PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA-PK complex  

作　　者：Yue Lang Dexuan Gao Lan Yu Xiang-Xiang Zhang Debabrata Saha Benjamin P.C.Chen Meng-Meng Gu Zeng-Fu Shang 

机构地区：[1]Department of Nuclear Medicine,The Second Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221000,China [2]Department of Nuclear Medicine,The Affliated Suzhou Hospital of Nanjing Medical University,Suzhou,Jiangsu 215002,China [3]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection,Medical College of Soochow University,Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou,Jiangsu 215123,China [4]Department of Urology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China [5]Department of Radiation Oncology,University of Texas Southwestern Medical Center,Dallas,TX75390,USA [6]Department of Pathology,University of Texas Southwestern Medical Center,Dallas,TX 75390,USA

出　　处：《Genes & Diseases》2024年第6期24-27,共4页基因与疾病（英文）

基　　金：funded by grants from the National Natural Science Foundation of China (No.82003226 and 81972964);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);the Natural Science Foundation of Shandong Province (ZR2021MH085).

摘　　要：PDZ and LIM domain protein 1(PDLIM1)is a cytoplasmic LIM protein that regulates cytoskeleton organization and functions as a platform to coordinate various cellular processes.1 Accumulated evidence suggests that PDLIM1 plays important roles in tumorigenesis,tumor progression,and response to cancer therapy.Consistently,our results demonstrated that silencing PDLIM1 significantly inhibited the migration and the invasion of HeLa cells compared with control cells(Fig.S1).However,the feasibility of targeting PDLIM1 as an effective strategy for radiotherapy remains to be determined.

关 键 词：INVASION inhibited DAMAGE 

分 类 号：R73[医药卫生—肿瘤]