HYPOMETHYLATION

作品数：25被引量：85H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：邵宗鸿任悦付蓉张伟李新新更多>>
相关机构：天津医科大学总医院广东省人民医院(广东省医学科学院)上海交通大学江苏省肿瘤医院更多>>
相关期刊：《World Journal of Clinical Oncology》《Cancer Communications》《世界最新医学信息文摘》《癌变．畸变．突变》更多>>
相关基金：国家自然科学基金国家科技支撑计划广东省自然科学基金宁波市自然科学基金更多>>
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Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2024年第1期35-42,共8页Li-Li Miao Jing-Wen Wang Hui-Hui Liu Shuai Gao Yu-Chen Fan Kai Wang 
This study was supported by grants from the Key Project of the Chinese Ministry of Science and Technology(2017ZX102022022);National Key Research and Development Program of China(2021YFC2301801).
Background: Glycine dehydrogenase(GLDC) plays an important role in the initiation and proliferation of several human cancers. In this study, we aimed to detect the methylation status of GLDC promoter and its diagnosti...
关键词：Hepatocellular carcinoma Glycine dehydrogenase DNA methylation Peripheral blood mononuclear cells 
Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer被引量：3
《Journal of Genetics and Genomics》2023年第8期573-581,共9页Rong Qiao Feifei Di Jun Wang Yujie Wei Tian Xu Liping Dai Wanjian Gu Baohui Han Rongxi Yang 
supported by the Nanjing Social Supporting Department and Social Supporting Ministry of Jiangsu Province granted from 2018 to 2020,and the Nanjing TANTICA Co.Ltd(grant no.2018LC01.1).
Early detection of lung cancer (LC) is vital for reducing LC-related mortality. However, noninvasive diagnostic tools remain a great challenge. We aim to identify blood-based biomarkers for the early detection of LC. ...
关键词：Lung cancer Early detection DNA methylation FUT7 Mass spectrometry 
Revolutionizing Non-Invasive Biomarker Discoveries: The Power of Methylation Screening Analysis in Cell-Free DNA Liquid Biopsy
《Open Journal of Genetics》2023年第1期48-74,共27页Min Seob Lee Na Young Min Hyuk Jung Kwon Yonjung Kim Isaac Kise Lee 
Epigenetic changes of DNA, including methylation, have long been recognized as key indicators of various diseases, including aging, cancer, and neurological disorders. Biomarker discoveries based on distinct methylati...
关键词：Epigenetics Biomarkers Cell-Free DNA (cf-DNA) METHYLATION Liquid Biopsy Drug Target Methylation-Specific Restriction Enzyme (MSRE) Cancer Epigenetic Drugs HYPERMETHYLATION HYPOMETHYLATION 
Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis被引量：2
《Current Medical Science》2022年第6期1248-1255,共8页Ru-ting XIE Qian-yu LI Xue-chen SUN Qing-jun ZHI Xiang-xiang HUANG Xing-chen ZHU Qi-zeng MIAO Dai-zhan ZHOU Dong-yan HAN 
Objective Thyroid hormones(THs)regulate multiple physiological activities in the liver,including cellular metabolism,differentiation,and cell growth,and play important roles in the pathogenesis of hepatocellular carci...
关键词：thyroid hormones thyroid peroxidase hepatocellular carcinoma METHYLATION tumor thrombosis 
LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients被引量：7
《Cancer Biology & Medicine》2021年第3期675-692,共18页Haihua Tian Jinchang Pan Shuai Fang Chengwei Zhou Hui Tian Jinxian He Weiyu Shen Xiaodan Meng Xiaofeng Jin Zhaohui Gong 
supported in part by research grants from the Non-profit Technology Research Program of Zhejiang(Grant No.LGF18H160006);the Natural Science Foundation of Zhejiang(Grant No.LQ18H200001);the Non-profit Technology Research Program of Ningbo(Grant No.2019C50040);the Natural Science Foundation of Ningbo(Grant No.2018A610204);the Major Project for Science and Technology Innovation 2025 of Ningbo(Grant No.2019B10037);the K.C.Wong Magna Fund at Ningbo University。
Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PC...
关键词：Antisense long noncoding RNA DPP10-AS1 HYPOMETHYLATION malignant process lung cancer 
Alteration of oncogenic IGF-II gene methylation status associates with hepatocyte malignant transformation被引量：6
《Hepatobiliary & Pancreatic Diseases International》2019年第2期158-163,共6页Bo-Jun Tai Min Yao Wen-Jie Zheng Yu-Cheng Shen Li Wang Jian-Ying Sun Meng-Na Wu Zhi-Zhen Dong Deng-Fu Yao 
supported partly by grants from the National Natural Science Foundation(81673241,81702419,81872738,81873915);the Jiangsu Medical Science(BE2016698)&Graduate Innovation(KYCX17_1934);the International S.&T.Coopera-tion Program(2013DFA32150)of China
Background: Oncogenic insulin-like growth factor-II(IGF-II) is overexpressed in hepatocellular carcinoma(HCC). The present study aimed to analyze the dynamic alteration of IGF-II CpG site methylation status and its mo...
关键词：Hepatocellular carcinoma INSULIN-LIKE growth factor-Ⅱ HYPOMETHYLATION Methylation-specific PCR Promoter Molecular mechanism 
Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis被引量：8
《Cancer Communications》2019年第1期482-498,共17页Fei Shao Xueying Yang Wei Wang Juhong Wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue Shugeng Gao Yibo Gao Zhimin Lu Jie He 
This study was funded by The National Key R&D Program of China(2017YFC1308702,2017YFC1311000,2018YFC1312100);the Beijing Municipal Science&Technology Commission(Z181100006218032,Z181100001918002);the CAMS Initiative for Innovative Medicine(2017-I2M-1-005,2017-I2M-2-003,2019-I2M-2-002);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2017PT32001,2017PT32017).
Background:Cancer cells reprogram metabolism for proliferation.Phosphoglycerate kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial metabolism.However,the...
关键词：PGK1 Cancer metabolism Epigenetics PHOSPHORYLATION Methylation The Cancer Genome Atlas Pan-cancer analysis PROGNOSIS Overall survival 
Hypoxia induces hypomethylation of the HMGB1 promoter via the MAPK/DNMT1/ HMGB1 pathway in cardiac progenitor cells
《Acta Biochimica et Biophysica Sinica》2018年第11期1121-1130,共10页Jinwen Su Ming Fang Bei Tian Jun Luo Can Jin Xuejun Wang Zhongping Ning Xinming Li 
the grants from the Shanghai Pudong New Area Health Planning Commission Industry Special Project (No.PW2013E-2);the Shanghai Municipal Health Planning Commission Key Specialist Project (No.ZK2015A13);the Shanghai Pudong New Area Science Committee Project (No.PKJ2017-Y42);the National Natural Science Foundation of China (No. 81560077).
Apoptosis is involved in the death of cardiac progenitor cells (CPCs)after myocardial infarction (MI) in the heart.The loss of CPCs results in infarct scar and further deterioration of the heart function. Though stem ...
关键词：CPCs HYPOXIA HMGB1 DNMT1 MAPKS 
Dietary betaine activates hepatic VTGⅡexpression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression被引量：3
《Journal of Animal Science and Biotechnology》2018年第2期381-390,共10页Nagmeldin A.Omer Yun Hu Yan Hu Abdulrahman A.Idriss Halima Abobaker Zhen Hou Haibo Dong Ruqian Zhao 
supported by the National Natural Science Foundation of China(31672512);Special Fund for Agro-scientific Research in the Public Interest(201003011);the Fundamental Research Funds for the Central Universities(KYZ201212);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
Background: Vitellogenin(VTG) is a precursor of egg yolk proteins synthesized within the liver of oviparous vertebrates. Betaine is an important methyl donor that is reported to improve egg production of laying hens w...
关键词：BETAINE Glucocorticoid receptor HYPOMETHYLATION Laying HENS VITELLOGENIN 
Decreased invasion ability of hypotaurine synthesis deficient glioma cells was partially due to hypomethylation of Wnt5a promoter被引量：1
《BIOCELL》2017年第1期27-32,共6页Hong TIAN Peiyu CONG Ruiqun QI Xinghua GAO Xin LIU Hongsheng LIU Fengping SHAN 
supported by New and Old Energy Conversion Project of Jining City(2017ZDGH031);Guiding funds for the development of local science and technology by the Central government(2017106014);Natural Science Foundation of Liaoning Province(L2015317).
Glioma is one of the lethal central nervous system tumors.The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues,resulting in inevitable recurrenc...
关键词：Glioma WNT5A HYPOTAURINE Tumor invasiveness 
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