supported by National Natural Science Foundation of China(81821005);Guangdong High-level New R&D Institute(2019B090904008);Guangdong High-level Innovative Research Institute(2021B0909050003);Science and Technology Commission of Shanghai Municipality(18431907100 and 19430750100).
Current therapy for acute myeloid leukemia (AML) is largely hindered by the development of drug resistance of commonly used chemotherapy drugs, including cytarabine, daunorubicin, and idarubicin. In this study, we inv...
supported by the National Natural Science Foundation of China(Nos.81872823 and 82073782);the Double First-Class(No.CPU2018PZQ13)of the China Pharmaceutical University;the Shanghai Science and Technology Committee(No.19430741500);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(No.zdsys-202103)。
Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubici...
Aim:To identify a drug that can effectively eliminate these cancer stem cells(CSCs)and determine its mode of action.Methods:CSCs were obtained from mouse induced pluripotent stem cells(miPSCs)using cancer cell-conditi...
Objective:To study the different influence of idarubicin + Arac (IA) therapy and daunorubicin + Arac (DA) therapy on malignant molecule expression of acute myelocytic leukemia. Methods: A total of 56 patients who were...
This work is supported by the Scientific Research General Project of Liaoning Provincial Department of Education(No.L2014388);the Natural Science Foundation of Liaoning Province(No.2015020753);Nature Science Foundation of China(No.81503020,No.31600767).
Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect.The present study outlines the fabrication of daunorubicin hydrochloride-loaded poly (ε-caprolactone)(PCL) fibrous...
National Natural Science Foundation of China(Grant No.81373343);the Key Grant of Beijing Natural Science Foundation(Grant No.7131009)
Triple-negative breast cancer is the tumor that lacks expressions of estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor-2(HER2). A regular chemotherapy cannot eradicate t...
In commenting on a case report of a 55-year-old man who suffered Takotsubo syndrome(TTS), in the setting of receiving chemotherapy with cytarabine and daunorubicin for acute myeloid leukemia, the author expresses his ...
Chemotherapy has been linked with Takotsubo cardiomyopathy. Most of the literature on chemotherapy associated Takotsubo cardiomyopathy is on the drug 5-fluorouracil. In this report, we describe the case of a 55-year-o...
The aim of this study was to investigate whether miR-181a could modulate the sensitivity of the leukemia drug- resistant cell line K562/A02 to the chemotherapeutic agent daunorubicin (DNR), and explore the mechanism...