The role of axon guidance molecules in the pathogenesis of epilepsy  

作　　者：Zheng Liu Chunhua Pan Hao Huang 

机构地区：[1]Department of Neurology,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou Province,China

出　　处：《Neural Regeneration Research》2025年第5期1244-1257,共14页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。

摘　　要：Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with the pathogenicity of axon guidance molecules in

关 键 词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling 

分 类 号：R742.1[医药卫生—神经病学与精神病学]