Ex vivo STAT3 phosphorylation in circulating immune cells:a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy  

作　　者：Sung-Woo Lee Young Ju Kim Saei Jeong Kyung Na Rho Jeong Eun Noh Hee-Ok Kim Hyun-Ju Cho Yoo Duk Choi Deok Hwan Yang Eu Chang Hwang Woo Kyun Bae Sook Jung Yun Ju Sik Yun Cheol-Kyu Park In-Jae Oh Jae-Ho Cho 

机构地区：[1]Department of Microbiology and Immunology,Chonnam National University Medical School,Hwasunup,Jeollanamdo,Republic of Korea [2]Medical Research Center for Combinatorial Tumor Immunotherapy,Chonnam National University Medical School,Hwasunup,Jeollanamdo,Republic of Korea [3]National Immunotherapy Innovation Center,Chonnam National University Medical School,Hwasunup,Jeollanamdo,Republic of Korea [4]BioMedical Sciences Graduate Program,Chonnam National University Medical School,Hwasunup,Jeollanamdo,Republic of Korea [5]Selecxine Inc.,Seoul,Republic of Korea [6]Department of Internal Medicine,Chonnam National University Medical School,Hwasun Hospital,Hwasunup,Jeollanamdo,Republic of Korea [7]Department of Pathology,Chonnam National University Medical School,Hwasun Hospital,Hwasunup,Jeollanamdo,Republic of Korea [8]Department of Urology,Chonnam National University Medical School,Hwasun Hospital,Hwasunup,Jeollanamdo,Republic of Korea [9]Department of Dermatology,Chonnam National University Medical School,Hwasun Hospital,Hwasunup,Jeollanamdo,Republic of Korea [10]Department of Thoracic and Cardiovascular Surgery,Chonnam National University Medical School,Hwasun Hospital,Hwasunup,Jeollanamdo,Republic of Korea

出　　处：《Cancer Communications》2025年第1期58-62,共5页癌症通讯(英文)

基　　金：funded by National Research Foundation of Korea(2020R1A5A2031185,2020M3A9G3080281,2022R1A2C2009385,2020M3A9G3080330,and 2022R1A6A3A01086438).

摘　　要：Basal signal transducer and activator of transcription 3(STAT3)activation is well-documented in the tumor microenvironment(TME)due to its association with cancer prognosis[1].However,its presence and clinical relevance in the bloodstream remain unexplored.Given that STAT3-inducing cytokines,such as interleukin-6(IL-6),are often elevated in the bloodstream of various cancer patients[2,3],we aimed to investigate basal STAT3 activation in blood by developing a methodology to assess ex vivo phosphorylation of STAT3(pSTAT3ex vivo)in circulating immune cells.

关 键 词：STAT3 VIVO DIAGNOSIS 

分 类 号：R73[医药卫生—肿瘤]