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作品数：118被引量：236H指数：8
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NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway
《World Journal of Diabetes》2025年第3期203-215,共13页Jin-Meng Li Zi-Hua Song Yuan Li Han-Wen Chen Han Li Lu Yuan Jing Li Wen-Yue Lv Lei Liu Na Wang 
Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.
BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...
关键词：Diabetes Diabetic kidney disease PYROPTOSIS FIBROSIS Nuclear receptor subfamily 4 group A member 1 
Targeting NR1D1 in organ injury:challenges and prospects
《Military Medical Research》2024年第6期887-906,共20页Zi-Yin Zhang-Sun Xue-Zeng Xu Germaine Escames Wang-Rui Lei Lin Zhao Ya-Zhe Zhou Ye Tian Ya-Nan Ren Darío Acuña-Castroviejo Yang Yang 
supported by the National Natural Science Foundation of China(82070422,82200330);the China Postdoctoral Science Foundation(2023T160526 and 2022M722571);the Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);the High-end Foreign Expert Introduction Program of National Science and Technology(G2022040014L);the Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036).
Nuclear receptor subfamily 1,group D,member 1(NR1D1,also known as REV-ERBα)belongs to the nuclear receptor(NR)family,and is a heme-binding component of the circadian clock that consolidates circadian oscillators.In a...
关键词：Nuclear receptor subfamily 1 group D member 1(NR1D1) Circadian rhythms Liver HEART LUNG KIDNEY 
Elevated ETV4 expression in cholangiocarcinoma is linked to poor prognosis and may guide targeted therapies
《World Journal of Gastrointestinal Oncology》2024年第11期4528-4531,共4页Uchenna E Okpete Haewon Byeon 
Cholangiocarcinoma(CCA),a highly aggressive bile duct cancer,is associated with late-stage diagnosis and limited treatment options,leading to poor patient outcomes.Early detection and personalized treatment strategies...
关键词：Prognostic biomarkers CHOLANGIOCARCINOMA Survival rates ETV4 expression PEA3 subfamily Precision medicine Targeted therapy 
Biogeographic analysis based on phylogenomic data supports multiple ancient dispersals that facilitated the eastern Asia–North America–Mexico disjunction in the subfamily Linnaeoideae(Caprifoliaceae)
《Journal of Systematics and Evolution》2024年第5期1025-1036,共12页Hong-Xin Wang Diego F.Morales-Briones Jacob B.Landis Jun Wen Hua-Feng Wang 
supported by the National Natural Science Foundation of China(32270221);the Project of Sanya Yazhou Bay Science and Technology City(Grant No.SCKJ-JYRC-2022-83);Hainan Province Science and Technology Special Fund(ZDYF2022XDNY190,ZDYF2022XDNY176);funding from the Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture,Hainan University(XTCX2022NYB09);Innovation Fund for Scientific and Technological Personnel of Hainan Province and Hainan Provincial Natural Science Foundation of China(421RC486,320RC672).
The small subfamily Linnaeoideae of Caprifoliaceae exhibits a disjunct distribution in Eurasia and North America,including Mexico,with most taxa occurring in eastern Asia or Mexico and the monospecific Linnaea Gronov....
关键词：BIOGEOGRAPHY divergence time estimation Linnaeoideae PHYLOGENOMICS 
Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma被引量：1
《World Journal of Gastrointestinal Oncology》2024年第9期4014-4027,共14页Li Wang Zhe Zhang Hai-Zhang Ma 
Science and Technology Development Plan Project of Hangzhou,No.20201203B56.
BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor prognosis.The PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles...
关键词：PEA3 subfamily CHOLANGIOCARCINOMA The cancer genome atlas ETV4 The prognosis Prognostic biomarker 
Study on the correlation between nuclear receptor subfamily 2 group E member 1 and chronic inflammatory status in patients with metabolic associated fatty liver disease
《China Medical Abstracts(Internal Medicine)》2024年第3期160-160,共1页XIONG Qing 
Objective To investigate the relationship between nuclear receptor subfamily 2 group E member 1 (NR2E1)and chronic inflammatory status in metabolic associated fatty liver disease (MAFLD).Methods A total of 32 MAFLD pa...
关键词：PATIENTS liver INFLAMMATORY 
承德无角山羊KCNJ15基因核心启动子区鉴定
《农业生物技术学报》2024年第9期2081-2087,共7页张文浩 刘爽 韩聪 洪支林 谢遇春 乔贤 刘铮铸 巩元芳 
河北省羊产业技术体系创新团队遗传资源开发与利用岗项目(HBCT2023200201)。
角是山羊(Capra hircus)的重要表型性状,KCNJ15 (potassium inwardly rectifying channel subfamily J member 15)是影响山羊角生长的重要基因之一。本研究以承德无角山羊为实验动物,利用PCR技术扩增KCNJ15基因2 353 bp长度序列(起始密...
关键词：承德无角山羊 KCNJ15(potassium inwardly rectifying channel subfamily J member 15)基因 核心启动子区 
Potassium voltage-gated channel subfamily H member 2(KCNH2)is a promising target for incretin secretagogue therapies
《Signal Transduction and Targeted Therapy》2024年第9期4079-4090,共12页Ying-Chao Yuan Hao Wang Ze-Ju Jiang Chang Liu Qi Li Si-Rui Zhou Jin-Kui Yang 
supported by grants from the National Natural Science Foundation of China(81930019)to Jin-Kui Yang;supported by grants from Beijing Municipal Natural Science Foundation(7232232)to Hao Wang。
Derived from enteroendocrine cells(EECs),glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic peptide(GIP)are pivotal incretin hormones crucial for blood glucose regulation.Medications of GLP-1 analogs a...
关键词：KCNH2 POTASSIUM elevated 
Molecular phylogeny and taxonomy of Phlomoides(Lamiaceae subfamily Lamioideae)in China:Insights from molecular and morphological data
《Plant Diversity》2024年第4期462-475,共14页Yue Zhao Ya-Ping Chen Bryan T.Drew Fei Zhao Maryam Almasi Orzimat T.Turginov Jin-Fei Xiao Abdul G.Karimi Yasaman Salmaki Xiang-Qin Yu Chun-Lei Xiang 
funded by the National Natural Science Foundation of China (No.32161143015);International Partnership Program of Chinese Academy of Sciences (070GJHZ202211FN);the Natural Science Foundation of Yunnan Province (202001AS070016);the"Ten Thousand Talents Program of Yunnan" (Top-notch Young Talents Project,No.YNWR-QNBJ-2018-279);the CAS Interdisciplinary Team of the"Light of West China"program;Yunnan Revitalization Talent Support Program"Innovation Team"project to CLX;the Iran National Science Foundation to YS (4001651);the open research project of the Germplasm Bank of Wild Species,Kunming Institute of Botany,Chinese Academy of Sciences。
Phlomoides,with 150-170 species,is the second largest and perhaps most taxonomically challenging genus within the subfamily Lamioideae(Lamiaceae).With about 60 species,China is one of three major biodiversity centers ...
关键词：Lamioideae Molecular phylogenetics MORPHOLOGY Phlomideae TAXONOMY 
Genome-Wide Identification of ABCC Gene Subfamily Members and Functional Analysis of CsABCC11 in Camellia sinensis
《Phyton-International Journal of Experimental Botany》2024年第8期2019-2036,共18页Mingyuan Luo Shiyu Tian Xinzhuan Yao Yue Wan Zhouzhuoer Chen Zifan Yang Huagen Hao Fei Liu Hu Tang Litang Lu 
supported by the Guizhou University Talent Introduction Program([2021]05);Guizhou University Cultivation Program([2020]48);Institute of Technology of YF([2022]017);Guizhou Province High-Level Innovative Talents“Hundred”Level Talent Project(Qiankehe Platform Talent)GCC[2023]014;Supported by the earmarked fund for GZMARS-Tea and Research on the Planting Technology of China HUANENG Photovoltaic Tea Garden(Project No.HNKJ2022-H135).
The ATP-binding cassette(ABC)transporter is a gene superfamily in plants.ATP-binding cassette subfamily C(ABCC)protein is a multidrug resistance-associated(MRP)transporter.They play various roles in plant growth,devel...
关键词：Camellia sinensis ABCC gene subfamily EGCG VIGS guizhou local variety Kingbird 
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