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SUBFAMILY: 作品数：120被引量：238H指数：8; 导出分析报告; 相关领域：生物学医药卫生更多>>; 相关作者：张雅林祝钦泷郭余龙李名扬郑尚永更多>>; 相关机构：中山大学中华人民共和国农业部西南大学教育部更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山西省自然科学基金国家高技术研究发展计划更多>>

Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis:Implications for gut-liver axis imbalance: 《World Journal of Hepatology》2025年第4期75-84,共10页Yi-Zhi Pan Wan-Ting Chen Hao-Ran Jin Zhen Liu Ying-Ying Gu Xin-Ruo Wang Jue Wang Jing-Jing Lin Yan Zhou Lan-Man Xu; Supported by Key Project of the Ningbo Natural Science Foundation,Zhejiang Province,China,No.2022J253;Key Technology R&D Project of Ningbo City,No.2023Z208;Traditional Chinese Medicine project,Zhejiang Province,No.2024ZF028;the Key Project of Health Science and Technology Foundation,Zhejiang Province,China,No.WKJ-ZJ-2551.; BACKGROUND Liver cirrhosis(LC)affect millions of people worldwide.The pathogenesis of cirrhosis involves complex interactions between immune responses and gut microbiota.Recent studies have highlighted the role of the...; 关键词：Interleukin-36 Interleukin-36γ Interleukin-38 Liver cirrhosis Gut microbiota

Clinical,genetic and functional perspectives on ATP-binding cassette subfamily B member 4 variants in five cholestasis adults: 《World Journal of Gastroenterology》2025年第14期142-156,共15页Yu-Hang Weng Yu-Feng Zheng Dan-Dan Yin Qing-Fang Xiong Jin-Long Li Shun-Xin Li Wei Chen Yong-Feng Yang; Supported by the National Natural Science Foundation of China,No.81970454.; BACKGROUND ATP-binding cassette subfamily B member 4(ABCB4)deficiency is associated with cholestatic liver disease primarily because of missense mutations,and many variants remain unidentified.Here,we validate the pat...; 关键词：ATP-binding cassette subfamily B member 4 Multidrug resistance protein 3 CHOLESTASIS Functional analysis CLINICAL Gene mutation Whole-exome sequencing

NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway: 《World Journal of Diabetes》2025年第3期203-215,共13页Jin-Meng Li Zi-Hua Song Yuan Li Han-Wen Chen Han Li Lu Yuan Jing Li Wen-Yue Lv Lei Liu Na Wang; Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.; BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...; 关键词：Diabetes Diabetic kidney disease PYROPTOSIS FIBROSIS Nuclear receptor subfamily 4 group A member 1

Targeting NR1D1 in organ injury:challenges and prospects: 《Military Medical Research》2024年第6期887-906,共20页Zi-Yin Zhang-Sun Xue-Zeng Xu Germaine Escames Wang-Rui Lei Lin Zhao Ya-Zhe Zhou Ye Tian Ya-Nan Ren Darío Acuña-Castroviejo Yang Yang; supported by the National Natural Science Foundation of China(82070422,82200330);the China Postdoctoral Science Foundation(2023T160526 and 2022M722571);the Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);the High-end Foreign Expert Introduction Program of National Science and Technology(G2022040014L);the Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).; Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In a...; 关键词：Nuclear receptor subfamily 1 group D member 1(NR1D1) Circadian rhythms Liver HEART LUNG KIDNEY

Elevated ETV4 expression in cholangiocarcinoma is linked to poor prognosis and may guide targeted therapies: 《World Journal of Gastrointestinal Oncology》2024年第11期4528-4531,共4页Uchenna E Okpete Haewon Byeon; Cholangiocarcinoma(CCA),a highly aggressive bile duct cancer,is associated with late-stage diagnosis and limited treatment options,leading to poor patient outcomes.Early detection and personalized treatment strategies...; 关键词：Prognostic biomarkers CHOLANGIOCARCINOMA Survival rates ETV4 expression PEA3 subfamily Precision medicine Targeted therapy

Biogeographic analysis based on phylogenomic data supports multiple ancient dispersals that facilitated the eastern Asia–North America–Mexico disjunction in the subfamily Linnaeoideae(Caprifoliaceae): 《Journal of Systematics and Evolution》2024年第5期1025-1036,共12页Hong-Xin Wang Diego F.Morales-Briones Jacob B.Landis Jun Wen Hua-Feng Wang; supported by the National Natural Science Foundation of China(32270221);the Project of Sanya Yazhou Bay Science and Technology City(Grant No.SCKJ-JYRC-2022-83);Hainan Province Science and Technology Special Fund(ZDYF2022XDNY190,ZDYF2022XDNY176);funding from the Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture,Hainan University(XTCX2022NYB09);Innovation Fund for Scientific and Technological Personnel of Hainan Province and Hainan Provincial Natural Science Foundation of China(421RC486,320RC672).; The small subfamily Linnaeoideae of Caprifoliaceae exhibits a disjunct distribution in Eurasia and North America,including Mexico,with most taxa occurring in eastern Asia or Mexico and the monospecific Linnaea Gronov....; 关键词：BIOGEOGRAPHY divergence time estimation Linnaeoideae PHYLOGENOMICS

Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma被引量：1: 《World Journal of Gastrointestinal Oncology》2024年第9期4014-4027,共14页Li Wang Zhe Zhang Hai-Zhang Ma; Science and Technology Development Plan Project of Hangzhou,No.20201203B56.; BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor prognosis.The PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles...; 关键词：PEA3 subfamily CHOLANGIOCARCINOMA The cancer genome atlas ETV4 The prognosis Prognostic biomarker

Study on the correlation between nuclear receptor subfamily 2 group E member 1 and chronic inflammatory status in patients with metabolic associated fatty liver disease: 《China Medical Abstracts(Internal Medicine)》2024年第3期160-160,共1页XIONG Qing; Objective To investigate the relationship between nuclear receptor subfamily 2 group E member 1 (NR2E1)and chronic inflammatory status in metabolic associated fatty liver disease (MAFLD).Methods A total of 32 MAFLD pa...; 关键词：PATIENTS liver INFLAMMATORY

承德无角山羊KCNJ15基因核心启动子区鉴定: 《农业生物技术学报》2024年第9期2081-2087,共7页张文浩刘爽韩聪洪支林谢遇春乔贤刘铮铸巩元芳; 河北省羊产业技术体系创新团队遗传资源开发与利用岗项目(HBCT2023200201)。; 角是山羊(Capra hircus)的重要表型性状,KCNJ15 (potassium inwardly rectifying channel subfamily J member 15)是影响山羊角生长的重要基因之一。本研究以承德无角山羊为实验动物,利用PCR技术扩增KCNJ15基因2 353 bp长度序列(起始密...; 关键词：承德无角山羊 KCNJ15(potassium inwardly rectifying channel subfamily J member 15)基因核心启动子区

Potassium voltage-gated channel subfamily H member 2(KCNH2)is a promising target for incretin secretagogue therapies被引量：1: 《Signal Transduction and Targeted Therapy》2024年第9期4079-4090,共12页Ying-Chao Yuan Hao Wang Ze-Ju Jiang Chang Liu Qi Li Si-Rui Zhou Jin-Kui Yang; supported by grants from the National Natural Science Foundation of China(81930019)to Jin-Kui Yang;supported by grants from Beijing Municipal Natural Science Foundation(7232232)to Hao Wang。; Derived from enteroendocrine cells(EECs),glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic peptide(GIP)are pivotal incretin hormones crucial for blood glucose regulation.Medications of GLP-1 analogs a...; 关键词：KCNH2 POTASSIUM elevated

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