CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome  

发病到再灌注期间脑出血患者脑脊液的多组学研究:脂质代谢在脑出血功能预后中的价值

作　　者：Yibin Jiang Sin Man Lam Shuixian Zhang Huan Miao Yong Zhou Qian Zhang Tengyuan Zhou Hui Feng Ning Ding Haomiao Wang Ran Luo Yi Yin Hua Feng Guanghou Shui Rong Hu 蒋逸斌;林茜雯;张水仙;苗唤;周勇;张倩;周腾渊;冯慧;丁宁;王浩淼;罗然;尹怡;冯华;税光厚;胡荣

机构地区：[1]Department of Neurosurgery and Key Laboratory of Neurotrauma,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China [2]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [3]Chongqing Key Laboratory on Big Data for Bio Intelligence,Chongqing University of Posts and Telecommunications,Chongqing 400065,China [4]Clinical Medical Research Center,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China

出　　处：《Science Bulletin》2025年第2期162-166,共5页科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(81671228,32321004,92057202,92357308);the Ministry of Science and Technology of China(2021ZD0201702);Joint project of Chongqing Health Commission and Science and Technology Bureau(2023GGXM003);the National Key Research and Development Program of China(2018YFA0800901)。

摘　　要：Constituting 6.5%to 19.6%of all stroke cases worldwide,non-traumatic intracerebral hemorrhage(ICH)represents the most devastating form of stroke,with aging,male gender,and hypertension being important risk factors that predispose individuals to ICH[1,2].Injuries following episodes of ICH can be classified into two forms,namely(1)primary injury arising from mechanical pressure exerted by the hematoma on adjacent tissues,(2)secondary injury resulting from oxidative stress and inflammation mediated by blood cell degradation products and coagulation factors[3].

关 键 词：metabolism HEMORRHAGE INTRACEREBRAL 

分 类 号：R743.34[医药卫生—神经病学与精神病学]