MITOXANTRONE

作品数：26被引量：35H指数：3
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相关领域：医药卫生更多>>
相关作者：张志荣廖工铁鲍慧铮丛琦程颖更多>>
相关机构：华西医科大学吉林省肿瘤医院第二军医大学山西医科大学更多>>
相关期刊：《实用肿瘤学杂志》《Journal of Hainan Medical University》《Journal of Chinese Pharmaceutical Sciences》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划吉林省科技发展计划基金天津市自然科学基金更多>>
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Sodium cholesterol sulfate mediated mitoxantrone prodrug electrostatic nanocomplexes:achieving the therapeutic efficacy and safety of mitoxantrone
《Science China Chemistry》2025年第3期1185-1198,共14页Erwei Zhao Lingxiao Li Jingyi Zhang Yaqiao Li Rong Chai Bowen Zhang Jialin Xing Minglong Huang Lurong Zhang Xiaohui Pu Zhonggui He Bingjun Sun 
financial support from National Natural Science Foundation of China (82272151,82173766,and 82204318);Liaoning Revitalization Talents Program (XLYC2203083);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program (RC220389)。
Forming electrostatic nanocomplexes(ENCs)with counter-ions can improve the delivery efficiency of chemotherapy drugs.However,water-soluble chemotherapy drugs like mitoxantrone(MTO),have limited affinity for counter-io...
关键词：MITOXANTRONE PRODRUG sodium cholesterol sulfate electrostatic nanocomplexes disulfide bond 
Catalytic detoxification of mitoxantrone by graphitic carbon nitride(g-C_(3)N_(4))supported Fe/Pd bimetallic nanoparticles
《Journal of Environmental Sciences》2025年第2期614-624,共11页Qianyu Xu Haoyang Fu Jiyuan Gu Liyu Lei Lan Ling 
Financial support from the National Natural Science Foundation of China (No.22176147);the National Science Fund for Excellent Young Scholars of China (No.21822607);the Fundamental Research Funds for Central Universities (No.22120230295);the State Key Laboratory for Pollution Control is acknowledged.
The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effecti...
关键词：DEGRADATION LC-QTOF-MS Nanoparticles MITOXANTRONE Aqueous solution 
The Applications of Mitoxantrone and Its Liposome in Adult Acute Myeloid Leukemia
《Open Journal of Blood Diseases》2023年第1期51-58,共8页Guancheng Song Jiaqi Gu Ying Chen Yanfang Zhang Xi Huang Shifeng Lou Jianchuan Deng 
Acute myeloid leukemia (AML), a rapidly progressing hematopoietic malignancy, can only be cured hopefully by hematopoietic stem cells transplantation (HSCT). Before HSCT, we usually exert effects by attempting certain...
关键词：Acute Myeloid Leukemia Liposomal Mitoxantrone TOXICITY ANTHRACYCLINES 
A tactical nanomissile mobilizing antitumor immunity enables neoadjuvant chemo-immunotherapy to minimize postsurgical tumor metastasis and recurrence被引量：1
《Acta Pharmaceutica Sinica B》2023年第2期804-818,共15页Tao He Mingxing Hu Shunyao Zhu Meiling Shen Xiaorong Kou Xiuqi Liang Lu Li Xinchao Li Miaomiao Zhang Qinjie Wu Changyang Gong 
financially supported by the National Natural Science Foundation of China(82172094);Funds of Sichuan Province for Distinguished Young Scholar(2021JDJQ0037,China);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYYC08002,China)。
Neoadjuvant chemotherapy has become an indispensable weapon against high-risk resectable cancers,which benefits from tumor downstaging.However,the utility of chemotherapeutics alone as a neoadjuvant agent is incapable...
关键词：NEOADJUVANT Chemotherapy Immunotherapy MITOXANTRONE Vaccine Azobenzene derivatives Reduction responsive MELANOMA 
Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions
《Chinese Chemical Letters》2021年第3期1220-1223,共4页Hangqi Zhu Bing Zhang Nali Zhu Mingchun Li Qilin Yu 
supported by National Natural Science Foundation of China(No.31870139);Natural Science Foundation of Tianjin(No.19JCZDJC33800);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-006);the Fundamental Research for the Central Universities。
In this study,we prepared mitochondrion targeting peptide-grafted magnetic graphene oxide(GO)nanocarriers for efficient impairment of the tumor mitochondria.The two-dimensional GOMNP-MitP nanosheets were synthesized b...
关键词：Magnetic graphene oxide Nanocarrier Mitochondrion-targeting peptide MITOXANTRONE Cancer therapy 
Interactions of Mitoxantrone-Modified Superparamagnetic Iron Oxide Nanoparticles with Biomimetic Membranes and Cells
《材料科学与工程（中英文B版）》2020年第1期34-48,共15页Dorota Nieciecka Krystyna Kijewska Stephen M.Baumler Anna K.Puszko Aleksandra Misicka Gary J.Blanchard Pawel Krysinski 
This work was supported by a Project Sonata(2016/23/D/ST4/03212);Project Opus(UMO-2016/21/B/ST4/02133)from National Science Centre(NCN).
We report on the formation of conjugates of superparamagnetic iron nanoparticles(NPs)with the chemotherapeutic agent mitroxantrone(MTX).The NPs are synthesized from mixed iron oxides and are ca.15 nm in diameter.Decor...
关键词：Biomimetic membranes magnetic nanoparticles MITOXANTRONE Langmuir-Blodgett technique 
Effects of pirarubicin and mitoxantrone for bladder cancer perfusion chemotherapy on the expression of malignant molecules in serum and lavage fluid
《Journal of Hainan Medical University》2018年第12期50-53,共4页Wei Jiang Ming Fu 
Project of Hubei Provincial Natural Science Foundation ,No:(2012)30.
Objective: To study the effects of pirarubicin and mitoxantrone for bladder cancer perfusion chemotherapy on the expression of malignant molecules in serum and lavage fluid. Methods:Patients with advanced bladder canc...
关键词：BLADDER cancer PIRARUBICIN MITOXANTRONE Proliferation Invasion 
Comparison of Mitoxantrone in Combination with Intermediate-dose Cytarabine versus High-dose Cytarabine as Consolidation Therapies for Young Non-APL Acute Myeloid Leukemia Patients with Favorable and Intermediate Cytogenetics被引量：2
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2018年第1期51-57,共7页Ji-hao ZHOU Hai-qing LIN Qi SHEN Li-na HU Guo-qiang LI Xiong-fei SUN Xin-you ZHANG 
supported by grants from the Basic Research Project of Shenzhen Science and Technology Program(No.JYCJ20150403101146307,No.JCYJ20150403101028195 and No.JCYJ20160422145031770);the National Natural Science Foundation of China(No.81600168)
In this study,we compared the efficacy of mitoxantrone in combination with intermediate-dose cytarabine（HAM） with that of high-dose cytarabine alone（Hi DAC） as consolidation regimens in non-acute promyelocytic leu...
关键词：CYTARABINE MITOXANTRONE CONSOLIDATION acute myeloid leukemia CYTOGENETICS 
Preparation and functional characterization of tumor-targeted folic acid-chitosan conjugated nanoparticles loaded with mitoxantrone被引量：2
《Journal of Central South University》2015年第9期3311-3317,共7页王炜 童春义 刘星言 李涛 刘斌 熊炜 
Projects(31201074,81371013) supported by the National Natural Science Foundation of China;Project(2011105102016) supported by the Key Program of Medical Health of Dongguan City,Guangdong Province,China;Project(2011108102026) supported by Dongguan Universities Program,China
Folic acid conjugated chitosan was prepared by cross-linking reaction with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride(EDC), and then used as a template to prepare folic acid-chitosan(FA-CS) conjugate...
关键词：folic acid CHITOSAN NANOPARTICLES MITOXANTRONE tumor targeting 
Silencing the expression and function of breast cancer resistance protein in MCF-7/MX100 cells by shRNA expressing lentivirus
《Journal of Chinese Pharmaceutical Sciences》2014年第11期743-750,共8页余彩虹 徐思云 喻爱明 刘彦卿 胡海红 李丽萍 余露山 周慧 蒋惠娣 曾苏 
National Major Projects of the Ministry of Science and Technology of China (Grant No.2012ZX09506001-004)
Overexpression of breast cancer resistance protein （ABCG2/BCRP） in cancer cells may cause tumor resistance to chemotherapeutic drugs. RNA interference （RNAi） can selectively silence the expression of a target gene...
关键词：BCRP RNA interference Lentiviral expression system Drug resistance reversal MITOXANTRONE TCM 
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