DEFEROXAMINE

作品数：28被引量：210H指数：6
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相关领域：医药卫生更多>>
相关作者：曾进胜孟辉奚国华更多>>
相关机构：密歇根大学常州市第二人民医院第三军医大学西南医院中山大学附属第一医院更多>>
相关期刊：《Genes & Diseases》《Open Journal of Pathology》《World Journal of Hepatology》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke被引量：1
《Genes & Diseases》2024年第6期495-509,共15页Bin Du Zijie Deng Kang Chen Zhangzhong Yang Junfen Wei Liuyao Zhou Jie Meng Ying Cheng Xin Tian Qing-Zhang Tuo Peng Lei 
upported by the National Key Research and Development Program of China (No.2021YFC2500100);1.3.5 Project for Disciplines of Excellence of West China Hospital of Sichuan University (No.ZYYC23016);the Key Research Projects of Sichuan Province,China (No.24SYSX0093);Major Science&Technology Program of Sichuan Province,China (No.2022ZDZX0021);the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University (China) (No.Z2023LC005);the Natural Science Foundation of Sichuan Province,China (No.2022NSFSC1509);the Fundamental Research Funds for the Central Universities (China) (No.2023SCU12074).
Programmed cell death contributes to neurological damage in ischemic stroke,especially during the reperfusion stage.Several cell death pathways have been tested preclinically and clinically,including ferroptosis,necro...
关键词：DEFEROXAMINE Ferroptosis IRON Ischemic stroke NECROPTOSIS 
A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing
《Chinese Chemical Letters》2024年第12期221-227,共7页Haijun Shen Yi Qiao Chun Zhang Yane Ma Jialing Chen Yingying Cao Wenna Zheng 
supported by the National Natural Science Foundation of China(No.82072044);the Qing Lan Project of Jiangsu Province of China。
Diabetic pressure ulcers(DPU)are non-healing due to vascular dysfunction and bacterial infection.Early intervention can delay ulcer progression,such as preventing the formation of full-thickness skin defects.Local adm...
关键词：Diabetic pressure ulcer Transdermal drug delivery Matrix metalloproteinase-sensitive hydrogel ANTIBACTERIAL ANGIOGENESIS 
An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing被引量：4
《Acta Pharmaceutica Sinica B》2023年第10期4318-4336,共19页Jiao Zhang Qian Luo Qian Hu Tiantian Zhang Jingyu Shi Li Kong Dehao Fu Conglian Yang Zhiping Zhang 
supported by funds from National Natural Science Foundation of China(82173760,32101144,China);Program for HUST Academic Frontier Youth Team(2018QYTD13,China)。
Delayed diabetic wound healing has placed an enormous burden on society.The key factors limiting wound healing include unresolved inflammation and impaired angiogenesis.Platelet-rich plasma(PRP)gel,a popular biomateri...
关键词：Injectable hydrogels Diabetic wound healing Platelet-rich plasma LAPONITE DEFEROXAMINE Angiogenesis Macrophage polarization 
Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain
《CCS Chemistry》2023年第1期257-270,共14页Fang Zhu Jian Zhong Junfei Hu Peng Yang Jianhua Zhang Minghua Zhang Yiwen Li Zhipeng Gu 
This work was supported by the National Natural Science Foundation of China(no.52173132)and the Fundamental Research Funds for Central Universities.
Although considerable progress has been achieved in treating iron-overload diseases with deferoxamine(DFO)-based biomaterials,high DFO loading and multifunctional integration in one system are still grand challenges.H...
关键词：carrier-free DEFEROXAMINE NANOPARTICLES iron scavenging reactive oxygen species scavenging 
Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing
《Nano Research》2023年第1期599-612,共14页Huiling Zhong Jun Huang Moucheng Luo Yifei Fang Xinchen Zeng Jun Wu Jianhang Du 
We sincerely acknowledge the funding from the Science and Technology Planning Project of Shenzhen Municipality(Nos.JCYJ20180306174831458 and JCYJ20190807155801657);the National Natural Science Foundation of China(Nos.51973243 and 52173150);Guangdong Innovative and Entrepreneurial Research Team Program(No.2016ZT06S029);Key international(regional)cooperative research projects of the National Natural Science Foundation of China(No.5181001045);The International Science and technology cooperation project of Shenzhen Municipality(No.GJHZ20200731095008026);Public welfare project of Futian District Health Bureau(No.FTWS2021001).
Wound ulceration caused by diabetes is a typical chronic wound wherein healing the local tissue is difficult due to lack of blood vessels and tissue necrosis caused by the long-term accumulation of free radicals.Near-...
关键词：diabetic wound healing near field electrospinning HYDROGEL large pore 
Near-fatal ferrous sulfate poisoning:A case report of successful conservative management
《Journal of Acute Disease》2022年第6期247-250,共4页Wasim S.Shaikh Ayesha Shaikh Sachin Sasane Zeyad Al Rais Mohammed Ali Baqer 
Rationale:Acute iron poisoning is commonly seen in a pediatric population caused by accidental ingestion of iron syrups.We describe a case of iron poisoning who presented to the hospital following intentional near-fat...
关键词：Iron TOXICITY N-ACETYLCYSTEINE DEFEROXAMINE Liver failure 
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1被引量：49
《Acta Pharmaceutica Sinica B》2021年第12期4045-4054,共10页Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao 
supported by the grants National Natural Science Foundation of China (Nos. 81874380 and 82022075, to Xinbing Sui;81730108 and 81973635, to Tian Xie);Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars (No. LR18H160001, to Xinbing Sui);Zhejiang Provincial Natural Science Foundation of China (Nos. LQ20H160013, Ting Duan;LQ21H160038, to Jiao Feng);Zhejiang Province Science and Technology Project of TCM (Nos. 2019ZZ016, to Xinbing Sui;2020ZQ046, to Ruonan Zhang, China)。
Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an acti...
关键词：BAICALIN Ferroptosis Bladder cancer FTH1 DEFEROXAMINE 
Chelation therapy in liver diseases of childhood: Current status and response被引量：1
《World Journal of Hepatology》2021年第11期1552-1567,共16页Jayendra Seetharaman Moinak Sen Sarma 
Chelation is the mainstay of therapy in certain pediatric liver diseases.Copper and iron related disorders require chelation.Wilson’s disease(WD),one of the common causes of cirrhosis in children is treated primarily...
关键词：Wilson’s disease D-PENICILLAMINE Trientine Indian childhood cirrhosis DEFEROXAMINE DEFERASIROX HEMOCHROMATOSIS 
Neuroprotective effect of deferoxamine on erastin-induced ferroptosis in primary cortical neurons被引量：11
《Neural Regeneration Research》2020年第8期1539-1545,共7页Yan Zhang Bao-You Fan Yi-Lin Pang Wen-Yuan Shen Xu Wang Chen-Xi Zhao Wen-Xiang Li Chang Liu Xiao-Hong Kong Guang-Zhi Ning Shi-Qing Feng Xue Yao 
supported by the National Natural Science Foundation of China,Nos.81672171(to XY),81620108018(to SQF),81772342(to GZN);the State Key Laboratory of Medicinal Chemical Biology of Nankai University of China,No.2017027(to XY)
The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury.However,it is unclear whether deferoxamine directly protects neurons from ferroptotic cell death.By comparing the survival rat...
关键词：cystine/glutamate antiporter system light chain DEFEROXAMINE erastin ferroptosis glutathione peroxidase 4 neurons NEUROPROTECTION reactive oxygen species 
Corrigendum: Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis被引量：1
《Neural Regeneration Research》2019年第6期1068-1068,共1页
The original version of the article titled“Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis”contained typographical errors in Graphical Abstract and Abstract section.In Graphi...
关键词：ORIGINAL version ABSTRACT section incorrectly WRITTEN 
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