ORPHAN

作品数：44被引量：53H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：屈良鹄卓敏胡娟娟陈昕胡巧霞更多>>
相关机构：中山大学西北农林科技大学华南理工大学华中科技大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《生理科学进展》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划国家教育部博士点基金国家重点基础研究发展计划更多>>
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Exploring the constitutive activation mechanism of the class A orphan GPR20
《Acta Pharmacologica Sinica》2025年第2期500-511,共12页Ming-yang Zhang Jian-yang Ao Ning Liu Ting Chen Shao-yong Lu 
supported by grants from the National Key R&D Program of China(No.2023YFC3404700);the National Natural Science Foundation of China(No.22077082).
GPR20,an orphan G protein-coupled receptor(GPCR),shows significant expression in intestinal tissue and represents a potential therapeutic target to treat gastrointestinal stromal tumors.GPR20 performs high constitutiv...
关键词：G protein-coupled receptor molecular dynamics simulations allosteric communication conformational shift drug discovery 
Enzyme annotation for orphan reactions and its applications in biomanufacturing
《Green Chemical Engineering》2023年第2期137-145,共9页Zhen Zhang Chun Li 
supported by the National Natural Science Foundation of China(22138006).
There are lots of biochemical reactions in the biosynthetic pathway without associated enzymes.Reactions predicted by retro-biosynthetic tools are not assigned gene sequences.Besides,non-natural reactions designed wit...
关键词：Enzyme annotation Orphan reactions Reaction similarity Gene mining Computational enzyme design 
Two target gene activation pathways for orphan ERR nuclear receptors
《Cell Research》2023年第2期165-183,共19页Tomoyoshi Nakadai Miho Shimada Keiichi Ito Murat Alper Cevher Chi-Shuen Chu Kohei Kumegawa Reo Maruyama Sohail Malik Robert G Roeder 
NIH grants DK071900 and CACA234575 to R.G.R.T.N.was supported by JSPS KAKENHI(19K07651);M.S.was supported by JSPS KAKENHI(19K06482);K.I.by an NCI T32 grant(CA009673);JSPS fellowship for research abroad;M.A.C.by an American Cancer Society Eastern Division-New York Cancer Research Fund Postdoctoral Fellowship.
Estrogen-related receptors(ERRα/β/γ)are orphan nuclear receptors that function in energy-demanding physiological processes,as well as in development and stem cell maintenance,but mechanisms underlying target gene a...
关键词：ACTIVATION TEMPLATE ERR 
Orphan patients with inflammatory bowel disease-when we treat beyond evidence
《World Journal of Gastroenterology》2021年第47期8047-8057,共11页Giuseppe Privitera Daniela Pugliese Loris Riccardo Lopetuso Franco Scaldaferri Alfredo Papa GianLodovico Rapaccini Antonio Gasbarrini Alessandro Armuzzi 
Inflammatory bowel disease(IBD)is a chronic condition that requires continuous medical treatment.To date,the medical management of patients with moderatelyto-severely active IBD who develop dependence or resistance to...
关键词：POUCHITIS PROCTITIS STOMA Short-bowel Ileo-rectal anastomosis BIOLOGICS 
Issues in conserving'orphan heritage'in Asia:WWIl battlefield conservation in Hong Kong and Malaysia被引量：1
《Built Heritage》2021年第2期66-85,共20页Yi-Wen Wang Jesse DiMeolo Gao Du 
the Research Development Fund and the Postgraduate Research Scholarship(RDF-16-01-22).
Wars and conflict have existed since the beginning of time.Most battlefield conservation work is done for battlefields that lie in the borders of the nations that were involved,thus fostering citizens'personal ties wi...
关键词：World warⅡ BATTLEFIELDS CONSERVATION transnational heritage post-colonial countries 
Orphan Crops and their Wild Relatives in the Genomic Era被引量：5
《Molecular Plant》2021年第1期27-39,共13页Chu-Yu Ye Longjiang Fan 
This work was funded in part by the National Natural Science Foundation of China(31971865);the Zhejiang Natural Science Foundation(LZ17C130001);the Innovation Method Project of China(2018IM0301002).
More than half of the calories consumed by humans are provided by three major cereal crops(rice,maize,and wheat).Orphan crops are usually well adapted to low-input agricultural conditions,and they not only play vital ...
关键词：orphan crop wild relative WEED genome crop diversity 
Three-dimensional aspects of formulation excipients in drug discovery:a critical assessment on orphan excipients,matrix effects and drug interactions
《Journal of Pharmaceutical Analysis》2020年第6期522-531,共10页Vijayabhaskar Veeravalli Hanumanth Srikanth Cheruvu Pratima Srivastava Lakshmi Mohan Vamsi Madgula 
Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete availability.Many excipients used in pharmaceutical f...
关键词：Formulation excipients PRECLINICAL Drug discovery Matrix effects Drug interactions BIOANALYSIS PHARMACOKINETICS Formulation development 
Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice被引量：4
《Cell Research》2020年第4期363-365,共3页Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang 
This work was supported by grants from the National Natural Science Foundation of China(31570807,31771304,91754101,91857000);the National Key Research and Development Program of China(2016YFA0500100,2018YFA0800700);the 111 Project of China(B16036);the Fundamental Research Funds for the Central Universities of China(2042017kf0240,2042017kf0187);the Key Research and Development Program of Hubei province(2019CFA067);state key laboratory of Natural Medicines(SKLNMKF201902).
Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-...
关键词：CHOLESTEROL CARDIOVASCULAR BLOOD 
Effect of isoflurane on expression of NR4A1 in hypoxic pulmonary artery
《Journal of Hainan Medical University》2019年第17期25-28,共4页Rong Liu Zhi-Yong Xu Hao Weng Ding-Ding Huang 
supported by the Seed Fund Program of Shanghai University of Medicine&Health Sciences(Grant No.HMSF-16-22-026).
Objective: To investigate the effects of emulsified isoflurane on hypoxic pulmonary artery endothelial cells (HPAECs) injury and orphan nuclear receptor subfamily 4A1 (NR4A1) expression. Methods: HPAECs were divided i...
关键词：EMULSIFIED ISOFLURANE Hypoxia Endothelial cell injury Proliferation Apoptosis ORPHAN nuclear receptor SUBFAMILY 4A1 
Origination and evolution of orphan genes and de novo genes in the genome of Caenorhabditis elegans被引量：6
《Science China(Life Sciences)》2019年第4期579-593,共15页Wenyu Zhang Yuanxiao Gao Manyuan Long Bairong Shen 
supported by EEgrid cluster of the University of Chicago;supported by National Natural Science Foundation of China(31600670 to W.Zhang,31670851 to B.Shen)
Orphan genes that lack detectable homologues in other lineages could contribute to a variety of biological functions. However,their origination and function mechanisms remain largely unknown. Herein, through a compreh...
关键词：CAENORHABDITIS elegans orphan GENES de novo GENES 
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