ALANTOLACTONE

作品数：7被引量：5H指数：1
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相关领域：医药卫生更多>>
相关作者：刘子裕王强林张新国寇飞更多>>
相关机构：大连医科大学兰州理工大学更多>>
相关期刊：《Asian Journal of Pharmaceutical Sciences》《Journal of Chinese Pharmaceutical Sciences》《Chemical Research in Chinese Universities》《Genes & Diseases》更多>>
相关基金：国家自然科学基金更多>>
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AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer
《Acta Pharmaceutica Sinica B》2024年第12期5305-5320,共16页Zhiwen Fu Tingting Wu Chen Gao Lulu Wang Yu Zhang Chen Shi 
supported by the National Natural Science Foundation of China(Grant Nos.82204758 and 82073402).
Oxaliplatin(OXA),a platinum-based chemotherapeutic agent,remains a mainstay in first-line treatments for advanced colorectal cancer(CRC).However,the eventual development of OXA resis-tance represents a significant cli...
关键词：Oxaliplatin resistance AKR1C1 Colorectal cancer ALANTOLACTONE GLUTATHIONE Combination therapy Natural product CHEMORESISTANCE 
Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]
《Genes & Diseases》2023年第2期620-623,共4页Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo 
Alantolactone inhibits proliferation,metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways被引量：3
《Genes & Diseases》2022年第2期466-478,共13页Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo 
The present research was supported by the National Natural Science Foundation of China(No.81874001);the Natural Science Foundation Project of Chongqing Science and Technology Commission(No.cstc2017jcyjAX0196).
Although there are many therapeutic strategies such as surgery and chemotherapy,the prognosis of osteosarcoma(OS)is still far from being satisfactory.It is urgent to develop more effective,tolerable and safe drugs for...
关键词：ALANTOLACTONE ERK1/2 JNK Mitogen activated protein kinases OSTEOSARCOMA p38 WNT/Β-CATENIN 
Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment被引量：1
《Asian Journal of Pharmaceutical Sciences》2022年第2期268-283,共16页Ruijie Chen Yuan-Yuan Zhai Lining Sun Zeqing Wang Xing Xia Qing Yao Longfa Kou 
inancially supported by the National Natural Science Foundation of China (81903551);Zhejiang Province Natural Science Foundation (LQ19H300001);Excellent Young Scientist Training Program fund from Wenzhou Medical University
Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes and massive infiltration of inflammatory immune cells.Recent studies showed ...
关键词：PSORIASIS ALANTOLACTONE STAT3 CHITOSAN NANOPARTICLE 
Study on alantolactone-induced differentiation of mesenchymal stem cells intovascular cells被引量：1
《Traditional Medicine Research》2018年第4期181-190,共10页Yan-Jiao Lu Qiong Lu Ruo-Ke Su GangWang Rui Tan 
To promote efficient screening of active angiogenic drugs from traditional medicines, we constructed a humanembryonic kidney-293 cell model using vascular endothelial growth factor （VEGF） gene promoter as the drug t...
关键词：Alanlactone ANGIOGENESIS Stably transformed cell line rMSCs VEGF Α-SMA 
Bioavailability and pharmacokinetics of alantolactone from Inula helenium in rats following intravenous and oral administrations
《Journal of Chinese Pharmaceutical Sciences》2017年第4期284-290,共7页张新国 刘琎文 寇飞 王强林 刘子裕 李建勇 
The National Natural Science fund of China(Grant No.31360379);the open fund of the Key Laboratory of the New Animal Drug Project of Gansu Province;the Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture(Grant No.2014)
Alantolactone, as the principal constituent oflnula Helenium L, has been shown various pharmacologic activities, such as anti-inflammatory and deworming. In the present study, we developed a high performance liquid ch...
关键词：HPLC ALANTOLACTONE PHARMACOKINETIC BIOAVAILABILITY 
Inhibitory Effects of Natural Compound Alantolactone on Human Non-small Cell Lung Cancer A549 Cells
《Chemical Research in Chinese Universities》2011年第2期241-244,共4页ZONG Min-ru ZHAO Ying-hao ZHANG Kun YANG Long-fei ZHENG Yong-chen HE Cheng-yan 
Supported by the Natural Science Foundation of Jilin Province; China(No.20090461)
Alantolactone is a natural compound identified from the roots of Inula helenium L. that has multiple bio-activities. We examined its inhibitory effects on human non-small cell lung cancer（NSCLC） A549 cells. The an-t...
关键词：ALANTOLACTONE Non-small cell lung cancer（NSCLC） A549 PROLIFERATION APOPTOSIS 
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