Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy  

作　　者：Xun Qiu Hanzhi Xu Yawen Tan Jinying Li Zhoucheng Wang Zhengxing Lian Xuyong Wei Luyang Yu Kai Wang Xiao Xu 

机构地区：[1]Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China [2]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Hangzhou,Zhejiang 310006,China [3]Institute of Genetics and Regenerative Biology,College of Life Sciences,Hangzhou,Zhejiang 310058,China [4]Center for Stem Cell and Regenerative Medicine,Zhejiang University,Hangzhou,Zhejiang 310058,China [5]Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery,Zhejiang Provincial People's Hospital(Affiliated People's Hospital),Hangzhou Medical College,Hangzhou,Zhejiang 310014,China [6]School of Clinical Medicine,Hangzhou Medical College,Hangzhou,Zhejiang 310059,China [7]Institute of Translational Medicine,Zhejiang University,Hangzhou,Zhejiang 310000,China

出　　处：《Genes & Diseases》2025年第2期110-112,共3页基因与疾病(英文)

基　　金：supported by the National Key Research and Development Program of China (No.2021YFA1100503);Zhejiang Provincial Natural Science Foundation (China) (No.LY22H160048);Key Research&Development Program of Zhejiang Province (China) (No.2022C03108).

摘　　要：Hepatic steatosis is prevalent worldwide and is characterized as excessive lipid accumulation with/without inflammation and injury in the liver.Hepatic ischemia-reperfusion(HIR)injury commonly occurs in the process of hemorrhagic shock,liver surgery,and liver transplantation,and impairs liver function by inhibiting the electron transport chain in mitochondria during ischemia stage and producing large amount of reactive oxygen species(RoS)during reperfusion stage.

关 键 词：ischemia REPERFUSION Hepatic 

分 类 号：R57[医药卫生—消化系统]