Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling  

作　　者：Yongyong Liu Kai Huang Xiao Guan Sen Li Hongdong Song Ying Zhang Yu Zhang Zhu Sun Zhiquan Yu 

机构地区：[1]School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China [2]National Grain Industry(Urban Grain and Oil Security)Technology Innovation Center,Shanghai 200093,China [3]Inner Mongolia Yangufang Whole Grain Industry Development Co.,Ltd.,Hohhot 011799,China

出　　处：《Food Science and Human Wellness》2025年第2期769-781,共13页食品科学与人类健康(英文)

基　　金：financially supported by the Major Project of Inner Mongolia Science and Technology Department,China(2021ZD0002);National Natural Science Foundation of China,China(32202054);Project Supported by the Shanghai Committee of Science and Technology,China(20DZ2202700)。

摘　　要：Oat avenanthramides(AVNs)have been found to exhibit novel lipid-lowering effects.However,the mechanism remains unclear.In this study,the effect of avenanthramide B(AVN B),as one of the major AVNs,on highfat diet(HFD)-induced mice was investigated.Results showed that AVN B significantly inhibited weight gain and improved hepatic and serum lipid biochemical indices.Hepatic RNA-sequencing analysis suggested that AVN B significantly modulates fatty acid(FA)metabolism.Hepatic real-time qualitative polymerase chain reaction(RT-q PCR)and Western blot results indicated that AVN B could alleviate FA synthesis by activating the adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)-sterol regulatory element binding protein-1c(SREBP1c)-fatty acid synthase(FAS),and increase FA oxidation by activating the AMPK/carnitine palmitoyltransferase 1A(CPT1A)and peroxisome proliferator-activated receptorα(PPARα).Additionally,AVN B had a regulating effect on ileum lipid metabolism by inhibiting intestinal cell differentiation and downregulating the expression levels of FA absorption-related protein and gene.Moreover,AVN B promoted the growth of beneficial bacteria and fungi such as Coriobacteriaceae_UCG-002,Parvibacter,Enterococcus,and Aspergillus,while decreasing the abundance of Roseburia,unclassified_f_Lachnospiraceae,Cladosporium,Eurotium,unclassified_f_Aspergillaceae and unclassified_f_Ceratocystidaceae.All these results provided new points of the lipid-lowing mechanism of AVNs and oats via the gut-liver axis.

关 键 词：Avenanthramide B High-fat diet Fatty acid metabolism Ileal lipid absorption Gut bacteria and fungi 

分 类 号：R73[医药卫生—肿瘤]