supported by the National Key Research and Development Program of China (No.2021YFA1100503);Zhejiang Provincial Natural Science Foundation (China) (No.LY22H160048);Key Research&Development Program of Zhejiang Province (China) (No.2022C03108).
Hepatic steatosis is prevalent worldwide and is characterized as excessive lipid accumulation with/without inflammation and injury in the liver.Hepatic ischemia-reperfusion(HIR)injury commonly occurs in the process of...
BACKGROUND The association between uric acid-albumin ratio(UAR)with different diseases has been evaluated before.However,the association between UAR with spontaneous reperfusion(SR)in patients with ST-segment elevatio...
Post-reperfusion syndrome(PRS)in liver transplant recipients remains one of the most dreaded complications in liver transplant surgery.PRS can impact the short-term and long-term patient and graft outcomes.The definit...
Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and redu...
supported by the National Natural Science Foundation of China(81671228,32321004,92057202,92357308);the Ministry of Science and Technology of China(2021ZD0201702);Joint project of Chongqing Health Commission and Science and Technology Bureau(2023GGXM003);the National Key Research and Development Program of China(2018YFA0800901)。
Constituting 6.5%to 19.6%of all stroke cases worldwide,non-traumatic intracerebral hemorrhage(ICH)represents the most devastating form of stroke,with aging,male gender,and hypertension being important risk factors tha...
upported by the National Key Research and Development Program of China (No.2021YFC2500100);1.3.5 Project for Disciplines of Excellence of West China Hospital of Sichuan University (No.ZYYC23016);the Key Research Projects of Sichuan Province,China (No.24SYSX0093);Major Science&Technology Program of Sichuan Province,China (No.2022ZDZX0021);the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University (China) (No.Z2023LC005);the Natural Science Foundation of Sichuan Province,China (No.2022NSFSC1509);the Fundamental Research Funds for the Central Universities (China) (No.2023SCU12074).
Programmed cell death contributes to neurological damage in ischemic stroke,especially during the reperfusion stage.Several cell death pathways have been tested preclinically and clinically,including ferroptosis,necro...
Supported by the Youth Planning Project of Beijing Scienceand Technology Development Fund for Chinese Medicine(No.QN-2020-14);innovation Fund of China Academy of ChineseMedical Sciences(No.CI2021A00912);Scientific Fund ofNational Clinical Research Center for Chinese Medicine Cardiology(No.CMC2022005)。
Objective:To observe the protective effect and mechanism of hydroxyl safflower yellow A(HsYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs).Methods:HUVECs were treated wi...
supported by the Natural Science Foundation of Anhui Province of China,No.2208085Y32;Scientific Research Plan Project of Anhui Province of China,No.2022AH020076;the Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province,No.CXPJJH12000005-07-115(all to CT).
Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury.Various calcium channels are involved in cerebral ischemia/reperfusion injury.Cav3.2 channel is a main subtype of T-type ...
Cerebrovascular disease is a significant health concern that threatens people’s health and life. About 80% of its burden comes from ischaemic stroke. Early reperfusion therapy is the key to timely restore blood flow ...
supported by the National Natural Science Foundation of China(82027802,82371470,and 82071468).
1.Introduction Stroke remains the second leading cause of death and the third leading cause of death and disability combined worldwide,as indicated by disability-adjusted life-years(DALYs)lost[1].The highest burden of...