云南高校图书馆联盟文献共享服务平台- DEFERASIROX

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Assessing the auditory effects of oral chelation therapy drug Deferasirox in individuals withβ-thalassemia major: 《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第4期309-314,共6页Balwinder S.Tiwana Ankita Aggarwal Sanjeev Bhagat Harjinder Singh Dimple Sahni Vishav Yadav; Objective:Our study aimed to investigate the ototoxicity associated with the iron chelator deferasirox in patients withβ-thalassemia major,who were receiving regular transfusion therapy,along with evaluating the data...; 关键词：AUDITORY DEFERASIROX distortion product otoacoustic emissions ORAL CHELATING agent pure tone AUDIOMETRY THALASSEMIA

Perforated duodenal ulcer secondary to deferasirox use in a child successfully managed with laparoscopic drainage:A case report: 《World Journal of Clinical Cases》2022年第34期12775-12780,共6页Abdullah Alshehri Tuqa Adil Alsinan; BACKGROUND A perforated gastroduodenal ulcer is rarely observed in children.Certain medications have been reported to cause ulcerations.Deferasirox,an iron chelating agent,has been previously reported to be associated...; 关键词：Peptic ulcer Iron chelating agents DEFERASIROX HEMOGLOBINOPATHIES CHILDREN Case report

The synthesis and antibacterial activity evaluation of oxazolidinone-deferasirox conjugates被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2022年第12期946-952,共7页Xintong Zhao Yuhua Hu Tong Qin Tianlei Li Wenxuan Zhang Song Wu; The CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-028).; We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could co...; 关键词：OXAZOLIDINONE DEFERASIROX ANTIBACTERIAL SIDEROPHORE “Trojan horse”strategy

Determination of deferasirox particle size distribution via laser diffraction and its application in establishing a correlation between particle size and drug dissolution in vitro被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2021年第11期912-923,共12页Yuyuan Chen Song Wu Liqing Chen Yuanyuan Zhang Zhonggao Gao Tianlei Li Wei Huang Qingyun Yang; CAMS Innovation Fund for Medical Sciences(CIFMS No.2016-I2M-3-010 and CIFMS No.2017-I2M-1-011)。; Deferasirox is the first-line drug for iron overload due to thalassemia in adults and pediatric patients. It is classified as a type II compound in the Biopharmaceutics Classification System, and thus the particle siz...; 关键词：DEFERASIROX Particle size distribution Laser diffraction Dissolution curve

Chelation therapy in liver diseases of childhood: Current status and response被引量：1: 《World Journal of Hepatology》2021年第11期1552-1567,共16页Jayendra Seetharaman Moinak Sen Sarma; Chelation is the mainstay of therapy in certain pediatric liver diseases.Copper and iron related disorders require chelation.Wilson’s disease(WD),one of the common causes of cirrhosis in children is treated primarily...; 关键词：Wilson’s disease D-PENICILLAMINE Trientine Indian childhood cirrhosis DEFEROXAMINE DEFERASIROX HEMOCHROMATOSIS

Juvenile hemochromatosis:HAMP mutation and severe iron overload treated with phlebotomies and deferasirox被引量：2: 《World Journal of Clinical Cases》2017年第10期381-383,共3页Manuel A Lescano Letícia C Tavares Paulo C J L Santos; Juvenile hemochromatosis(JH) is a rare condition classified as an autosomal recessive disorder that leads to severe iron absorption. JH usually affects people under the age of 30 and presents symptoms such as chronic ...; 关键词：Genetic disease Juvenile hemochromatosis HAMP gene MUTATION Iron chelation

Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma被引量：3: 《World Journal of Gastroenterology》2016年第40期8967-8977,共11页Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida; Supported by Grants-in-Aid for Scientific Research from the Japan Society for the Program of Science,No.23590978 and No.16H05287;the Strategic Research Promotion Program from Yamaguchi University; AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical studies.METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell...; 关键词：Liver tumor Hepatocellular carcinoma Advanced stage Iron-chelator DEFERASIROX

New developments and controversies in iron metabolism and iron chelation therapy被引量：5: 《World Journal of Methodology》2016年第1期1-19,共19页Christina N Kontoghiorghe George J Kontoghiorghes; Iron is essential for all organisms including microbial,cancer and human cells. More than a quarter of the human population is affected by abnormalities of iron metabolism, mainly from iron deficiency and iron overloa...; 关键词：IRON metabolism IRON CHELATION therapy DEFERIPRONE DEFEROXAMINE DEFERASIROX IRON diseases Medical journals CONTROVERSIES

World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients被引量：1: 《World Journal of Methodology》2014年第3期163-188,共26页Christina N Kontoghiorghe Nicholas Andreou Katerina Constantinou George J Kontoghiorghes; According to global annual estimates hunger/malnutrition is the major cause of death(36 of 62 million). Cardiovascular diseases and cancer(5.44 of 13.43 million) are the major causes of death in developed countries, w...; 关键词：World health issues Global DISEASES Orphandrugs ORPHAN DISEASES Rare DISEASES ORPHAN PATIENTS THALASSAEMIA DEFERIPRONE DEFERASIROX Deferoxamine Iron overload

Low Level Determination of Genotoxic Impurity in Deferasirox Formulation: 《Journal of Analytical Sciences, Methods and Instrumentation》2013年第4期179-183,共5页Pravish Kumar Tiwari Padmakar Sathe Navin Devadiga; 4-hydrazinobenzoic acid has been highlighted as one of the potential genotoxic impurities (PGIs). A sensitive HPLC method was developed and validated for the determination of 4-hydrazino benzoic acid in Deferasirox Ta...; 关键词：DEFERASIROX GENOTOXIC 4-Hydrazinobenzoic ACID HPLC

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