Thioredoxin interacting protein,a key molecular switch between oxidative stress and sterile inflammation in cellular response  

作　　者：Islam N Mohamed Luling Li Saifudeen Ismael Tauheed Ishrat Azza B El-Remessy 

机构地区：[1]Department of Pharmaceutical and Biomedical Sciences,College of Pharmacy,California North State University,Elk Grove,CA 95758,United States [2]Department of Anatomy and Neurobiology,and Neuroscience Institute,College of Medicine,University of Tennessee Health Science Center,Memphis,TN 38163,United States [3]Department of Pharmacy,Doctors Hospital of Augusta,Augusta,GA 30909,United States

出　　处：《World Journal of Diabetes》2021年第12期1979-1999,共21页世界糖尿病杂志（英文版）（电子版）

摘　　要：Tissue and systemic inflammation have been the main culprit behind the cellular response to multiple insults and maintaining homeostasis.Obesity is an independent disease state that has been reported as a common risk factor for multiple metabolic and microvascular diseases including nonalcoholic fatty liver disease(NAFLD),retinopathy,critical limb ischemia,and impaired angiogenesis.Sterile inflammation driven by high-fat diet,increased formation of reactive oxygen species,alteration of intracellular calcium level and associated release of inflammatory mediators,are the main common underlying forces in the pathophysiology of NAFLD,ischemic retinopathy,stroke,and aging brain.This work aims to examine the contribution of the pro-oxidative and pro-inflammatory thioredoxin interacting protein(TXNIP)to the expression and activation of NLRP3-inflammasome resulting in initiation or exacerbation of sterile inflammation in these disease states.Finally,the potential for TXNIP as a therapeutic target and whether TXNIP expression can be modulated using natural antioxidants or repurposing other drugs will be discussed.

关 键 词：Thioredoxin interacting protein NOD-like receptor pyrin domain containing 3 INFLAMMASOME Interleukin 1b Inflammation Obesity High-fat diet ISCHEMIA REPERFUSION Oxidative stress 

分 类 号：R364.5[医药卫生—病理学]