Hypermethylation of the ALOX12 and CBS promoters in osteoporosis:Potential biomarkers for early diagnosis  

作　　者：Shang Guo Yue Wu Weekai Chia Peichun Hsu Hongwei Wang Yunliang Wang Biao Zhong 

机构地区：[1]Department of Orthopedic Surgery,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200023,China [2]Institute of Translational Medicine,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine(SJTU-SM),Shanghai 200025,China [3]The University of Chicago,Department of Medicine,Chicago,IL 60637,USA [4]Department of Neurology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014,China

出　　处：《Genes & Diseases》2024年第1期30-33,共4页基因与疾病（英文）

基　　金：supported by grants from the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2019QNA23).

摘　　要：As a bone-confined chronic degenerative disorder,the progression of osteoporosis is characterized by abnormal crosstalk between osteoblasts and osteoclasts,leading to an imbalance of bone remodeling in adults.1 Several studies reported that arachidonic acid ester 12 lipoxygenase(ALOX12)acts as a regulator in bone genesis by participating in the activation of the peroxisome proliferatoractivated receptor(PPARG)pathway through its reaction product.

关 键 词：OSTEOPOROSIS DIAGNOSIS REMODELING 

分 类 号：R68[医药卫生—骨科学]