Nobachelins,new siderophores from Nocardiopsis baichengensis protecting Caenorhabditis elegans from Pseudomonas aeruginosa infection  

作　　者：Haowen Zhao Yuhao Ren Feng Xie Huanqin Dai Hongwei Liu Chengzhang Fu Rolf Müller 

机构地区：[1]Helmholtz Institute for Pharmaceutical Research Saarland(HIPS),Helmholtz Centre for Infection Research(HZI),and Department of Pharmacy,Saarland University,66123,Saarbrücken,Germany [2]Helmholtz International Lab for Anti-Infectives,Helmholtz Center for Infection Research,38124,Braunschweig,Germany [3]Institute of Marine Biology and Pharmacology,Ocean College,Zhejiang University,316021,Zhoushan,China [4]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zuchongzhi Road,201203,Shanghai,China [5]State Key Lab of Mycology,Institute of Microbiology,Chinese Academy of Sciences,100101,Beijing,China

出　　处：《Synthetic and Systems Biotechnology》2023年第4期640-646,共7页合成和系统生物技术（英文）

基　　金：support from the Helmholtz International Lab(InterLabs0007);Yuhao Ren acknowledges the support from the International Postdoctoral Exchange Fellowship Program(ZD202125)between Helmholtz Association;Germany and the Office of China Postdoc Council(OCPC),China.

摘　　要：The biosynthetic potential of actinobacteria to produce novel natural products is still regarded as immense.In this paper,we correlated a cryptic biosynthetic gene cluster to chemical molecules by genome mining and chemical analyses,leading to the discovery of a new group of catecholate-hydroxamate siderophores,nobachelins,from Nocardiopsis baichengensis DSM 44845.Nobachelin biosynthesis genes are conserved in several bacteria from the family Nocardiopsidaceae.Structurally,nobachelins feature fatty-acylated hydroxy-ornithine and a rare chlorinated catecholate group.Intriguingly,nobachelins rescued Caenorhabditis elegans from Pseudomonas aeruginosa-mediated killing.

关 键 词：NOCARDIOPSIS Genome mining SIDEROPHORE Pseudomonas aeruginosa INFECTION 

分 类 号：Q93[生物学—微生物学]