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SUMOYLATION: 作品数：87被引量：165H指数：7; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：龚宇彭章龙张简尤圣武廖书胜更多>>; 相关机构：中南大学上海交通大学华东师范大学中国科学院大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>

Construction and validation of a novel SUMOylation-related IncRNAs signature for predicting the prognosis,tumor immune microenvironment,and therapeutic sensitivity of lung adenocarcinoma: 《Genes & Diseases》2025年第2期102-105,共4页Jie Cai Weizhong Ruan Zida Wang Gongzhe Liu Bei Yang Hao Wang Deping Zhao Chang Chen Xiaogang Zhao; supported by the Shanghai Sailing Program (China) (No.22YF1437600 to J.C.);the Programs of Shanghai Pulmonary Hospital (China) (No.fkzr2477 to J.C.).; Lung adenocarcinoma(LUAD)is the most prevalent subtype of lung cancer and the leading cause of cancer deaths worldwide.1 Despite immunotherapy,radiotherapy,and chemotherapy advances,treatment outcomes remain unsatisfa...; 关键词：ADENOCARCINOMA PROGNOSIS lung

Decoding post-translational modification for understanding stress tolerance in plant: 《Crop Design》2024年第4期9-20,共12页Anuradha Pandey Dipak Gayen; DG is gratefully acknowledging the SERB-DST grant(SRG/2020/001024),(CRG/2023/003167);Central University of Rajasthan research support;AP is gratefully acknowledging the Central University of Rajasthan for financial support。; Plants undergo deteriorating stress situations,which has an adverse effect on their overall growth,maturation,and development.To mitigate these situations plants undergo regulatory cellular mechanisms including epigen...; 关键词：Post-translational modification PHOSPHORYLATION UBIQUITINATION SUMOYLATION GLYCOSYLATION Biotic Abiotic stress Dehydration stress Salt stress Cold stress

A TT1–SCE1 module integrates ubiquitination and SUMOylation to regulate heat tolerance in rice: 《Molecular Plant》2024年第12期1899-1918,共20页Hong-Xiao Yu Ying-Jie Cao Yi-Bing Yang Jun-Xiang Shan Wang-Wei Ye Nai-Qian Dong Yi Kan Huai-Yu Zhao Zi-Qi Lu Shuang-Qin Guo Jie-Jie Lei Ben Liao Hong-Xuan Lin; National Natural Science Foundation of China(32388201);Biological Breeding-National Science and Technology Major Project(2023ZD04071);Laboratory of Lingnan Modern Agriculture Project(NT2021002);Chinese Academy of Sciences(159231KYSB20200008);CAS-Croucher Funding Scheme for Joint Laboratories and National Key Laboratory of Plant MolecularGenetics。; Heat stress poses a significant threat to grain yield.As anα2 subunit of the 26S proteasome,TT1 has been shown to act as a critical regulator of rice heat tolerance.However,the heat tolerance mechanisms mediated by T...; 关键词：RICE heat tolerance UBIQUITINATION SUMOYLATION heat-shock protein

IRF1-mediated upregulation of PARP12 promotes cartilage degradation by inhibiting PINK1/Parkin dependent mitophagy through ISG15 attenuating ubiquitylation and SUMOylation of MFN1/2: 《Bone Research》2024年第4期933-951,共19页Zengfa Deng Dianbo Long Changzhao Li Hailong Liu Wei Li Yanlin Zhong Xiaolin Mo Ruiyun Li Zibo Yang Yan Kang Guping Mao; supported by the National Natural Science Foundation of China (82202739);Guangdong Basic and Applied Basic Research Foundation Natural Science Fund Project-Youth Promotion Project (2024A1515030260);China Statefunded Postdoctoral Researchers Program (GZC20233265);National Natural Science Foundation of China (81972051)。; Osteoarthritis(OA)is an age-related cartilage-degenerating joint disease.Mitochondrial dysfunction has been reported to promote the development of OA.Poly(ADP-ribose)polymerase family member 12(PARP12)is a key regulat...; 关键词：PARP1 INHIBITING cartilage

Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway: 《Frigid Zone Medicine》2024年第4期202-211,共10页Nannan Tang Jiatong Li Zhuo Wang Jinlu Zuo Zifeng Zhang Di Huang Yannan Han Yuqing Chen Yilin Sun Xiang Li Ruxue Mu Qingxue Ma Jie Zhang Jiaying Wu He Wang Hongxia Zhao Xingli Dong Zhiguo Wang Yu Liu Dan Zhao Baofeng Yang; supported by the National Natural Science Foundation of China(82330011,U21A20339);the CAMS Innovation Fund for Medical Sciences(CIFMS,2020-I2M-5-003);the National Natural Science Foundation of China(No.82370302,31871175);Natural Science Foundation of Heilongjiang Province of China(No.YQ2019H003);College of Pharmacy,Harbin Medical University Excellent Young Talents Funding(No.2020-YQ-01).; Background:Small ubiquitin-like modifiers(SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer,diabetes,heart failure,and neurological diseases.How...; 关键词：hypertension SUMO inhibitor ERK5 SUMOYLATION KLF2

SIZ1-mediated SUMOylation of CPSF100 promotes plant thermomorphogenesis by controlling alternative polyadenylation: 《Molecular Plant》2024年第9期1392-1406,共15页Zhibo Yu Jun Wang Cheng Zhang Qiuna Zhan Leqian Shi Bing Song Danlu Han Jieming Jiang Junwen Huang Xiaolin Ou Zhonghui Zhang Jianbin Lai Qingshun Quinn Li Chengwei Yang; supported by grants from the Major Program of Guangdong Basic and Applied Research(2019B030302006);the National Natural Science Foundation of China(32000449,32270292,32270344,32270752,and 32170593);the China Postdoctoral Science Foundation(2020M672674);the Program for Changjang Scholars,the Natural Science Foundation of Guangdong Province,China(2024A1515011497,2020B1515020007,and 2024A1515011071);the Guangdong Provincial Pearl River Talent Plan(2019QN01N108);the National Science Foundation of USA(2347540).; Under warm temperatures,plants adjust their morphologies for environmental adaption via precise gene expression regulation.However,the function and regulation of alternative polyadenylation(APA),an important fine-tuni...; 关键词：alternative polyadenylation CPSF100 SiZ1 SUMOYLATION thermomorphogenesis

SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8: 《Cellular & Molecular Immunology》2024年第8期892-904,共13页Jing Guo Hui Zheng Sidong Xiong; National Natural Science Foundation of China(31970844,32170927)to SDX.; Type I interferon(IFN-I)exhibits broad-spectrum antiviral properties and is commonly employed in clinical for the treatment of viral infections.In this study,we unveil SENP6 as a potent regulator of IFN-I antiviral ac...; 关键词：SENP6 SUMOYLATION USP8 IFNAR2 Antiviral activity

构建SUMOylation相关基因的结直肠癌患者临床预后模型: 《哈尔滨医科大学学报》2024年第4期389-395,共7页苏丹阮玉莉马铭刘超王岩; 目的筛选与SUMOylation过程密切相关的基因,并构建结直肠癌的预后基因表达模型。方法从癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中下载与结直肠癌相关的转录组数据和临床资料,结合基因集富集分析(Gene Set Enrichment Analy...; 关键词：结直肠癌 SUMOylation相关基因预测模型列线图癌症基因组图谱数据库

Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma: 《Acta Pharmaceutica Sinica B》2024年第7期2977-2991,共15页Ke Lu Ming Zhang Hongyu Qin Siyu Shen Haiqing Song Hua Jiang Chunxiang Zhang Guozhi Xiao Liping Tong Qing Jiang Di Chen; supported by National Key Research and Development Program of China(2021YFB3800800)to Di Chen and Liping Tong;supported by the National Natural Science Foundation of China(NSFC)grants(82030067,82161160342 and 82250710174)to Di Chen;grant(82302757)to Ke Lu;supported by SIAT Innovation Program for Excellent Young Researchers.; Cyclin D1 has been recognized as an oncogene due to its abnormal upregulation in different types of cancers.Here,we demonstrated that cyclin D1 is SUMOylated,and we identified Itch as a specific E3 ligase recognizing ...; 关键词：Cyclin D1 SUMOYLATION Mantle cell lymphoma Arsenic trioxide SENP2 Proteasome degradation

蛋白质翻译后修饰SUMOylation在肿瘤微环境中的功能作用: 《生物化学与生物物理进展》2024年第6期1256-1268,共13页赵盼盼余俊旭车亚宁梁慧仪黄超; 云南省科技厅基础研究计划(202101BE070001-004);国家自然科学基金(82260461)资助项目。; 目前肿瘤仍然是人类生存中无法克服的一大难题,治疗方案多种多样,但还未找到一种行之有效的方法。随着越来越多的研究发现,人们把治疗肿瘤的目光投向了一种新的领域——肿瘤微环境(tumor microenvironment,TME),指癌细胞周围各种基质细...; 关键词：肿瘤肿瘤微环境蛋白质翻译后修饰 SUMOYLATION

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