云南高校图书馆联盟文献共享服务平台- ESCIN

ESCIN: 作品数：15被引量：35H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：傅丽英夏国瑾江明性姚伟星杨艳更多>>; 相关机构：华中科技大学泸州医学院中山大学附属第三医院北京大学更多>>; 相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《药学学报》更多>>; 相关基金：国家自然科学基金更多>>

Synthetic Investigation toward Acyl Group-Free Escin Derivatives: 《Chinese Journal of Chemistry》2024年第24期3263-3268,共6页Xin Lv Jin-Xi Liao Zhen-Qiang Li Zhi-Sheng Xiong Qi-Shuang Yin Hui Liu Yuan-Hong Tu Jian-Song Sun; supported by the National Natural Science Foundation of China(22177042 and 22307048);The generous support from Beijing Municipal Commission of Science and Technology(L212015)was also highly appreciated.; With protoescigenin as starting material and through orchestrated application of Yu and Schmidt glycosylation protocols,the synthesis of acyl group-free escin derivatives was achieved for the first time.As the undesir...; 关键词：ESCIN Triterpenoid saponin Synthesis Yu glycosylation Schmidt glycosylation Carbohydrates Gold Hydrogen bonds

Progress in anti-inflammatory effects of escin: 《中国药理学与毒理学杂志》2021年第10期721-722,共2页FU Feng-hua WANG Tian; The fraction of horse chestnut seeds was named escins,which mainly consists of A,B,C,and D escin.Accumulating evidence suggests that escin exerts potent anti-inflammatory and anti-edematous effects.The effects of esci...; 关键词：ESCIN INFLAMMATION EDEMA capillary permeability acute lung injury

Escin enhances anti-rheumatoid arthritis effects of low dose glucocorticoids through up-regulation of glucocorticoid receptor: 《中国药理学与毒理学杂志》2019年第9期749-750,共2页ZHANG Lei-ming HUANG Ya-nan DU Yuan WANG Mei-ling WANG Xin-lin WANG Yan-fang HAO Yan-fei WANG Tian FU Feng-hua; National Natural Science Foundation of China(81873039;81973547);Natural Science Foundation of Shandong Province(ZR2017MH068); OBJECTIVE To investigate the anti-rheumatoid arthritis(RA)effect of Escin combined with low dose of GCs(dexameth⁃asone,Dex)and its underlying mechanism.METHODS Adjuvant-induced rheumatoid arthritis rats and LPS-injure...; 关键词：rheumatoid arthritis GLUCOCORTICOIDS glucocorticoid receptor ESCIN DEXAMETHASONE

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/yH2AX pathway被引量：2: 《Acta Pharmacologica Sinica》2018年第10期1645-1660,共16页Zhong WANG Qiang CHEN Bin LI Jia-ming XIE Xiao-dong YANG Kui ZHAO Yong WU Zhen-yu YE Zheng-rong CHEN Zheng-hong QIN Chun-gen XING; Escin, a triterpene saponin isolated from horse chestnut seed, has been used to treat encephaledema, tissue swelling and chronic venous insufficiency. Recent studies show that escin induces cell cycle arrest, tumor pr...; 关键词：escin p62 DNA damage ATM/yH2AX pathway apoptosis colorectal cancer HCT116 cells HCT8 cells

Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor被引量：10: 《Chinese Journal of Natural Medicines》2018年第2期105-112,共8页ZHAO Shu-Qi XU Shi-Qiang CHENG Jing CAO Xiao-Lu ZHANG Ying ZHOU Wei-Ping HUANG Yan-Juan WANG Jun HU Xia-Min; supported by the National Natural Science Foundation of China(No.81602108); Escin, as an internally applied anti-inflammatory agent, has been widely used in the treatment of inflammation and edema resulting from trauma or operation in the clinic. However, the effect of its external use on cut...; 关键词：ESCIN Cutaneous inflammation GLUCOCORTICOID Nuclear factor-κB Activator protein-1

Laminin-5,Cassis,Escin(LCE)修复霜促进点阵激光术后皮肤修复的研究被引量：5: 《临床皮肤科杂志》2015年第11期688-691,共4页郑跃陈海燕叶聪秀易金玲朱雯萱谢小元赖维; 目的:研究Laminin-5,Cassis,Escin(LCE)修复霜对2 940 nm Er∶YAG点阵激光术后皮肤的修复作用。方法:试验采取随机双盲、半边脸自身对照的方法,2 940 nm Er:YAG点阵激光对15名受试者双侧眼角或眼周皱纹进行治疗。激光术后即刻及术后第1...; 关键词：层粘连蛋白-5短肽皮肤修复点阵激光

β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma被引量：5: 《World Journal of Gastroenterology》2015年第4期1148-1157,共10页Gui-Li Huang Dong-Yan Shen Cheng-Fu Cai Qiu-Yan Zhang Hong-Yue Ren Qing-Xi Chen; Supported by National Nature Science Foundation of China,No.81101502;the National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China,No.J1310027; AIM: To develop a safe and effective agent for cholangiocarcinoma(CCA) chemotherapy. METHODS: A drug combination experiment was conducted to determine the effects of β-escin in c o m b i n a t i o n w i t h c h e m o...; 关键词：β-escin Multi-drug resistance P-GLYCOPROTEIN GSK3Β

二性霉素B与β-escin混合穿孔电极液在人心房肌细胞SK2电流记录中的应用被引量：4: 《中国应用生理学杂志》2012年第3期214-218,I0002,共6页王华李涛雷明李妙龄丁银元杨艳曾晓荣; 国家自然科学基金资助项目(30870903); 目的:为研究钙离子对人心房肌细胞小电导钙激活钾通道电流(ISK2)的调节作用,建立用二性霉素B(amphotericin B)与β-escin穿孔的膜片钳(PPR)技术。方法:体外循环术中取得右心耳,应用急性酶分离获得单个人体心房肌细胞,用二性霉素B和/或β...; 关键词：β-escin 二性霉素B 人心房肌细胞小电导钙激活钾电流穿孔膜片钳技术

Escin may exert a synergistic anti-inflammatory effect with glucocorticoids: 《Health》2010年第2期79-81,共3页Lei-Ming Zhang Tian Wang Hua-Ying Fan Xin Yu Bing Han Mei Zhu Feng-Hua Fu; Escin is a natural mixture of triterpenoid as- ponin isolated from the seed of the horse chestnut and demonstrates anti-oedematous and anti-inflammatory effects. As yet, the pre-cise mechanisms by which escin exerts i...; 关键词：ESCIN GLUCOCORTICOIDS INFLAMMATION Synergism

Studies on Triterpenoid Saponins of Seeds of Aesculus chinensis Bunge var. chekiangensis (Hu et Fang) Fang被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2004年第2期87-91,共5页郭杰杨秀伟; NationalNaturalScienceFoundationofChina( 2 9972 0 0 4); Aim To study the saponin constituents of the seeds of Aesculus chinensis Bunge var. chekiangensis (Hu et Fang) Fang. Methods Compounds were separated and purified by macroreticular resin column chromatography and high...; 关键词：Aesculus chinensis Bunge var. chekiangensis TRITERPENOIDS ESCIN isoescin

ESCIN