云南高校图书馆联盟文献共享服务平台- HIF-1A

HIF-1A: 作品数：112被引量：430H指数：12; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：谢明星贺延玉黄晓宇李鹏飞武彧更多>>; 相关机构：河北医科大学哈尔滨医科大学郑州大学福建医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金安徽省教育厅重点科研项目辽宁省教育厅科学基金湖南省卫生厅科研基金更多>>

Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway: 《Chinese Journal of Natural Medicines》2025年第3期299-310,共12页Zhengrong Li Yuwen Liu Kedi Liu Xingru Tao Naping Hu Wangting Li Jialin Duan; supported by the National Science Foundation of China(No.81903832),the Key Research and Development Plan of Shaanxi Province(No.2022SF-182),the Fundamental Research Funds for the Central Universities(No.D5000210799);Shaanxi Provincial Traditional Chinese Medicine Administration"Double Chain Integration"Middle Youth Research and Innovation Team Project(No.2022-SLRH-LJ-007);Shanghai Science and Technology Innovation Action Plan(No.22S21902600).; Aralia taibaiensi,widely distributed in western China,particularly in the Qinba Mountains,has been utilized as a folk medicine for treating diabetes,gastropathy,rheumatism,and cardiovascular diseases.Saponins from A.t...; 关键词：Aralia taibaiensis Apelin/apelin receptor Stroke P38 MAPK/ATF4 HIF-1A

低氧诱导因子HIF-1A调控GLUT3表达促进胶质瘤增殖的影响: 《海南医科大学学报》2025年第2期81-86,共6页陈泰学羊良旺陈申波高振忠李争争王艳刘晓召杨堃; 海南省卫生健康行业科研项目(21A200080);国家自然科学基金资助项目(82060456);海南省“南海新星”科技创新人才平台项目(NHXXRCXM202351)。; 目的:探讨乏氧环境下HIF-1A对胶质瘤GLUT3表达的影响及其机制。方法:CGGA数据库分析HIF-1A与GLUT3表达相关性及其对预后影响;CoCL2诱导胶质瘤细胞乏氧环境,Western blotting检测U251与U87细胞中GLUT3基因表达变化;Western blotting检测...; 关键词：胶质瘤氧诱导因子葡萄糖转运酶3 细胞增殖

温阳化浊通络方体外抑制HIF-1a/Foxm1/smad3信号通路改善系统性硬化病肺微血管损伤: 《中国药理学通报》2024年第11期2119-2123,共5页卞博苗青吴范武范艺龄孔金莉卞华李凯; 国家自然科学基金面上项目(No 82074415);中原科技创新领军人才项目(No 234200510006)。; 目的利用系统性硬化病(systemic sclerosis,SSc)肺微血管内皮细胞缺氧模型,研究温阳化浊通络方抑制内皮细胞的内皮-间充质转化(EndoMT)改善肺微血管损伤的分子机制。方法利用SSc患者血清培养正常人肺微血管内皮细胞构建SSc肺微血管内皮...; 关键词：温阳化浊通络方内皮-间充质转化系统性硬化病缺氧肺微血管损伤 HIF-1a/Foxm1/smad3通路

多发性骨髓瘤硼替佐米耐药患者骨髓CD138浆细胞中HIF-1a、PG-p的表达意义分析: 《中文科技期刊数据库(全文版)医药卫生》2024年第8期029-032,共4页古再丽努尔·吾甫尔赵佳琳黄琴李燕; 新疆少数民族科技人才特殊培养计划科研项目,项目名称:HIF-1a诱导P-gp对多发性骨髓瘤硼替佐米耐药的机制研究,项目编号:2021D03021。; 探讨多发性骨髓瘤硼替佐米耐药患者骨髓CD138 浆细胞中HIF-1a、PG-p的表达意义。方法收集新疆维吾尔自治区人民医院2020年1月至 2023年8月收治确诊为硼替佐米敏感、耐药多发性骨髓瘤患者各30例,收集其骨髓标本。收集两组患者的病理资料...; 关键词：多发性骨髓瘤硼替佐米耐药 CD138浆细胞 HIF-1a表达水平 PG-p表达水平

Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis被引量：1: 《Acta Pharmaceutica Sinica B》2024年第8期3591-3604,共14页Juan Rong Chenxia Han Yan Huang Yiqin Wang Qi Qiu Manjiangcuo Wang Shisheng Wang Rui Wang Juqin Yang Xia Li Chenggong Hu Zhiyao Chen Lihui Deng Wei Huang Qing Xi Dan Du; supported by the National Natural Science Foundation of China(Dan Du,82170905);the Program of Science and Technology Department of Sichuan Province(Dan Du,2023NSFSC1755,China);the State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College(Dan Du,GTZK202107,China);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Qing Xia,ZYJC18005,China);the West China,Nursing Discipline Development Special Fund Project,Sichuan University(Xia Li,HXHL21060,China).; Acute pancreatitis(AP)is a potentially fatal condition with no targeted treatment options.Although inhibiting xanthine oxidase(XO)in the treatment of AP has been studied in several experimental models and clinical tri...; 关键词：Xanthine oxidase inhibitor Multi-omics HIF-1A Necrotizing acute pancreatitis LACTATE Therapeutic target NLRP3 Metabolic flux

Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway被引量：1: 《Acta Pharmacologica Sinica》2024年第7期1520-1529,共10页Qi Su Jing-jing Wang Jia-yan Ren Qing Wu Kun Chen Kai-hui Tu Yu Zhang Sze Wei Leong Ammar Sarwar Xu Han Mi Zhang Wei-feng Dai Yan-min Zhang; supported by the National Natural Science Foundation of China (Grant 81903643 and 82374095);the National Natural Science Foundation of Shaanxi Province (2024JC-YBQN-0891);the Shaanxi Province Science Fund for Distinguished Young Scholars (2023-JC-JQ-59);the Shaanxi Province Science and Technology Development Plan Project (2022ZDLSF05-05).; Parkin(PARK2)deficiency is frequently observed in various cancers and potentially promotes tumor progression.Here,we showed that Parkin expression is downregulated in liver cancer tissues,which correlates with poor pa...; 关键词：PARKIN TMEFF1 TGF-β/Smad2/3 transcription activation HIF-1a/HIF-1β p53

力学拉伸通过STAT3/HIF-1a/PDK1轴介导角膜成纤维细胞糖酵解相关酶的表达: 《医用生物力学》2024年第S01期443-443,共1页冯鹏飞赵鹏枭宋婕马晓璐李晓娜陈维毅; 国家自然科学基金项目,12002233,11872262,12072218;山西省自然科学基金项目,20210302123096,202203021211155; 目的圆锥角膜是眼科临床常见的致盲疾病,具体发病机制尚不完全清楚,其中力学微环境变化不可忽略。研究表明圆锥角膜的发生可能和细胞能量代谢异常有关。探讨力学刺激对角膜成纤维细胞糖酵解相关酶表达的影响及其调控途径,可为深入理解...; 关键词：圆锥角膜力学刺激 GLUT1 STAT3 角膜成纤维细胞糖酵解相关酶眼科临床

血清β-arrestin 2、HIF-1a及CA125联合预测慢性乙型肝炎肝纤维化的价值: 《肝脏》2024年第5期521-525,共5页汪蕾陈晨华喜梅胡丰芬; 江苏省科技厅社会发展重点项目(BE2019638)。; 目的探讨血清β-抑制蛋白2(β-arrestin2)、缺氧诱导因子1a(hypoxia inducible factor1α,HIF-1a)及糖类抗原125(carbohydrate antigen 125,CA125)联合预测慢性乙型肝炎(chronic Hepatitis B,CHB)肝纤维化的价值。方法选择宿迁市第一人...; 关键词：血清β-抑制蛋白2 缺氧诱导因子1A 糖类抗原125 慢性乙型肝炎肝纤维化

Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice: 《Journal of Pharmaceutical Analysis》2024年第5期678-692,共15页Ting Gao Yixuan Li Xiaoyu Wang Fazheng Ren; The“gut-skin”axis has been proved and is considered as a novel therapy for the prevention of skin aging.The antioxidant efficacy of oligomannonic acid(MAOS)makes it an intriguing target for use to improve skin aging...; 关键词：Alginate oligosaccharide Skin aging BUTYRATE HIF-1A MITOPHAGY

NAD^(+) salvage governs the immunosuppressive capacity of mesenchymal stem cells被引量：1: 《Cellular & Molecular Immunology》2023年第10期1171-1185,共15页Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi; supported by grants from the National Key R&D Program of China(2021YFA1100600 and 2022YFA0807300);the National Natural Science Foundation of China(82202032,81930085 and 32150710523);the Jiangsu Province International Joint Laboratory for Regenerative Medicine Fund and the Suzhou Foreign Academician Workstation Fund(SWY202202).; Mesenchymal stem/stromal cells(MSCs)possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders.This capacity is not innate but is activated or‘licensed’by inflammatory cytoki...; 关键词：Mesenchymal stem/stromal cells NAD^(+)metabolism IMMUNOMODULATION Glycolysis HIF-1A SUCCINATE

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