Moderate red wine alleviates high-fat diet-induced atherosclerosis in ApoE^(-/-)mice via modulations of liver metabolism through gut microbiota remodeling  

作　　者：Xuanxuan Chen Hong Yang Kaikai Li Jianhong Cao Xiaoyun Xu Siyi Pan Erhu Li 

机构地区：[1]College of Food Science and Technology,Huazhong Agricultural University,Wuhan 430070,China [2]Key Laboratory of Environment Correlative Dietology,Ministry of Education,Huazhong Agricultural University,Wuhan 430070,China [3]Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control,Huazhong Agricultural University,Wuhan 430070,China [4]Shangri-La Winery Co.,Ltd.,Diqing 674412,China

出　　处：《Food Science and Human Wellness》2025年第4期1411-1423,共13页食品科学与人类健康(英文)

基　　金：the research funds from the National Natural Science Foundation of China(32272294)。

摘　　要：Red wine has a good potential for alleviating atherosclerosis,but the mechanisms related to hepatointestinal circulation remain to be elucidated.This study showed that administration of a high-polyphenol red wine(16 mL/(kg·day))for 16 weeks significantly reduced the atherosclerotic lesion in high-fat diet-fed ApoE^(-/-)mice.The total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels of plasma were lowered by 11.54%and 18.98%.The pro-inflammatory cytokines including interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)levels were decreased by 27.59%and 31.92%.Red wine also reduced triglyceride(TG)level and lipid deposition in the liver,and increased the concentration of total bile acids(TBA).Untargeted metabolomics analysis indicated that red wine modulated the disorder of liver metabolism by regulating sphingolipid signaling pathway,sphingolipid metabolism,glycerophosphlipid metabolism,choline metabolism and bile secretion.16S rRNA sequencing revealed that red wine increased the abundance of Akkermansia and Bifidobacterium and reduced the abundance of Mucispirillum,Romboutsia,Lactobacillus,Bilophila and Blautia,along with the increased concentrations of short-chain fatty acids(SCFAs)in feces.These findings indicated that red wine could exert anti-atherosclerotic effect by regulating gut microbiota,restoring SCFAs,alleviating liver metabolic disorders.

关 键 词：WINE ATHEROSCLEROSIS Gut microbiota Untargeted metabolomics Short chain fatty acids 

分 类 号：TS201.4[轻工技术与工程—食品科学] R543.5[轻工技术与工程—食品科学与工程]