supported by the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.RF-A2022013);the program of the National Natural Science Foundation of China(No.42276137);the National Key Research and Development Programs(Nos.2022YFC2804104,and 2022YFC2804700).
Rare actinomycete genera are highly recognized as a promising source of structurally diverse and bioactive natural products.Among these genera,Allokutzneria and Kibdelosporangium are two phylogenetically closely relat...
funded by the National Natural Science Foundation of China(Grant number 31971554);Guangdong Basic and Applied Basic Research Foundation,China(Grant number 2023A1515011565);Project for Key Technologies R&D Innovation Team in Modern Agriculture,Guangdong(2022KJ134,2023KJ134).
Biochar can potentially reduce heavy metals(HMs)mobility and bioavailability during composting.However,siderophores secreted by functional microbes might lead to the re-mobilization of metals like Cu and Zn.Therefore,...
Iron is an essential but excessively toxic nutrient. Although iron is rich in nature, the acquisition of iron is a challenge to life. Its solubility is very low because it is mostly in the form of oxidation or hydroxi...
support from the Helmholtz International Lab(InterLabs0007);Yuhao Ren acknowledges the support from the International Postdoctoral Exchange Fellowship Program(ZD202125)between Helmholtz Association;Germany and the Office of China Postdoc Council(OCPC),China.
The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense.In this paper,we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and ch...
supported by the National Key R&D Program of China(2019YFA0905700);National Natural Science Foundation of China(32070060).
Iron is essential for bacterial survival,and most bacteria capture iron by producing siderophores.Burkholde-riales bacteria produce various types of bioactive secondary metabolites,such as ornibactin and malleobactin ...
Supported by the Natural Foundation of Zhejiang Province(No.LGF21H300003);the Key Laboratory of Tropical Marine Ecosystem and Bioresource,Ministry of Natural Resources(No.2021QN03);the Key Research and Development Program of Zhejiang Province(No.2021C03084);the Key Research and Development Program of National Key R&D Program of China(Nos.2018YFC0311003,2017YFE0103100);the High Level Talent Special Support Plan of Zhejiang Province(No.2019R52009).We also gratefully acknowledge platform support from Zhejiang International Sci-Tech Cooperation Base for the Exploitation and Utilization of Nature Product。
This chemical study reports a novel siderophore-like compound,β-cyclopiazonic acid(1,β-CPA)extracted from marine fungus Aspergillus flavus.The chemical structure ofβ-CPA was elucidated by a combination of extensive...
supported by grants from the National Key Research and Development Program of China(Grant No.2022YFC2302900);the National Natural Science Foundation of China(Grant No.32171217 to B.Z.);Shanghai Sailing Program(Grant No.21YF1429700 to B.Z.);Young Elite Scientists Sponsorship Program by CAST(Grant No.2021QNRC001);the Lingang Laboratory(Grant No.LG202101-01-08);Shanghai Municipal Science and Technology Major Project(Grant No.ZD2021CY001);Science and Technology Commission of Shanghai Municipality(Grant No.20XD1422900 to H.Y.);the Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine,Shanghaitech University.
The adenosine 5'-triphosphate(ATP)-binding cassette(ABC)transporter,IrtAB,plays a vital role in the replication and viability of Mycobacterium tuberculosis(Mtb),where its function is to import iron-loaded siderophores...
The CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-028).
We reported herein the synthesis and antibacterial activity evaluation of two oxazolidinone-deferasirox conjugates with different linkers that were designed based on the“Trojan horse”strategy.The conjugates could co...
supported by grants from the Beijing Key Clinical Specialty Funding(No. 010071);Clinical Cohort Construction Program of Peking University Third Hospital(No. BYSYDL2019007);Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities(No. PKU2022LCXQ009)
Iron is an essential trace element for both humans and bacteria.It plays a vital role in life,such as in redox reactions and electron transport.Strict regulatory mechanisms are necessary to maintain iron homeostasis b...
This work was supported scientifically by COST Action ESI406“Soil fauna-Key to Soil Organic Matter Dynamics and Modelling(KEYSOM)”.
Salinity is one of the most important growth-limiting factors for most crops in arid and semi-arid regions;however,the use of plant growth-promoting rhizobacteria isolated from saline soils could reduce the effects of...