Antioxidant activity of the thioredoxin system  

作　　者：Zihua Liu 

机构地区：[1]Department of blood transfusion school of second hospital,Lanzhou University,Lanzhou 730030,China

出　　处：《Biophysics Reports》2023年第1期26-32,共7页生物物理学报（英文版）

基　　金：supported by the Cuiying Science and technology Innovation Project(CY2021-MS-B07);Cuiying students'scientific research and cultivation program(CYXZ2020-34);Natural Science Foundation of Gansu Province(22JR5RA987).

摘　　要：The thioredoxin system is composed of thioredoxin(Trx),thioredoxin reductase(TR)and reduced nicotinamide adenine dinucleotide phosphate.Trx is an important antioxidant molecule that can resist cell death caused by various stresses and plays a prominent role in redox reactions.TR is a protein that contains selenium(selenocysteine),in three main forms,namely,TR1,TR2 and TR3.TR1,TR2 and TR3 are mainly distributed in the cytoplasm,mitochondria,and testes,respectively.TR can regulate cell growth and apoptosis.After a cell becomes cancerous,the expression of TR is increased to promote cell growth and metastasis.The Trx system is closely related to neurodegenerative diseases,parasitic infec-tions,acquired immunodeficiency syndrome,rheumatoid arthritis,hypertension,myocarditis,and so on.In addition,the Trx system can remove the reactive oxygen species in the body and keep the inside and outside of the cell in a balanced state.In summary,the Trx system is an important target for the drug treatment of many diseases.

关 键 词：THIOREDOXIN Thioredoxin reductase CANCER Neurodegenerative disease 

分 类 号：R36[医药卫生—病理学]