BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and cornea.Diagnoses and treatments are challenging in settings,where advanced diagnostic tests are unav...
Background: Diabetes insipidus (DI) is a rare disorder characterized by inappropriate polyuria and hypo-osmolar urine. It is caused by inadequate production of antidiuretic hormone, in response to hypothalamic osmorec...
Wilson disease is an autosomal recessive disorder affecting the ATP7B gene located on chromosome 13q.This leads to copper deposition in various organs,most importantly in the liver and brain.The genetic mutations are ...
supported by the National Science Fund for Distinguished Young Scholars(No.22125101).
The ring-opening polymerization of heterocyclic monomers and the reversed ring-closing depolymerization of corresponding polymers with neutral thermodynamics are broadly explored to establish a circular economy of nex...
Wilson’s disease(WD)is a rare inherited disorder of human copper metabolism,with an estimated prevalence of 1:30000-1:50000 and a broad spectrum of hepatic and neuropsychiatric manifestations.In healthy individuals,t...
Chelation is the mainstay of therapy in certain pediatric liver diseases.Copper and iron related disorders require chelation.Wilson’s disease(WD),one of the common causes of cirrhosis in children is treated primarily...
financially supported by the Huaibei Normal University Doctoral Research Start-up Funding(No.15601012);the Natural Science Foundation of Anhui Provincial Department of Education(No.KJ2019A0598);the Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province,China(No.gxyq2019168);the Team of Superior Discipline of Chemistry(No.GFXK202108).
Synthesizing atomically precise Ag nanoclusters(NCs),which is essential for the general development of NCs,is quite challenging.In this study,we report the synthesis of high-purity atomically precise Ag NCs via a kine...
BACKGROUND Acute liver failure(ALF)can be a primary presentation of Wilson disease(WD).Mortality rates are high in WD with ALF(WDALF).Predictions of mortality in WDALF vary by model and are sometimes contradictory,per...
Using B3LYP and M06-2X functionals,eight noncovalent configurations for the adsorption of D-penicillamine drug(DPA)drug on poly(amidoamine)G0 generation dendrimer(PAMAMG0)carrier have been investigated.The quantum mol...
Supported by National Natural Science Foundation of China:Study on the Effect of Gandou Tablets in Mitophagy by Willson Disease Model TX Mouse(No.81503443)
OBJECTIVE: To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson's disease (WD) who have neurological symptoms. METHODS: WD patients with neurological ...