Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice  

作　　者：Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang 

机构地区：[1]Hubei Key Laboratory of Cell Homeostasis,College of Life Sciences,Wuhan University,430072 Wuhan,Hubei,China [2]Princess Margaret Cancer Centre,University Health Network,Toronto,ON MSG 1L7,Canada [3]Department of Medical Biophysics,University of Toronto,Toronto,ON M5S 3G3,Canada

出　　处：《Cell Research》2020年第4期363-365,共3页细胞研究（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(31570807,31771304,91754101,91857000);the National Key Research and Development Program of China(2016YFA0500100,2018YFA0800700);the 111 Project of China(B16036);the Fundamental Research Funds for the Central Universities of China(2042017kf0240,2042017kf0187);the Key Research and Development Program of Hubei province(2019CFA067);state key laboratory of Natural Medicines(SKLNMKF201902).

摘　　要：Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-wide association study(GWAS)is a powerful tool to ascertain the contribution of common genetic variants in population-wide disease variability.It has been performed extensively on blood lipids traits and hundreds of genome variants are associated with dyslipidemia.However,approximately 95%of these variants are located in genome noncoding regions and cluster in more than 300 loci in different populations.

关 键 词：CHOLESTEROL CARDIOVASCULAR BLOOD 

分 类 号：R589.2[医药卫生—内分泌]