CYTARABINE

作品数：32被引量：47H指数：3
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相关领域：医药卫生更多>>
相关机构：北海道药科大学浙江大学医学院附属第一医院更多>>
相关期刊：《World Journal of Clinical Cases》《Asian Journal of Pharmaceutical Sciences》《World Journal of Clinical Oncology》《解放军医药杂志》更多>>
相关基金：国家自然科学基金更多>>
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AHR signaling pathway mediates mitochondrial oxidative phosphorylation which leads to cytarabine resistance
《Acta Biochimica et Biophysica Sinica》2024年第4期597-606,共10页Yan Jia Xiyu LI Lulu Chen Ling Li Suzhen zhang Wenhui Huang Hao Zhang 
supported by the grants from the Youth Program of the Natural Science Foundation of Shangdong Province(No.ZR2022QH239);PhD Research Foundation of Affiliated Hospital of Jining Medical University(2022-BS-007);the“Nursery”Research Program of Affiliated Hospital of Jining Medical University(MP-ZD-2021-004).
The aryl hydrocarbon receptor(AHR)has been identified as a significant driver of tumorigenesis.However,its clinical significance in acute myeloid leukemia(AML)remains largely unclear.In this study,RNA-Seq data from AM...
关键词：AHR expression AML mitochondrial oxidative phosphorylation cytarabine resistance 
Clinical characteristics of delayed generalized erythema associated with cytarabine
《Chronic Diseases and Translational Medicine》2024年第1期78-80,共3页He Jiang Jun Lu Mei Wang 
The Foundation of GUSU Health Talent Research Project(Grant/Award Number:GSW2022057);the Key Technology Research and Development Project for Medical and Health Technology Innovation of Soochow(Grant/Award Number:SKY2021049).
To the Editor,Cytarabine is one of the most used drugs for the treatment of hematological malignancies such as leukemia and non-Hodgkin's lymphoma.In cells,cytarabine is activated into ara-CTP,which can replace deoxyc...
关键词：DEATH DRUGS CLINICAL 
Medium‑cumulative dose of cytarabine in consolidation therapy shows the greatest benefit in AML patients
《Holistic Integrative Oncology》2024年第1期489-500,共12页Yiping Hao Min Ji Shumin Jin Wei Li Ying Zhou Ruinan Jia Wěi Li Huihui Jiang Jingtao Wang Fei Lu Shaolei Zang Chunqing Zhang Jingjing Ye Chunyan Ji 
Background High-dose cytarabine(HDAC)is commonly used for consolidation therapy in young acute myeloid leukemia(AML)patients,but the dosage of cytarabine is still controversial in the clinic due to its obvious post-ch...
关键词：Acute myeloid leukemia CYTARABINE Consolidation chemotherapy Survival analysis 
Chidamide,Decitabine,Cytarabine,Aclarubicin,and Granulocyte Colony-stimulating Factor Therapy for Patients with Relapsed/Refractory Acute Myeloid Leukemia:A Retrospective Study from a Single-Center
《Current Medical Science》2023年第6期1151-1161,共11页Fan-cong KONG Ling QI Yu-lan ZHOU Min YU Wen-feng HUANG Fei LI 
the National Natural Science Foundation of China(No.81960043 and No.81600180);Natural Science Foundation of Jiangxi Province(No.20192ACB20030 and No.20203BBGL73197);Science and Technology Innovation Base Construction Project of Jiangxi Province(No.20212BCG74001 and No.20211ZDG02006).
Objective Preclinical evidence and clinical trials have suggested synergistic effects of epigenetic modifiers in combination with cytotoxic agents for the treatment of leukemia.However,their efficacy in patients with ...
关键词：relapsed/refractory acute myeloid leukemia histone deacetylase inhibitor DNA methyltransferase inhibitor salvage therapy 
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway被引量：1
《Acta Pharmacologica Sinica》2023年第11期2296-2306,共11页Han-lin Wang Jia-nan Li Wei-juan Kan Gao-ya Xu Guang-hao Luo Ning Song Wen-biao Wu Bo Feng Jing-feng Fu Yu-tong Tu Min-min Liu Ran Xu Yu-bo Zhou Gang Wei Jia Li 
supported by National Natural Science Foundation of China(81821005);Guangdong High-level New R&D Institute(2019B090904008);Guangdong High-level Innovative Research Institute(2021B0909050003);Science and Technology Commission of Shanghai Municipality(18431907100 and 19430750100).
Current therapy for acute myeloid leukemia (AML) is largely hindered by the development of drug resistance of commonly used chemotherapy drugs, including cytarabine, daunorubicin, and idarubicin. In this study, we inv...
关键词：acute myeloid leukemia CYTARABINE DAUNORUBICIN IDARUBICIN drug resistant multi-omics AUTOPHAGY chloroquine phosphate 
Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes被引量：4
《Chinese Chemical Letters》2022年第10期4600-4604,共5页George Frimpong Boafo Yejiao Shi Qingqing Xiao Kosheli Thapar Magar Makhloufi Zoulikha Xuyang Xing Chao Teng Emmanuel Brobbey Xiaotong Li Xiaohong Jiang Xiaochun Wang Yi Yang Samuel Kesse Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823 and 82073782);the Double First-Class(No.CPU2018PZQ13)of the China Pharmaceutical University;the Shanghai Science and Technology Committee(No.19430741500);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(No.zdsys-202103)。
Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubici...
关键词：Breast cancer DAUNORUBICIN CYTARABINE CO-DELIVERY Liposomes 
Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review被引量：2
《Blood Science》2022年第2期93-96,共4页Guangji Zhang Yang Song Li Wan Kaiqi Liu Shaowei Qiu Jianxiang Wang Yingchang Mi 
The authors would like to appreciate the funding of National Key Research and Development Program of China(2019YFC0840605).
Introduction:Acute promyelocytic leukemia(APL)is mostly due to the chromosome translocation t(15;17)(q22;q12),leading to the formation of PML-RARA fusion protein.Some patients carried rare translocation involving RARA...
关键词：Acute promyelocytic leukemia(APL) Case report Nested PCR STAT5b-RARA Venetoclax 
Cytarabine delivered by CD44 and bone targeting redox-sensitive liposomes for treatment of acute myelogenous leukemia被引量：2
《Regenerative Biomaterials》2022年第1期750-760,共11页Hao Wu Yuan Gao Jia Ma Maosong Hu Jing Xia Shuting Bao Yuxi Liu Kai Feng 
supported by the Chuzhou University Scientific Research Fund(2020qd50,2022XJYB10);the Key Research and Development Program of Anhui Province(202104b11020010);the Students’Innovation and Entrepreneurship Training Program of Anhui Province(S202110377140).
Acute myelogenous leukemia(AML)remains a serious fatal disease for the patients and effective treatment strategies are urgently needed.Based on the characteristics of the AML,we developed the CD44 and bone targeting l...
关键词：CYTARABINE liposomes acute myeloid leukemia hyaluronic acid 
Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation被引量：2
《Chinese Medical Journal》2021年第12期1477-1479,共3页Si-Si Chen Qian Sun Lan Cao Wen-Zhong Wu Yue Xie Chun Qiao Jian-yong Li Si-Xuan Qian Ming Hong 
supported by the National Natural Science Foundation of China(Nos.81870119 and 81720108002);the National Science and Technology Major Project(No.2018ZX09734007);the Clinical Medicine and Technological Development Foundation of Jiangsu University(No.JLY20180072).
Tumor suppressor gene P53(TP53)is a critical tumor suppressor gene.The mutant p53 protein enhances the activity,invasion and metastasis of tumor cells.Acute myeloid leukemia(AML)patients with TP53 mutations respond po...
关键词：TP53 PATIENTS stimulating 
AHR signaling pathway reshapes the metabolism of AML/MDS cells and potentially leads to cytarabine resistance被引量：2
《Acta Biochimica et Biophysica Sinica》2021年第4期492-500,共9页Yan Jia Juan Guo Youshan Zhao Zheng Zhang Lei Shi Ying Fang Dong Wu Lingyun Wu Chunkang Chang 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81570108 and 81400090).
Emerging evidence suggests that aryl hydrocarbon receptor(AHR)promotes the initiation,invasion,progression,and metastasis of cancer cells.However,its effects in patients with myelodysplastic syndrome/acute myeloid leu...
关键词：AHR AML MDS mitochondrial metabolism RESISTANCE 
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