β-cyclopiazonic acid binds iron demonstrating siderophorelike activity and promotes growth in Pseudomonas aeruginosa  

作　　者：Yuqi GUO Youmin YING Qihao WU Bin WEI Jianwei CHEN Hong WANG 

机构地区：[1]College of Pharmaceutical Science&Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Journal of Oceanology and Limnology》2023年第3期1159-1167,共9页海洋湖沼学报（英文）

基　　金：Supported by the Natural Foundation of Zhejiang Province(No.LGF21H300003);the Key Laboratory of Tropical Marine Ecosystem and Bioresource,Ministry of Natural Resources(No.2021QN03);the Key Research and Development Program of Zhejiang Province(No.2021C03084);the Key Research and Development Program of National Key R&D Program of China(Nos.2018YFC0311003,2017YFE0103100);the High Level Talent Special Support Plan of Zhejiang Province(No.2019R52009).We also gratefully acknowledge platform support from Zhejiang International Sci-Tech Cooperation Base for the Exploitation and Utilization of Nature Product。

摘　　要：This chemical study reports a novel siderophore-like compound,β-cyclopiazonic acid(1,β-CPA)extracted from marine fungus Aspergillus flavus.The chemical structure ofβ-CPA was elucidated by a combination of extensive spectroscopic analyses and TDDFT-ECD calculations.The iron-binding ability and CAS assays demonstrate thatβ-CPA is a novel siderophore that features a different chemical structure from those of traditional siderophores.Theβ-CPA has no obvious influence on the growth of bacterium Pseudomonas aeruginosa PAO1.However,its iron chelator could promote the growth of P.aeruginosa PAO1,suggesting that P.aeruginosa employed siderophores to sequester iron,which is vital for their survival.The study provides the physiochemical evaluation ofβ-CPA,an unusual skeletonstructure siderophore,which for the first time,was proven to have the ability to bind iron and affect P.aeruginosa growth.This new discovery of siderophore provides an opportunity for developing novel anti-P.aeruginosa drugs.

关 键 词：marine fungi β-cyclopiazonic acid SIDEROPHORE Pseudomonas aeruginosa 

分 类 号：R914[医药卫生—药物化学]