee; Epigenetic changes of DNA, including methylation, have long been recognized as key indicators of various diseases, including aging, cancer, and neurological disorders. Biomarker discoveries based on distinct methylati...; 关键词：Epigenetics Biomarkers Cell-Free DNA (cf-DNA) METHYLATION Liquid Biopsy Drug Target Methylation-Specific Restriction Enzyme (MSRE) Cancer Epigenetic Drugs HYPERMETHYLATION HYPOMETHYLATION

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