Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice  

作　　者：Ting Gao Yixuan Li Xiaoyu Wang Fazheng Ren 

机构地区：[1]Department of Nutrition and Health,College of Veterinary Medicine,China Agricultural University,Beijing,100083,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第5期678-692,共15页药物分析学报（英文版）

摘　　要：The“gut-skin”axis has been proved and is considered as a novel therapy for the prevention of skin aging.The antioxidant efficacy of oligomannonic acid(MAOS)makes it an intriguing target for use to improve skin aging.The present study further explored whereby MAOS-mediated gut-skin axis balance prevented skin aging in mice.The data indicated the skin aging phenotypes,oxidative stress,skin mitochondrial dysfunction,and intestinal dysbiosis(especially the butyrate and HIF-1a levels decreased)in aging mice.Similarly,fecal microbiota transplantation(FMT)from aging mice rebuild the aging-like phenotypes.Further,we demonstrated MAOS-mediated colonic butyrate-HIF-1a axis homeostasis promoted the entry of butyrate into the skin,upregulated mitophagy level and ultimately improving skin aging via HDAC3/PHD/HIF-1a/mitophagy loop in skin of mice.Overall,our study offered a better insights of the effectiveness of alginate oligosaccharides(AOS),promised to become a personalized targeted therapeutic agents,on gut-skin axis disorder inducing skin aging.

关 键 词：Alginate oligosaccharide Skin aging BUTYRATE HIF-1A MITOPHAGY 

分 类 号：R283.6[医药卫生—中药学]