An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing  

作　　者：Jiao Zhang Qian Luo Qian Hu Tiantian Zhang Jingyu Shi Li Kong Dehao Fu Conglian Yang Zhiping Zhang 

机构地区：[1]Tongji School of Pharmacy,Huazhong University of Science and Technology,Wuhan 430030,China [2]Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China [3]Department of Orthopaedics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China [4]National Engineering Research Center for Nanomedicine,Huazhong University of Science and Technology,Wuhan 430030,China [5]Hubei Engineering Research Center for Novel Drug Delivery System,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第10期4318-4336,共19页药学学报（英文版）

基　　金：supported by funds from National Natural Science Foundation of China(82173760,32101144,China);Program for HUST Academic Frontier Youth Team(2018QYTD13,China)。

摘　　要：Delayed diabetic wound healing has placed an enormous burden on society.The key factors limiting wound healing include unresolved inflammation and impaired angiogenesis.Platelet-rich plasma(PRP)gel,a popular biomaterial in the field of regeneration,has limited applications due to its non-injectable properties and rapid release and degradation of growth factors.Here,we prepared an injectable hydrogel(DPLG)based on PRP and laponite by a simple one-step mixing method.Taking advantages of the non-covalent interactions,DPLG could overcome the limitations of PRP gels,which is injectable to fill irregular injures and could serve as a local drug reservoir to achieve the sustained release of growth factors in PRP and deferoxamine(an angiogenesis promoter).DPLG has an excellent ability in accelerating wound healing by promoting macrophage polarization and angiogenesis in a full-thickness skin defect model in typeⅠdiabetic rats and normal rats.Taken together,this study may provide the ingenious and simple bioactive wound dressing with a superior ability to promote wound healing.

关 键 词：Injectable hydrogels Diabetic wound healing Platelet-rich plasma LAPONITE DEFEROXAMINE Angiogenesis Macrophage polarization 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]