REMODELING

作品数：492被引量：1436H指数：17
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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex
《Neural Regeneration Research》2025年第10期2923-2937,共15页Yan Li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li 
supported by the National Natural Science Foundation of China,Nos.82272171(to ZY),82271403(to XL),81941011(to XL),31971279(to ZY),31730030(to XL);the Natural Science Foundation of Beijing,No.7222004(to HD).
The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate ne...
关键词：adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation 
Moderate red wine alleviates high-fat diet-induced atherosclerosis in ApoE^(-/-)mice via modulations of liver metabolism through gut microbiota remodeling
《Food Science and Human Wellness》2025年第4期1411-1423,共13页Xuanxuan Chen Hong Yang Kaikai Li Jianhong Cao Xiaoyun Xu Siyi Pan Erhu Li 
the research funds from the National Natural Science Foundation of China(32272294)。
Red wine has a good potential for alleviating atherosclerosis,but the mechanisms related to hepatointestinal circulation remain to be elucidated.This study showed that administration of a high-polyphenol red wine(16 m...
关键词：WINE ATHEROSCLEROSIS Gut microbiota Untargeted metabolomics Short chain fatty acids 
Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury
《Neural Regeneration Research》2025年第6期1749-1763,共15页Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li 
supported by the National Natural Science Foundation of China,Nos.82030071 (to JH),82272495 (to YC);Science and Technology Major Project of Changsha,No.kh2103008 (to JH);Graduate Students’ Independent Innovative Projects of Hunan Province,No.CX20230311 (to YJ)。
Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-met...
关键词：corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury SYRINGIN TRIB2 
Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma
《Genes & Diseases》2025年第3期42-45,共4页Jie Li Yuyuan Zhang Jinhai Deng Siyuan Weng Hui Xu Yuhao Ba Anning Zuo Shutong Liu Quan Cheng Jian Zhang Peng Luo Zhen Li Xinwei Han Zaoqu Liu 
supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).
The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accum...
关键词：cep hepatocellular carcinoma hepatocellular carcinoma hcc lactate metabolism IMMUNITY proliferation infiltration immunosuppressive cells remodeling immune microenvironment immunosuppressive microenvironment 
The role of axon guidance molecules in the pathogenesis of epilepsy
《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang 
supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...
关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling 
Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats
《Neural Regeneration Research》2025年第5期1495-1504,共10页Yunting Xiang Xiangxin Xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu 
supported by the National Natural Science Foundation of China,Nos.81871836(to MZ),82172554(to XH),and 81802249(to XH),81902301(to JW);the National Key R&D Program of China,Nos.2018YFC2001600(to JX)and 2018YFC2001604(to JX);Shanghai Rising Star Program,No.19QA1409000(to MZ);Shanghai Municipal Commission of Health and Family Planning,No.2018YQ02(to MZ);Shanghai Youth Top Talent Development Plan;Shanghai“Rising Stars of Medical Talent”Youth Development Program,No.RY411.19.01.10(to XH)。
Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network lev...
关键词：brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity 
A novel nested gene Aff3ir participates in vascular remodeling by enhancing endothelial cell differentiation in mice
《Genes & Diseases》2025年第2期106-109,共4页Yue Zhao Mazdak Ehteramyan Yi Li Xuefeng Bai Lei Huangg Yingtang Gao Angshumonik Angbohangg Xiaoping Yang Steven Lynham Andriana Margariti Ajay M.Shah Yaling Tao Ting Cai Tong Li Min Zhang Lingfang Zeng 
supported by a British Heart Foundation PhD studentshipFS-15-74-31669 (to L.Z.);projectgrantPG/22/11055 (to M.Z.);partially supported by the China Scholarship Council。
Gene overlap serves as a common strategy employed by bacteria and viruses to expand their genomic capacity.Over the past two decades,advances in omics studies have unveiled a prevalence of overlapped genes in eukaryot...
关键词：CARDIOVASCULAR REMODELING PREVALENCE 
Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice
《Genes & Diseases》2025年第2期288-303,共16页Qi Li Xiaoyan Qin Liangxu Wang Dingheng Hu Rui Liao Huarong Yu Zhongjun Wu Yanyao Liu 
funded by the National Natural Science Foundation of China (No.82300745 to Yanyao Liu);China Postdoctoral Science Foundation (No.2023M730442 to Yanyao Liu);Chongqing Postdoctoral Science Foundation of China (No.CSTB2023NSCQ-BHX1003 to Yanyao Liu);Postdoctoral Cultivation Project of the First Affiliated Hospital of Chongqing Medical University (No.CYYY-BSHPYXM-202301 to Yanyao Liu);Chongqing Postdoctoral Innovation Talents Support Program (Chongqing,China) (No.2309013437264551 to Yanyao Liu)。
Hepatic ischemia-reperfusion injury is an unavoidable surgical complication of liver transplantation and the leading cause of poor graft function and increased mortality post-transplantation.Multiple mechanisms have b...
关键词：INFLAMMATION Liver ischemia-reperfusion injury Metabolic remodeling Metabolomics TRANSCRIPTOMICS 
Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling
《Food Science and Human Wellness》2025年第2期769-781,共13页Yongyong Liu Kai Huang Xiao Guan Sen Li Hongdong Song Ying Zhang Yu Zhang Zhu Sun Zhiquan Yu 
financially supported by the Major Project of Inner Mongolia Science and Technology Department,China(2021ZD0002);National Natural Science Foundation of China,China(32202054);Project Supported by the Shanghai Committee of Science and Technology,China(20DZ2202700)。
Oat avenanthramides(AVNs)have been found to exhibit novel lipid-lowering effects.However,the mechanism remains unclear.In this study,the effect of avenanthramide B(AVN B),as one of the major AVNs,on highfat diet(HFD)-...
关键词：Avenanthramide B High-fat diet Fatty acid metabolism Ileal lipid absorption Gut bacteria and fungi 
Golgi Protein 73 Promotes Angiogenesis in Hepatocellular Carcinoma
《Research》2025年第1期739-751,共13页Yiming Liu Xinyang Hu Sining Zhou Ting Sun Feiyan Shen Linghui Zeng 
supported by the National Natural Science Foundation of China under grant 82103397 to Y.L.;R&D Program of Zhejiang Province under grant 2024C03142 to L.Z.
Golgi protein 73(GP73),a resident protein of the Golgi apparatus,is notably elevated in hepatocellular carcinoma(HCC).While its critical role in remodeling the tumor microenvironment(TME)is recognized,the intricate me...
关键词：golgi apparatusis remodeling tumor microenvironment tme ANGIOGENESIS hepatocellular carcinoma prolyl hydroxylase golgi protein 
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