OXAZOLIDINONE

作品数：17被引量：15H指数：2
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相关领域：理学医药卫生更多>>
相关作者：郭月芳李荣坡周伟澄何良年王金泉更多>>
相关机构：上海医药工业研究院南开大学更多>>
相关期刊：《Science China Chemistry》《Chemical Research in Chinese Universities》《有机化学》《Journal of Integrative Agriculture》更多>>
相关基金：国家自然科学基金浙江省重点科技创新团队项目更多>>
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Tandem asymmetric propargylic amination/carboxylative cyclization reaction to chiral 5-methylidene-2-oxazolidinones using CO_(2) as C1 synthon
《Science China Chemistry》2025年第4期1402-1411,共10页Zheng Zhang Zhi-Hao Zhang Ying Sun Yun-Hao Tang Yi-Zhuo Yang Feng Zhou Jian Zhou 
supported by the National Natural Science Foundation of China(21871090,21725203);the National Key Research and Development Program of China(2020YFA0710200);the Shanghai Science and Technology Innovation Action Plan(20JC1416900);the Innovation Program of Shanghai Municipal Education Commission(2023ZKZD37);the Fundamental Research Funds for the Central Universities.
We report a tandem asymmetric Cu-catalyzed propargylic amination(ACPA)/Ag-catalyzed carboxylative cyclization(SCC)with CO_(2) to 5-methylidene-2-oxazolidinones;even with tetrasubstituted stereocenters.By varying pyrid...
关键词：CO_(2) 2-oxazolidinone tandem sequence propargylic amination carboxylative cyclization 
Metal Acetylacetonates as Robust Catalysts for the Synthesis of Oxazolidinone from CO_(2);Aziridine Under Atmospheric Pressure
《Chemical Research in Chinese Universities》2024年第6期1041-1049,共9页LI Bohan GONG Yujie LOU Huimin WEI Yujuan GUO Liping WANG Hongmei ZHANG Zulei LI Lei 
supported by the Program for Public Technology of Jiaxing Province,China (No.2023AD11041);the Natural Science Foundation of Zhejiang Province,China (No.LY22E020009);the National Undergraduate Training Programs for Innovation of China (No.202110354038);the Student Research Training Program of Jiaxing University,China (No.8517231462).
Metal acetylacetonates,a type of readily synthesized or commercially available metal complex,were demonstrated to be robust catalysts for the synthesis of oxazolidinone from CO_(2);aziridine under condition of atmosph...
关键词：Metal acetylacetonate Carbon dioxide AZIRIDINE OXAZOLIDINONE Atmospheric pressure 
First identification of the oxazolidinone/phenicol resistance gene optrA in Streptococcus pluranimalium worldwide
《Journal of Integrative Agriculture》2024年第2期731-734,共4页Kuan Zhao Longyu Zhou Shixia Zhang Wanjiang Zhang Yao Zhu 
supported by the National Key Research and Development Program of China(2022YFF0710505);The Central Public-interest Scientific Institution Basal Research Fund,China(1610302022001);the Talents Introduction Projects of Hebei Agricultural University,China(YJ201945)。
Oxazolidinones are highly effective antimicrobial agents for the treatment of serious infections caused by Gram-positive organisms,including methicillin-resistant Staphylococcus aureus(MRSA),vancomycin-resistant enter...
关键词：resistance PREVALENCE 
The synthesis and antibacterial activity evaluation of oxazolidinone-deferasirox conjugates被引量：1
《Journal of Chinese Pharmaceutical Sciences》2022年第12期946-952,共7页Xintong Zhao Yuhua Hu Tong Qin Tianlei Li Wenxuan Zhang Song Wu 
The CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-028).
We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could co...
关键词：OXAZOLIDINONE DEFERASIROX ANTIBACTERIAL SIDEROPHORE “Trojan horse”strategy 
Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety
《Chemical Research in Chinese Universities》2018年第1期51-56,共6页XU Boxuan DING Xiudong WU Yachuang CUI Lei QIAN Ping WANG Di ZHAO Yanfang 
A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ^1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacte...
关键词：Oxazolidinone derivative Antibacterial activity LINEZOLID Ranbezolid 
Synthesis,Crystal Structure and Anticoagulant Activity of 5-Chloro-N-[[(5S)-2-oxo-3-[4-(2-oxopyridin-1(2H)-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide被引量：1
《Chinese Journal of Structural Chemistry》2014年第7期1091-1095,共5页刘巍 袁静 张士俊 徐为人 黄长江 汤立达 
Supported by Key Projects of Tianjin Science and Technology Support Plan(12ZCZDSY01100)
The title compound （zifaxaban 2, C20HI6C1N3O4S, Mr = 429.87） was synthesized and its crystal structure was determined by single-crystal X-ray diffraction. Zifaxaban crystallizes in monoclinic, space group P21 with a...
关键词：SYNTHESIS crystal structure OXAZOLIDINONE factor Xa inhibitor zifaxaban 
A facile synthesis of the oxazolidinone antibacterial agent linezolid
《Chinese Chemical Letters》2013年第3期230-232,共3页Yan-Wu Li Yan Liu Yun-Can Jia Jian-Yong Yuan 
supported by Natural Science Foundation Project of CQ CSTC
A facile synthetic route of linezolid 1 has been developed. Using commercially available （R）- epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coup...
关键词：LinezolidSynthesisGoldberg coupling reaction 
Development of An Enzyme-Linked Immunosorbent Assay for Determination of the Furaltadone Etabolite,3-Amino-5-Morpholinomethyl-2-Oxazolidinone(AMOZ) in Animal Tissues被引量：4
《Biomedical and Environmental Sciences》2012年第4期449-457,共9页LUO Peng Jie JIANG Wen Xiao BEIER Ross C. SHEN Jian Zhong JIANG Hai Yang MIAO Hong ZHAO Yun Feng CHEN Xia WU Yong Ning 
supported by the National Science Foundation for Young Scientists of China(No.21107104);the State Key Program of National Natural Science of China(No.20837003);grants from the Ministry of Health(No.200902009);the National Science&Technology Pillar Program(No.2009BADB9B03-Z02)
Objective To determine 3-amino-5-morpholinomethyl-2-oxazolidinone （AMOZ） residues released from protein bound AMOZ in animal tissues. Methods Polyclonal and monoclonal antibodies were produced in this study. A rapid...
关键词：AMOZ Animal tissue ELISA Fish tissue Furaltadone 
Efficient catalyst-free chemical fixation of carbon dioxide into 2-oxazolidinones under supercritical condition
《Chinese Chemical Letters》2011年第9期1063-1066,共4页Jing Xiu Xu Jin Wu Zhao Zhen Bin Jia 
supported financially by Youth Foundation of Guangdong Medical College(No.XQ1029);Science and Technology Planning Project of Zhanjiang city(No.2009c3103024)
4-Methylene-1,3-oxazolidin-2-ones can be synthesized from propargylic alcohols, primary amines and carbon dioxide under supercritical condition in the absence of any additional catalyst and solvent. Various propargyli...
关键词：CATALYST-FREE Carbon dioxide SUPERCRITICAL 2-Oxazolidinone 
Antigens synthesis and antibodies preparation for furazolidone and its metabolite 3-amino-2-oxazolidinone被引量：7
《Chinese Chemical Letters》2010年第9期1049-1052,共4页Hua Ping Zhu Ting Ting Liu Bing Liu Hui Ling Yin Xiao Long Li Li Wang Shuo Wang 
supports from the Ministry of Science and Technology of the People's Republic of China(No.2009ZX09502-027 and No.2009BADB9B03).
Two haptens of 3-[（5-amino-furan-2-ylmethylene）amino]oxazolidin-5-one（FZ-NH_2） and 3-{[（4-carboxyphenyl）methylene]-amino} -2-oxazolidinone（CPAOZ） were synthesized.For FZ-NH2,immunogens were prepared by glutara...
关键词：Furzolidone AOZ ANTIGEN Antibody ELISA 
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