A zero-sum game or an interactive frame?Iron competition between bacteriaand humans ininfectionwar  

作　　者：Zhenchao Wu Jiqi Shao Jiajia Zheng Beibei Liu Zhiyuan Li Ning Shen 

机构地区：[1]Department of Pulmonary and Critical Care Medicine,Peking University Third Hospital,Bejing 100191,China [2]Center for Infectious Diseases,Peking University Third Hospital,Bejing 100191,China [3]Center for Quantitative Biology,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China [4]Department of Laboratory Medicine,Peking University Third Hospital,Bejing 100191,China.

出　　处：《Chinese Medical Journal》2022年第16期1917-1926,共10页中华医学杂志（英文版）

基　　金：supported by grants from the Beijing Key Clinical Specialty Funding(No. 010071);Clinical Cohort Construction Program of Peking University Third Hospital(No. BYSYDL2019007);Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities(No. PKU2022LCXQ009)

摘　　要：Iron is an essential trace element for both humans and bacteria.It plays a vital role in life,such as in redox reactions and electron transport.Strict regulatory mechanisms are necessary to maintain iron homeostasis because both excess and insufficient iron are harmful to life.Competition for iron is a war between humans and bacteria.To grow,reproduce,colonize,and successfully cause infection,pathogens have evolved various mechanisms for iron uptake from humans,principally Fe^(3+)-siderophore and Fe^(2+)-heme transport systems.Humans have many innate immune mechanisms that regulate the distribution of iron and inhibit bacterial iron uptake to help resist bacterial invasion and colonization.Meanwhile,researchers have invented detection test strips and coupled antibiotics with siderophores to create tools that take advantage of this battle for iron,to help eliminate pathogens.In this review,we summarize bacterial and human iron metabolism,competition for iron between humans and bacteria,siderophore sensors,antibiotics coupled with siderophores,and related phenomena.We also discuss how competition for iron can be used for diagnosis and treatment of infection inthefuture.

关 键 词：INFECTION Iron metabolism BACTERIA SIDEROPHORE Antibiotic 

分 类 号：R37[医药卫生—病原生物学]