THIOREDOXIN

作品数：74被引量：256H指数：8
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相关领域：生物学医药卫生更多>>
相关作者：金伯泉葛青金容姚世响郑斌更多>>
相关机构：第四军医大学南京农业大学华中农业大学北京大学更多>>
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Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway
《Acta Pharmaceutica Sinica B》2025年第2期1007-1022,共16页Xuanzuo Chen Sheng Liu Huiwen Wang Yiran Liu Yan Xiao Kanglu Li Feifei Ni Wei Wu Hui Lin Xiangcheng Qing Feifei Pu Baichuan Wang Zengwu Shao Yizhong Peng 
supported by the National Natural Science Foundation of China(82202764 and 81974352);the China Postdoctoral Science Foundation(2021M701331);Natural Science Foundation of Hubei Province(2020CFB778,China);the Scientific Research Training Program for Young Talents from Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Intervertebral disc degeneration(IDD)is largely attributed to impaired endogenous repair.Nucleus pulposus-derived stem cells(NPSCs)senescence leads to endogenous repair failure.Small extracellular vesicles/exosomes de...
关键词：TXN NRF2 AP-1 Exosomes SENESCENCE Intervertebral disc degeneration NPSCs ESCRT 
Thioredoxin pathway regulated live-cell synthesis of CdSe quantum dots in Saccharomyces cerevisiae
《Science China Chemistry》2024年第11期3851-3860,共10页Xu Li Cai-Qin Wu Jia-Wei Tu Juan Kong Ling-Ling Yang Zhi-Xiong Xie Dai-Wen Pang 
supported by the National Natural Science Foundation of China (22293030, 22293032);the National Key Research and Development Program of China (2019YFA0210100);the Fundamental Research Funds for the Central Universities of China (63211023)。
Currently, the application of synthetic biology to artificially manipulate and utilize organisms for the synthesis of desired products such as nanomaterials with excellent fluorescence properties is attracting conside...
关键词：THIOREDOXIN GLUTATHIONE quantum dot live-cell synthesis selenium metabolism Saccharomyces cerevisiae 
A glycine-rich nuclear effector VdCE51 of Verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhTRXH2
《The Crop Journal》2024年第4期1137-1149,共13页Chi Li Yingqi Huang Wenjing Shang Jieyin Chen Steven J.Klosterman Krishna V.Subbarao Jun Qin Xiaoping Hu 
supported by the National Key Research and Development Program of China(2018YFE0112500);the Natural Science Basic Research Program of Shannxi Province(2024JCYBMS-183).We thank Professor Hui-shan Guo from the Institute of Microbiology,Chinese Academy of Sciences for providing the pNat-Tef-TrpC and pGKO-HPT vector,and Dr.Siwei Zhang from Northwest A&F University for providing the pER8-NeYFP,pER8-CeYFP,and pGEX-4T-1 vectors.
Verticillium dahliae is an important soil-borne fungal pathogen that causes great yield losses in many cash crops.Effectors of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A ...
关键词：Verticillium dahliae Plant immunity EFFECTOR THIOREDOXIN 
Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κB-ROS/NLRP3 Pathway
《Chinese Journal of Integrative Medicine》2023年第10期895-904,共10页YI Jing LI Li YIN Zhu-jun QUAN Yun-yun TAN Rui-rong CHEN Shi-long LANG Ji-rui LI Jiao ZENG Jin LI Yong SUN Zi-jian ZHAO Jun-ning 
the Establishment of Key Disciplines of Traditional Chinese Medicine in Sichuan Province-Pharmacology of Chinese Materia Medica(No.2020ZDXK01);the Systemic Research and Development of Moschus(No.D-2019-6 and D-2019-8)。
Objective To examine the anti-inflammatory effects and potential mechanisms of polypeptide from Moschus(PPM)in lipopolysaccharide(LPS)-induced THP-1 macrophages and BALB/c mice.Methods The polypeptide was extracted fr...
关键词：MOSCHUS POLYPEPTIDE INFLAMMATION NLRP3 inflammasome thioredoxin interacting protein nuclear factorκB Chinese medicine 
Antioxidant activity of the thioredoxin system被引量：2
《Biophysics Reports》2023年第1期26-32,共7页Zihua Liu 
supported by the Cuiying Science and technology Innovation Project(CY2021-MS-B07);Cuiying students'scientific research and cultivation program(CYXZ2020-34);Natural Science Foundation of Gansu Province(22JR5RA987).
The thioredoxin system is composed of thioredoxin(Trx),thioredoxin reductase(TR)and reduced nicotinamide adenine dinucleotide phosphate.Trx is an important antioxidant molecule that can resist cell death caused by var...
关键词：THIOREDOXIN Thioredoxin reductase CANCER Neurodegenerative disease 
Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-κB/p65 activation in cutaneous squamous cell carcinoma
《Oncology Research》2023年第1期71-82,共12页ZHIXUN XIAO QIUYUN XU HAIQING WANG XIAOTONG ZHOU YANTING ZHU CHENGBEI BAO LIHONG CHEN PENG ZHANG MIN LIN CHAO JI TING GONG 
supported by grants from the National Natural Science Fund Youth Fund of China(No.81901164);the Natural Science Foundation of Fujian Province(No.2020J02053);the Natural Science Foundation of Fujian Province(No.2020J01966);the Talent Introduction Project of the First Affiliated Hospital of Fujian Medical University(No.YJRC3813);the Startup Fund for Scientific Research,Fujian Medical University(2020QH2029).
Cutaneous squamous cell carcinoma(cSCC),a type of non-melanoma skin cancer(NMSC),is the most common malignancy worldwide.Thioredoxin(TXN)domain-containing protein 9(TXNDC9)is a member of the TXN family that is importa...
关键词：TXNDC9 Ultra Violet-B(UV-B)radiation Cutaneous squamous cell carcinoma(cSCC) APOPTOSIS NF-κB pathway 
Quantitative proteomics reveals redox-based functional regulation of photosynthesis under fluctuating light in plants
《Journal of Integrative Plant Biology》2022年第11期2168-2186,共19页Qi Chen Yixian Xiao Yu Ming Rong Peng Jiliang Hu Hong-Bin Wang Hong-Lei Jin 
supported by the National Natural Science Foundation of China Grant (31970261);the Talent Support Project of Guangdong (2019TQ05N182)。
Photosynthesis involves a series of redox reactions and is the major source of reactive oxygen species in plant cells.Fluctuating light(FL) levels,which occur commonly in natural environments,affect photosynthesis;how...
关键词：fluctuating light photosystem I PHOTOSYNTHESIS redox regulation THIOREDOXIN 
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension被引量：2
《Genes & Diseases》2022年第3期753-765,共13页Ruiyu Wang Yongzheng Guo Lingjiao Li Minghao Luo Linqian Peng Dingyi Lv Zhe Cheng Qian Xue Liang Wang Jing Huang 
The work was supported by the National Natural Science Foundation of China(No.81370440);the National Science-Technology Support Projects of China(No.2015BAI01B00).
Excessive oxidative stress is a major causative factor of endothelial dysfunction in hypertension.As an endogenous pro-oxidant,thioredoxin-interacting protein(TXNIP)contributes to oxidative damage in various tissues.T...
关键词：Endothelial dysfunction ENOS HYPERTENSION Oxidative stress Thioredoxininteracting protein 
Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxininteracting protein-mediated hypoxia-inducible factor-1αpathway被引量：3
《World Journal of Stem Cells》2022年第2期183-199,共17页Cheng-Yu Mao Tian-Tian Zhang Dong-Jiu Li En Zhou Yu-Qi Fan Qing He Chang-Qian Wang Jun-Feng Zhang 
Supported by National Natural Science Foundation of China,No. 81870264 and No. 81470546;the Shanghai Committee of Science and Technology,No. 18411950500;the Major Disease Joint Project of Shanghai Health System,No. 2014ZYJB0501;Talent Cultivation Project of The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,No. JC202005
BACKGROUND Extracellular vesicles(EVs)derived from hypoxia-preconditioned(HP)mesenchymal stem cells(MSCs)have better cardioprotective effects against myocardial infarction(MI)in the early stage than EVs isolated from ...
关键词：Extracellular vesicles Myocardial infarction Mesenchymal stem cells Hypoxia preconditioning Thioredoxin-interacting protein Hypoxia-inducible factor 1 alpha 
Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response被引量：10
《World Journal of Diabetes》2021年第12期1979-1999,共21页Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy 
Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk ...
关键词：Thioredoxin interacting protein NOD-like receptor pyrin domain containing 3 INFLAMMASOME Interleukin 1b Inflammation Obesity High-fat diet ISCHEMIA REPERFUSION Oxidative stress 
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