DAUNORUBICIN

作品数:17被引量:48H指数:4
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相关领域:医药卫生更多>>
相关作者:张强宫蔷赵曜李慧陆华中更多>>
相关机构:北京大学第三军医大学西南医院贵阳医学院附属医院东南大学更多>>
相关期刊:《Journal of Hainan Medical University》《Bioactive Materials》《Journal of Chinese Pharmaceutical Sciences》《眼科学报》更多>>
相关基金:国家自然科学基金国家教育部博士点基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway被引量:1
《Acta Pharmacologica Sinica》2023年第11期2296-2306,共11页Han-lin Wang Jia-nan Li Wei-juan Kan Gao-ya Xu Guang-hao Luo Ning Song Wen-biao Wu Bo Feng Jing-feng Fu Yu-tong Tu Min-min Liu Ran Xu Yu-bo Zhou Gang Wei Jia Li 
supported by National Natural Science Foundation of China(81821005);Guangdong High-level New R&D Institute(2019B090904008);Guangdong High-level Innovative Research Institute(2021B0909050003);Science and Technology Commission of Shanghai Municipality(18431907100 and 19430750100).
Current therapy for acute myeloid leukemia (AML) is largely hindered by the development of drug resistance of commonly used chemotherapy drugs, including cytarabine, daunorubicin, and idarubicin. In this study, we inv...
关键词:acute myeloid leukemia CYTARABINE DAUNORUBICIN IDARUBICIN drug resistant multi-omics AUTOPHAGY chloroquine phosphate 
Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes被引量:4
《Chinese Chemical Letters》2022年第10期4600-4604,共5页George Frimpong Boafo Yejiao Shi Qingqing Xiao Kosheli Thapar Magar Makhloufi Zoulikha Xuyang Xing Chao Teng Emmanuel Brobbey Xiaotong Li Xiaohong Jiang Xiaochun Wang Yi Yang Samuel Kesse Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823 and 82073782);the Double First-Class(No.CPU2018PZQ13)of the China Pharmaceutical University;the Shanghai Science and Technology Committee(No.19430741500);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine(No.zdsys-202103)。
Breast cancer is the most prevalent cancer in women,and it was hard to prevent or diagnose at an early stage.Thus,it is imperative to develop advanced therapeutics for effective treatment.Herein,a targeted daunorubici...
关键词:Breast cancer DAUNORUBICIN CYTARABINE CO-DELIVERY Liposomes 
Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DNA fragmentation被引量:1
《Cancer Drug Resistance》2019年第2期335-350,共16页Akimasa Seno Akifumi Mizutani Kazuki Aizawa Ryoma Onoue Junko Masuda Naotaka Ochi Saki Taniguchi Tatsuyuki Sota Yuki Hiramoto Taisuke Michiue Neha Nair Masaharu Seno 
Aim:To identify a drug that can effectively eliminate these cancer stem cells(CSCs)and determine its mode of action.Methods:CSCs were obtained from mouse induced pluripotent stem cells(miPSCs)using cancer cell-conditi...
关键词:DAUNORUBICIN cancer stem cell DNA fragmentation 
Different influence of Arac combined with idarubicin and with daunorubicin on malignant molecule expression of acute myelocytic leukemia
《Journal of Hainan Medical University》2018年第5期27-30,共4页Abudourexiti Nuerbiya Tuerhong Weinila Yimingniyazi Nueramina Palerdan Aisha 
Objective:To study the different influence of idarubicin + Arac (IA) therapy and daunorubicin + Arac (DA) therapy on malignant molecule expression of acute myelocytic leukemia. Methods: A total of 56 patients who were...
关键词:Acute myelocytic LEUKEMIA IDARUBICIN DAUNORUBICIN ARAC MALIGNANT MOLECULE 
Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy被引量:1
《Bioactive Materials》2017年第2期96-100,共5页He Lian Zhaoxu Meng 
This work is supported by the Scientific Research General Project of Liaoning Provincial Department of Education(No.L2014388);the Natural Science Foundation of Liaoning Province(No.2015020753);Nature Science Foundation of China(No.81503020,No.31600767).
Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect.The present study outlines the fabrication of daunorubicin hydrochloride-loaded poly (ε-caprolactone)(PCL) fibrous...
关键词:Melt electrospinning Drug delivery system Poly(ε-caprolactone) Daunorubicin hydrochloride Tumor therapy 
Augmented efficacy and the mechanism of a combined use of daunorubicin with rofecoxib in treatment of triple-negative breast cancer
《Journal of Chinese Pharmaceutical Sciences》2016年第6期438-447,共10页赵曜 张婧莹 胡英杰 吴佳栓 卜英子 吕万良 
National Natural Science Foundation of China(Grant No.81373343);the Key Grant of Beijing Natural Science Foundation(Grant No.7131009)
Triple-negative breast cancer is the tumor that lacks expressions of estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor-2(HER2). A regular chemotherapy cannot eradicate t...
关键词:DAUNORUBICIN ROFECOXIB Triple-negative breast cancer APOPTOSIS AUTOPHAGY 
Is Takotsubo syndrome in patients receiving chemotherapy drug-specific?
《World Journal of Clinical Cases》2015年第2期204-205,共2页John E Madias 
In commenting on a case report of a 55-year-old man who suffered Takotsubo syndrome(TTS), in the setting of receiving chemotherapy with cytarabine and daunorubicin for acute myeloid leukemia, the author expresses his ...
关键词:DAUNORUBICIN Radiotherapy CARDIOTOXICITY TAKOTSUBO syndrome Malignancies CHEMOTHERAPY CYTARABINE ANTHRACYCLINES Cardiomyopathy Autonomic sympathetic Nervous system 
Chemotherapy induced Takotsubo cardiomyopathy被引量:1
《World Journal of Clinical Cases》2014年第10期565-568,共4页Sunny Goel Abhishek Sharma Aakash Garg Abhinav Chandra Vijay Shetty 
Chemotherapy has been linked with Takotsubo cardiomyopathy. Most of the literature on chemotherapy associated Takotsubo cardiomyopathy is on the drug 5-fluorouracil. In this report, we describe the case of a 55-year-o...
关键词:TAKOTSUBO CARDIOMYOPATHY CHEMOTHERAPY CYTARABINE DAUNORUBICIN 
Daunorubicin导致急性心脏毒性的案例报告
《臺灣臨床藥學雜誌》林佩姿(Pei-Tzu Lin) 張展維(Chan-Wei Chang) 戴慶玲(Ching-Ling Tai) 
Daunorubicin为anthracycline类抗肿瘤药品,主要用於血液癌症的治疗。除恶心呕吐、骨髓抑制、掉发和口腔溃疡,一般常见化学治疗副作用外,还存在令人困扰的心脏毒性问题。Anthracycline类导致的心脏毒性,可以分为急性和慢性两种。急...
关键词:急性心臟毒性 急性心衰竭 
miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2被引量:18
《Acta Biochimica et Biophysica Sinica》2012年第3期269-277,共9页Hao Li Lulu Hui Wenlin Xu 
The aim of this study was to investigate whether miR-181a could modulate the sensitivity of the leukemia drug- resistant cell line K562/A02 to the chemotherapeutic agent daunorubicin (DNR), and explore the mechanism...
关键词:miR- 181 a apoptosis BCL-2 
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